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Mojun Zhu Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Karl R Sorenson Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Rebecca Liu Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

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Bonnie E Gould Rothberg Smilow Cancer Hospital, Yale-New Haven Health System, New Haven, Connecticut, USA

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Thorvardur R Halfdanarson Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA

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range from observation to aggressive chemotherapy. In recent years, several review articles that summarize data regarding potential prognostic biomarkers for PNETs have been published ( Pape et al. 2008 , Oberstein & Saif 2012 , Chan et al. 2017

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0075
Volume/Issue:
Volume 28: Issue 12
Restricted access
Erin Gibbons Department of Microbiology and Immunology University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

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Manisha Taya Division of Hematology and Oncology, UT Southwestern, Dallas, Texas, USA

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Huixing Wu Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, Ohio, USA

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Samia H Lopa Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA

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Joel Moss Pulmonary Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA

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Elizabeth P Henske Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Francis X McCormack Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, Ohio, USA

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Stephen R Hammes Department of Microbiology and Immunology University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

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with other pulmonary disorders, making lung biopsy sometimes necessary ( Ryu et al. 2006 ). Currently, vascular endothelial growth factor-D (VEGF-D) is the only serum biomarker for LAM, with about two-thirds of biopsy-proven LAM patients having

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0312
Volume/Issue:
Volume 31: Issue 6
Restricted access
Yong-Zi Chen Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China

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Youngchul Kim Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Hatem H Soliman Department of Women’s Oncology and Experimental Therapeutics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Department of Clinical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA

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GuoGuang Ying Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China

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Jae K Lee Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Department of Clinical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA

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al . 2011 ). While these studies have shown potential of genomic biomarkers for predicting outcomes of breast cancer patients treated with chemotherapy, their prediction capabilities were limited to each specific combination chemotherapy, which was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0495
Volume/Issue:
Volume 25: Issue 6
Open access
Ophélie Delcorte CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Julie Craps FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Siam Mahibullah CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Catherine Spourquet CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Ludovic D’Auria Neurochemistry group, Institute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium

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Patrick Van Der Smissen PICT Platform, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Chantal Dessy FATH & MORF Unit, IREC, Université Catholique de Louvain, Brussels, Belgium

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Etienne Marbaix CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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Michel Mourad Surgery and Abdominal Transplantation Division, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Christophe E Pierreux CELL Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

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reduce overtreatment, the discovery and the development of more accurate diagnostic tools are a necessity ( Oblak et al. 2021 ). Recently, liquid biopsy has emerged as a promising opportunity to develop non-invasive and sensitive biomarkers for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0343
Volume/Issue:
Volume 29: Issue 7
Restricted access
Benjamin C Thomas Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Jonathan D Kay Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK

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Suraj Menon Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK

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Sarah L Vowler Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK

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Sarah N Dawson Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Laura J Bucklow Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Hayley J Luxton Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK

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Thomas Johnston Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Charlie E Massie Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular and Computational Diagnostics Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Michelle Pugh Genomics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Anne Y Warren Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Peter Barker National Institute for Health Research Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Keith Burling National Institute for Health Research Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Andy G Lynch Computational Biology Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Anne George Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Johanna Burge Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Marie Corcoran Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Sara Stearn Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Alastair D Lamb Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Naomi L Sharma Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Greg L Shaw Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
University College Hospital at Westmoreland Street, London, UK

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David E Neal Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, UK

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Hayley C Whitaker Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK

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biomarkers primarily detect differences between benign prostates and those containing primary tumour. Despite the large number of published manuscripts describing biomarkers for detecting prostate cancer, the detection of androgen-regulated prostate

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0287
Volume/Issue:
Volume 23: Issue 10
Free access
Jian Chen Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China
University of Science and Technology of China, Hefei, China
Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Qingyuan Hu Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Hongwei Hou Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Shuo Wang University of Science and Technology of China, Hefei, China

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Yunfei Zhang Henan Cancer Hospital, Zhengzhou University, Zhengzhou, China

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Yanbo Luo Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Huan Chen Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Huimin Deng Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Hongfu Zhu Quality Safety and Framework Convention on Tobacco Control Research Team, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China

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Lirong Zhang School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China

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Hansong Liu Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China

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An Wang Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China

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Yong Liu Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China

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, and there was metabolic coupling between tumor and stromal cells. The actual understanding of the metabolic phenotype of thyroid cancer cells will provide new prognostic biomarkers and therapeutic targets for aggressive tumor behavior ( Wojakowska et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0344
Volume/Issue:
Volume 26: Issue 12
Restricted access
Bethany Smith Department of Medicine, Samuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Priyanka Agarwal Department of Medicine, Samuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Neil A Bhowmick Department of Medicine, Samuel Ochin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Greater Los Angeles Veterans Administration, Los Angeles, California, USA

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body fluids) is emerging as signaling molecules between cells and robust biomarkers of cancer progression and therapy response. Gene regulation by miRs and reciprocal regulation of miRs have now been studied for over 15 years and extensively reviewed

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0525
Volume/Issue:
Volume 24: Issue 5
Open access
Jill I Murray Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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Nathan R West Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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Leigh C Murphy Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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Peter H Watson Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Translational Gastroenterology Unit, Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, Department of Biochemistry and Microbiology, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, Canada V8R 6V5

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intratumoural inflammatory response that it directs, affect the level of ESR1 in breast cancer? Also, does chronic inflammation affect response to endocrine therapy? ESR1 is a predictive biomarker in breast cancer Advances in knowledge regarding breast cancer

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0096
Volume/Issue:
Volume 22: Issue 1
Free access
Tanya K Day
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Tina Bianco-Miotto Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia
Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia

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excellent therapeutic targets. Epigenetic modifications like DNA methylation are also stable and technically easy to assess making them ideal biomarkers for diagnosis and prognosis. It is well established from candidate gene studies that epigenetic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0204
Volume/Issue:
Volume 20: Issue 5
Free access
Myriem Boufraqech Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Lisa Zhang Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Meenu Jain Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Dhaval Patel Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Ryan Ellis Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Yin Xiong Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Mei He Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Naris Nilubol Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Maria J Merino Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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Electron Kebebew Endocrine Oncology Branch Laboratory of Pathology National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, Maryland 20892, USA

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could be a helpful adjunct biomarker to FNA cytology for predicting benign lesions. Figure 7 Expression levels of miR-145 in thyroid FNA biopsy samples. Normalized −ΔCt values for the training group (A upper panel) and validation group (A lower panel

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0077
Volume/Issue:
Volume 21: Issue 4
Free access