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Anja Rudolph Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Rebecca Hein Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Sara Lindström Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Lars Beckmann Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Sabine Behrens Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jianjun Liu Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hugues Aschard Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Manjeet K Bolla Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jean Wang Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Thérèse Truong Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Emilie Cordina-Duverger Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Florence Menegaux Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Thomas Brüning Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Volker Harth Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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The GENICA Network Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Gianluca Severi Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Laura Baglietto Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Melissa Southey Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Stephen J Chanock Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jolanta Lissowska Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jonine D Figueroa Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Mikael Eriksson Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Keith Humpreys Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hatef Darabi Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Janet E Olson Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Kristen N Stevens Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Celine M Vachon Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Julia A Knight Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Gord Glendon Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Anna Marie Mulligan Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Alan Ashworth Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Nicholas Orr Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Minouk Schoemaker Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Penny M Webb Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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kConFab Investigators Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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AOCS Management Group Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Pascal Guénel Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Hiltrud Brauch Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Graham Giles Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Montserrat García-Closas Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Kamila Czene Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Georgia Chenevix-Trench Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Fergus J Couch Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Irene L Andrulis Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Anthony Swerdlow Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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David J Hunter Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Dieter Flesch-Janys Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Douglas F Easton Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Per Hall Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Heli Nevanlinna Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Peter Kraft Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany
Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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Jenny Chang-Claude Division of Cancer Epidemiology, PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Foundation for Quality and Efficiency in Health Care (IQWIG), Human Genetics, Department of Public Health and Primary Care, INSERM (National Institute of Health and Medical Research), Unité Mixte de Recherche Scientifique (UMRS) 1018, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute for Occupational Medicine and Maritime Medicine, Department of Internal Medicine, Institute of Pathology, Molecular Genetics of Breast Cancer, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Cancer Epidemiology Centre, Centre for Molecular, Department of Pathology, Division of Cancer Epidemiology and Genetics, Department of Cancer Epidemiology and Prevention, Department of Medical Epidemiology and Biostatistics, Department of Health Sciences Research, Samuel Lunenfeld Research Institute, Division of Epidemiology, Ontario Cancer Genetics Network, Laboratory Medicine Program, Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Queensland Institute of Medical Research, Peter MacCallum Cancer Center, Sections of Epidemiology and Genetics, Department of Laboratory Medicine and Pathology, Ontario Cancer Genetics Network, Department of Molecular Genetics, Division of Genetics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, Department of Oncology, Department of Obstetrics and Gynecology, Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany

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on behalf of the Breast Cancer Association Consortium
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Introduction Menopausal hormone therapy (MHT) is prescribed to women in order to alleviate climacteric symptoms and it is still commonly used despite evidence of associations with increased risk of cardiovascular diseases and breast cancer (BC

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0349
Volume/Issue:
Volume 20: Issue 6
Free access
Anastasia Alataki Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital and The Institute of Cancer Research, London, UK
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK

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Mitch Dowsett Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital and The Institute of Cancer Research, London, UK
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK

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Introduction Breast cancer development and progression are significantly affected by signalling pathways involving oestrogen receptor (ER) and growth factor receptors ( Arpino et al. 2008 ). Over 80% of all breast cancer cases are deemed ER

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-21-0293
Volume/Issue:
Volume 29: Issue 8
Open access
John W Cassidy Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ankita S Batra Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Wendy Greenwood Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Alejandra Bruna Department of Oncology, University of Cambridge, Cambridge, UK

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Introduction Breast cancer (herein BC) is not a single disease, but is instead a collection of diseases that have distinct histopathological features and genetic and genomic variability linked to diverse prognostic outcomes. Recent research

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Review Article
DOI:
https://doi.org/10.1530/ERC-16-0251
Volume/Issue:
Volume 23: Issue 12
Open access
Andrew M K Law Tumour Development Group, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Elgene Lim Connie Johnson Breast Cancer Research Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia

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Christopher J Ormandy Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia

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David Gallego-Ortega Tumour Development Group, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia

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, Stein et al . 2004 , 2009 ). These same mechanisms might be hijacked by breast cancer cells to promote tumour tolerance and escape immune surveillance at the early stages of tumour formation, underscoring the importance of the innate immune system

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0404
Volume/Issue:
Volume 24: Issue 4
Open access
Liyan Zhou Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Guiying Bai Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yue Song Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaohui Liu Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaoqing Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yilin Deng Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yiran Si Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yehui Shi Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Hongli Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Introduction Breast cancer is the most prevalent malignant tumor in women worldwide, significantly affecting the quality of life and threatening the health of women ( Giaquinto et al. 2022 ). Multiple meta-analyses have shown that the risk

