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Kyungmin Lee
Kyungmin Lee
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Sang-Hyun Lee
Sang-Hyun Lee
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Wooil Kim
Wooil Kim
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science & Technology, Daejeon, Republic of Korea
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Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science & Technology, Daejeon, Republic of Korea
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Jangwook Lee
Jangwook Lee
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Jong-Gil Park
Jong-Gil Park
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Jang-Seong Kim
Jang-Seong Kim
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Jung Tae Kim
Jung Tae Kim
Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Yea Eun Kang
Yea Eun Kang
Department of Endocrinology and Metabolism, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Minho Shong
Minho Shong
Department of Internal Medicine, Chungnam National University, School of Medicine, Daejeon, Republic of Korea
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Hyo Jin Lee
Hyo Jin Lee
Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Jin-Man Kim
Jin-Man Kim
Department of Pathology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Won Gu Kim
Won Gu Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Bon Seok Koo
Bon Seok Koo
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
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Koon Soon Kim
Koon Soon Kim
Department of Endocrinology and Metabolism, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
Daejeon Endo Internal Medicine, Daejeon, Republic of Korea
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Daejeon Endo Internal Medicine, Daejeon, Republic of Korea
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Jeong-Ki Min
Jeong-Ki Min
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science & Technology, Daejeon, Republic of Korea
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Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science & Technology, Daejeon, Republic of Korea
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potential of tyrosine kinase inhibitors in the treatment of ATC with low Dsg2 expression levels by targeting hepatocyte growth factor receptor (HGFR, c-MET). Materials and methods Patients and tissue specimens We retrospectively selected 10 ATC
Gina Chia-Yi Chu
Gina Chia-Yi Chu
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Haiyen E Zhau
Haiyen E Zhau
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Ruoxiang Wang
Ruoxiang Wang
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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André Rogatko
André Rogatko
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Xu Feng
Xu Feng
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Majd Zayzafoon
Majd Zayzafoon
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Youhua Liu
Youhua Liu
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Mary C Farach-Carson
Mary C Farach-Carson
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Sungyong You
Sungyong You
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Jayoung Kim
Jayoung Kim
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Michael R Freeman
Michael R Freeman
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Leland W K Chung
Leland W K Chung
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
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bone and soft tissue homing ( Josson et al . 2011 ). These findings support an important role for RANKL–RANK signaling in PCa metastasis. Hepatocyte growth factor (HGF) and its receptor tyrosine kinase c-Met mediate cell motility, migration, increased
Stephen Hiscox
Stephen Hiscox
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Nicola J Jordan
Nicola J Jordan
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Wen Jiang
Wen Jiang
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Maureen Harper
Maureen Harper
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Richard McClelland
Richard McClelland
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Chris Smith
Chris Smith
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Robert I Nicholson
Robert I Nicholson
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/SF) is a multifunctional cytokine produced by stromal cells and exerts its effects in a paracrine fashion, through activation of the c-Met receptor protein, which is frequently expressed on the cells of epithelial origin ( Comoglio & Trusolino 2002
Ralph Blumhardt
Ralph Blumhardt
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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Ely A Wolin
Ely A Wolin
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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William T Phillips
William T Phillips
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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Umber A Salman
Umber A Salman
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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Ronald C Walker
Ronald C Walker
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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Brendan C Stack Jr
Brendan C Stack Jr
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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Darlene Metter
Darlene Metter
University of Texas Health Science Center at San Antonio, San Antonio Military Medical Center, Tennessee Valley VA Healthcare System, Vanderbilt University Medical Center, UAMS Thyroid Center, San Antonio, Texas, USA
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Differentiated thyroid cancer (DTC) is the most common endocrine malignancy and the fifth most common cancer in women. DTC therapy requires a multimodal approach, including surgery, which is beyond the scope of this paper. However, for over 50 years, the post-operative management of the DTC post-thyroidectomy patient has included radioactive iodine (RAI) ablation and/or therapy. Before 2000, a typical RAI post-operative dose recommendation was 100 mCi for remnant ablation, 150 mCi for locoregional nodal disease, and 175–200 mCi for distant metastases. Recent recommendations have been made to decrease the dose in order to limit the perceived adverse effects of RAI including salivary gland dysfunction and inducing secondary primary malignancies. A significant controversy has thus arisen regarding the use of RAI, particularly in the management of the low-risk DTC patient. This debate includes the definition of the low-risk patient, RAI dose selection, and whether or not RAI is needed in all patients. To allow the reader to form an opinion regarding post-operative RAI therapy in DTC, a literature review of the risks and benefits is presented.
