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autophagy modulation Type of cancer Therapy Independent effect on autophagy? Combinatorial effect with autophagy-targeted drugs? Inhibition or enhancement of autophagy as target? Spontaneous pituitary adenomas Acrylonitrile ( Kamijo et al . 1986 ) Yes
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Autophagy modulation as a potential therapeutic target for diverse diseases . Nature Reviews Drug Discovery 11 709 – 730 . ( https://doi.org/10.1038/nrd3802 ) 22935804 10.1038/nrd3802 Seitz C Hugle M Cristofanon S Tchoghandjian A Fulda S 2013 The
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Cellular Biochemistry 111 1426 – 1436 . ( doi:10.1002/jcb.22869 ). White E DiPaola R 2009 The double-edged sword of autophagy modulation in cancer . Clinical Cancer Research 15 5308 – 5316 . ( doi:10.1158/1078-0432.CCR-07-5023 ). White E
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The double-edged sword of autophagy modulation in cancer . Clinical Cancer Research 15 5308 – 5316 . ( doi:10.1158/1078-0432.CCR-07-5023 ). Won KY Kim GY Lim SJ Kim YW 2012 Decreased Beclin-1 expression is correlated with the growth of the primary
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Autophagy modulation in cancer: current knowledge on action and therapy . Oxidative Medicine and Cellular Longevity 2018 8023821 . ( https://doi.org/10.1155/2018/8023821 ) 29643976 Markosyan N Chen EP Evans RA Ndong V Vonderheide RH Smyth EM 2013