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Eyun Song
Eyun Song
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Dong Eun Song
Dong Eun Song
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Jonghwa Ahn
Jonghwa Ahn
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Tae Yong Kim
Tae Yong Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Won Bae Kim
Won Bae Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Young Kee Shong
Young Kee Shong
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Min Ji Jeon
Min Ji Jeon
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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Won Gu Kim
Won Gu Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea
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thyroid carcinomas (PTCs) to develop a homogeneous cohort ( Cancer Genome Atlas Research Network 2014 ). Limited data exist regarding the mutational profile in advanced thyroid cancers, such as poorly differentiated thyroid carcinomas (PDTCs), anaplastic
David Viola
David Viola
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Laura Valerio
Laura Valerio
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Laura Agate
Laura Agate
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Valeria Bottici
Valeria Bottici
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Agnese Biagini
Agnese Biagini
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Virginia Cappagli
Virginia Cappagli
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Letizia Pieruzzi
Letizia Pieruzzi
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Carlotta Giani
Carlotta Giani
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Elena Sabini
Elena Sabini
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Paolo Passannati
Paolo Passannati
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Luciana Puleo
Luciana Puleo
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Benedetta Pontillo-Contillo
Benedetta Pontillo-Contillo
Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Valentina Battaglia
Valentina Battaglia
Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Salvatore Mazzeo
Salvatore Mazzeo
Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy
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. 2013 ). Until recently, no effective therapeutic options have been available for patients with any type of advanced thyroid cancer. In fact, EBRT has significant toxicity and mainly plays a palliative role, and classical cytotoxic chemotherapies have
Mabel Ryder
Mabel Ryder
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Ronald A Ghossein
Ronald A Ghossein
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Julio C M Ricarte-Filho
Julio C M Ricarte-Filho
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Jeffrey A Knauf
Jeffrey A Knauf
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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James A Fagin
James A Fagin
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
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density of TAMs ( n =3) and tumors with a high density of TAMs ( n =3). Discussion Our study demonstrates, for the first time, that an increased density of TAMs is associated with tumor progression in advanced thyroid cancers. There is a remarkably strong
Tara Williamson
Tara Williamson
Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA
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Thais Biude Mendes
Thais Biude Mendes
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Universidade Federal de São Paulo, São Paulo, Brazil
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Natalie Joe
Natalie Joe
Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA
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Janete M Cerutti
Janete M Cerutti
Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Universidade Federal de São Paulo, São Paulo, Brazil
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Gregory J Riggins
Gregory J Riggins
Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA
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, Yoo et al . 2019 ). Although BRAF and RAS were the predominant drivers in PDTC and ATC, TERT promoter mutations and TP53 were highly prevalence in advanced thyroid cancers harboring BRAF or RAS ( Landa et al . 2013 , Liu et al . 2013
Ana Albero
Ana Albero
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Juliana Ester Lopéz
Juliana Ester Lopéz
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Alberto Torres
Alberto Torres
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Luis de la Cruz
Luis de la Cruz
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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Tomas Martín
Tomas Martín
Department of Oncology, Andalusian Agency for Health Technology Assessment (AETSA), Department of Endocrinology and Nutrition, University Hospital ‘Virgen Macarena’, Seville, Spain
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. ( doi:10.1158/1078-0432.CCR-10-0994 ). Cohen EE Rosen LS Vokes EE Kies MS Forastiere AA Worden FP Kane MA Sherman E Kim S Bycott P 2008 Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer
Xianhui Ruan
Xianhui Ruan
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xianle Shi
Xianle Shi
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Qiman Dong
Qiman Dong
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Yang Yu
Yang Yu
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xiukun Hou
Xiukun Hou
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xinhao Song
Xinhao Song
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Xi Wei
Xi Wei
Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Lingyi Chen
Lingyi Chen
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China
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Ming Gao
Ming Gao
Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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.1089/thy.2012.0329 ) 23427907 10.1089/thy.2012.0329 Covell LL Ganti AK 2015 Treatment of advanced thyroid cancer: role of molecularly targeted therapies . Targeted Oncology 10 311 – 324 . ( https://doi.org/10.1007/s11523-014-0331-z ) 10.1007/s
Lucas Leite Cunha
Lucas Leite Cunha
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Federal University of São Paulo, São Paulo, Brazil
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Laura Sterian Ward
Laura Sterian Ward
Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (Unicamp), Campinas, Brazil
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M Song E Ryu YM Song DE Kim SY Kim TY Kim WB Shong YK Jeon MJ 2021 Immune profiling of advanced thyroid cancers using fluorescent multiplex immunohistochemistry . Thyroid 31 61 – 67 . ( https://doi.org/10.1089/thy.2020
Xuguang Zhu
Xuguang Zhu
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Dong Wook Kim
Dong Wook Kim
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Li Zhao
Li Zhao
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Mark C Willingham
Mark C Willingham
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Sheue-yann Cheng
Sheue-yann Cheng
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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PV/PV Pten +/− mice, SAHA is not only ineffective therapeutically but paradoxically promotes thyroid cancer progression. These observations are reminiscent of the outcome of the clinical trial of 19 patients with advanced thyroid cancer ( Woyach et
Soomin Ahn
Soomin Ahn
Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea
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Tae Hyuk Kim
Tae Hyuk Kim
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Sun Wook Kim
Sun Wook Kim
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Chang Seok Ki
Chang Seok Ki
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Hye Won Jang
Hye Won Jang
Department of Medical Education, Sungkyunkwan University School of Medicine, Seoul, Korea
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Jee Soo Kim
Jee Soo Kim
Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Jung Han Kim
Jung Han Kim
Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Jun-Ho Choe
Jun-Ho Choe
Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Jung Hee Shin
Jung Hee Shin
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Soo Yeon Hahn
Soo Yeon Hahn
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Young Lyun Oh
Young Lyun Oh
Department of Pathology and Translational genomics, Sungkyunkwan University School of Medicine, Seoul, Korea
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Jae Hoon Chung
Jae Hoon Chung
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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and found higher expression in a subset of advanced thyroid cancers such as anaplastic thyroid carcinoma and follicular thyroid carcinoma. Identification of PD-L1 expression may have direct therapeutic relevance to patients with refractory thyroid
Fabián Pitoia
Fabián Pitoia
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events (AE) were considered. The authors concluded that sorafenib showed only a modest effect in patients with advanced thyroid cancer. I wonder if 70% of PR plus SD would be considered as a modest response to treatment of patients with advanced