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0330
Volume/Issue:
Volume 31: Issue 9
Restricted access
Kara Britt Institute of Cancer Research,, The Garvan Institute of Medical Research,, The Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK
Institute of Cancer Research,, The Garvan Institute of Medical Research,, The Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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Alan Ashworth Institute of Cancer Research,, The Garvan Institute of Medical Research,, The Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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Matthew Smalley Institute of Cancer Research,, The Garvan Institute of Medical Research,, The Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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Introduction The only factor known to consistently decrease lifetime breast cancer risk regardless of ethnicity is early childbirth ( MacMahon et al . 1970 , Henderson et al . 1974 , Kelsey et al . 1993 ). Women who have undergone a first full

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0137
Volume/Issue:
Volume 14: Issue 4
Free access
Abigail Read The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
Division of Molecular Pathology, The Institute of Cancer Research, London, UK

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Rachael Natrajan The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
Division of Molecular Pathology, The Institute of Cancer Research, London, UK

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genes such as the RNA-binding protein RBM5 have been implicated in breast cancers as having an opposing role because the resulting isoform is more anti-apoptotic ( Fushimi et al . 2008 ). Another example is the B-cell lymphoma gene, Bcl-x , which can

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0068
Volume/Issue:
Volume 25: Issue 9
Open access
P This Service de Chirurgie à orientation Sénologique, Institut Curie, Paris, France. pthis@ch-versailles.fr

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A De La Rochefordière Service de Chirurgie à orientation Sénologique, Institut Curie, Paris, France. pthis@ch-versailles.fr

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K Clough Service de Chirurgie à orientation Sénologique, Institut Curie, Paris, France. pthis@ch-versailles.fr

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A Fourquet Service de Chirurgie à orientation Sénologique, Institut Curie, Paris, France. pthis@ch-versailles.fr

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H Magdelenat Service de Chirurgie à orientation Sénologique, Institut Curie, Paris, France. pthis@ch-versailles.fr

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Breast Cancer Group of the Institut Curie Service de Chirurgie à orientation Sénologique, Institut Curie, Paris, France. pthis@ch-versailles.fr

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The current extension of the indications for adjuvant chemotherapy, which predisposes to early menopause, and the media coverage of the benefits of hormone replacement therapy (HRT) have led patients with a history of breast cancer to seek treatments for estrogen deprivation. In breast cancer survivors, most physicians avoid HRT because of concern regarding the potential promotion of growth of occult malignant cells by estrogens, due to the estrogen dependence of breast cancer. Soy phytoestrogens are being promoted as the 'natural alternative' to HRT and have been available without restrictions for several years as nutritional supplements. In this paper, data on the complex mammary effects of phytoestrogens in epidemiological studies, in in vitro studies, as well as in in vivo studies on animal carcinogenesis are reviewed. The potential benefits and risks of phytoestrogens are analyzed, and the prescription of phytoestrogens to postmenopausal women after breast cancer and the coprescription with the anti-estrogen tamoxifen are discussed. The absence of controlled trials and technical checking of extraction and titration in these preparations on 'free sale' raise a new problem in terms of public health and justify close reasoning and a cautious attitude of physicians, as well as straight information given to women, especially after breast cancer.

Article Type:
Abstract
Volume/Issue:
Volume 8: Issue 2
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Marion T Weigel The Institute of Cancer Research, Royal Marsden Hospital, Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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Mitch Dowsett The Institute of Cancer Research, Royal Marsden Hospital, Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK
The Institute of Cancer Research, Royal Marsden Hospital, Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK

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Introduction Breast cancer is still one of the leading causes of cancer death in women, but there has been a sustained decline in mortality rates over the last decades. The incremental application of increasingly effective adjuvant medical

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0136
Volume/Issue:
Volume 17: Issue 4
Free access
Nicola Normanno
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Massimo Di Maio
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Ermelinda De Maio
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Antonella De Luca
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Andrea de Matteis
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Antonio Giordano
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Francesco Perrone
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Introduction It has long been established that estrogen is involved in the pathogenesis of breast carcinoma, and that it sustains the growth of breast cancer cells that express the receptor for this hormone. Indeed, approximately 70

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.00857
Volume/Issue:
Volume 12: Issue 4
Free access