Elke Tatjana Aristizabal Prada
Elke Tatjana Aristizabal Prada
Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
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Gerald Spöttl
Gerald Spöttl
Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
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Julian Maurer
Julian Maurer
Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
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Michael Lauseker
Michael Lauseker
Institute for Medical Information Sciences, Biometry, and Epidemiology, Campus Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany
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Eva Jolanthe Koziolek
Eva Jolanthe Koziolek
Department of Nuclear Medicine, University Medical Center Charité, Berlin, Germany
German Cancer Consortium (DKTK), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
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German Cancer Consortium (DKTK), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
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Jörg Schrader
Jörg Schrader
I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
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Ashley Grossman
Ashley Grossman
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Royal Free Hospital ENETS Centre of Excellence, London, UK
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Royal Free Hospital ENETS Centre of Excellence, London, UK
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Karel Pacak
Karel Pacak
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
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Felix Beuschlein
Felix Beuschlein
Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland
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Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland
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Christoph Joseph Auernhammer
Christoph Joseph Auernhammer
Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
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Svenja Nölting
Svenja Nölting
Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
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in both resistant cell lines, compared to the sensitive control cell line ( P < 0.01). Everolimus resistance increased migration potential and baseline c-Met activation The migration assay reflected a significant increase in the
Chiara Alessandra Cella
Chiara Alessandra Cella
Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy
Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy
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Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy
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Riccardo Cazzoli
Riccardo Cazzoli
Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy
Metal Targeted Therapy & Immunology lab, Childrens’ cancer institute, Sydney, NSW, Australia
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Metal Targeted Therapy & Immunology lab, Childrens’ cancer institute, Sydney, NSW, Australia
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Nicola Fazio
Nicola Fazio
Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy
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Giuseppina De Petro
Giuseppina De Petro
Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy
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Germano Gaudenzi
Germano Gaudenzi
Laboratory of Geriatric and Oncologic Neuroendocrinology Research, IRCCS, Istituto Auxologico Italiano, Milan, Italy
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Silvia Carra
Silvia Carra
Laboratory of Endocrine and Metabolic Research, IRCCS, Istituto Auxologico Italiano, Milan, Italy
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Mauro Romanenghi
Mauro Romanenghi
Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy
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Francesca Spada
Francesca Spada
Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy
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Ilaria Grossi
Ilaria Grossi
Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy
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Isabella Pallavicini
Isabella Pallavicini
Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy
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Saverio Minucci
Saverio Minucci
Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
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Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
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Giovanni Vitale
Giovanni Vitale
Laboratory of Geriatric and Oncologic Neuroendocrinology Research, IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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enhancing the hypoxia pathway and subsequently the mesenchymal–epithelial transition (MET) ( Rapisarda et al. 2009 , Villaume et al. 2010 ). The upregulation of mesenchymal–epithelial transition factor (c-MET), which is known to be involved in the
David J Gross
David J Gross
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Gabriel Munter
Gabriel Munter
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Menachem Bitan
Menachem Bitan
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Tali Siegal
Tali Siegal
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Alberto Gabizon
Alberto Gabizon
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Ronny Weitzen
Ronny Weitzen
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Ofer Merimsky
Ofer Merimsky
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Aliza Ackerstein
Aliza Ackerstein
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Asher Salmon
Asher Salmon
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Avishai Sella
Avishai Sella
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Shimon Slavin
Shimon Slavin
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( Adams et al. 2002 ). However, it has recently been shown that tumor oxygen deprivation can be a double-edged sword, since hypoxia induced signaling via the c -Met in tumor cells can result in a more aggressive tumor phenotype ( Bottaro & Liotta 2003
Christina M Knippler
Christina M Knippler
Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Wexner Medical Center and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
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Motoyasu Saji
Motoyasu Saji
Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Wexner Medical Center and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
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Neel Rajan
Neel Rajan
College of Arts and Sciences, The Ohio State University, Columbus, Ohio, USA
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Kyle Porter
Kyle Porter
Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA
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Krista M D La Perle
Krista M D La Perle
Department of Veterinary Biosciences, Comparative Pathology & Mouse Phenotyping Shared Resource, The Ohio State University, Columbus, Ohio, USA
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Matthew D Ringel
Matthew D Ringel
Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Wexner Medical Center and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
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al. 2013 ), upregulation of c-MET ( Byeon et al. 2016 , 2017 , Knauf et al. 2018 ) and acquired mutations in RAS genes ( Ofir Dovrat et al. 2018 ). Group I PAKs are a family of kinases that are activated by the small Rho GTPases, RAC1 and
Camilo Jimenez
Camilo Jimenez
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Sasan Fazeli
Sasan Fazeli
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Alejandro Román-Gonzalez
Alejandro Román-Gonzalez
Department of Endocrinology and Diabetes, Universidad de Antioquia, Medellin, Colombia
Department of Endocrinology, Hospital Universitario San Vicente Fundacion, Medellin, Colombia
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Department of Endocrinology, Hospital Universitario San Vicente Fundacion, Medellin, Colombia
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-2 VEGFR-3 PDGFR-β RET c-MET FGFR1 Axitinib 1.2 0.25 0.29 1.6 - - - Cabozantinib - 0.035 - - 4 1.3 - Lenvatinib 22 4 5.2 39 - - 46 Pazopanib 10 30 47 84
Jennifer A Woyach
Jennifer A Woyach
Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, The Ohio State University, A438 Starling-Loving Hall, 320 West 10th Avenue, Columbus, Ohio 43210, USA
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Manisha H Shah
Manisha H Shah
Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, The Ohio State University, A438 Starling-Loving Hall, 320 West 10th Avenue, Columbus, Ohio 43210, USA
Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, The Ohio State University, A438 Starling-Loving Hall, 320 West 10th Avenue, Columbus, Ohio 43210, USA
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Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, The Ohio State University, A438 Starling-Loving Hall, 320 West 10th Avenue, Columbus, Ohio 43210, USA
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tyrosine kinase that has gained interest in thyroid cancer in addition to other malignancies is c-Met, a proto-oncogene that is the high-affinity receptor for hepatocyte growth factor and is important for regulation of cell migration, proliferation
