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Sarah E McClelland

chromosome segregation errors ( Fig. 1A ) increase genetic heterogeneity between tumour cells at each cell cycle, allowing rapid evolution of tumour genomes and presenting a challenge to cancer patient treatment (see below). Chromosome segregation errors can

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Callum Livingstone

significant advances in recent years. The purpose of this review is to provide the reader with a perspective and update on IGF2, with respect to its role in cancer and clinical utility for its measurement. The IGFs are part of a complex system, the components

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David L Vesely

2003 , Cataliotti & Burnett 2005 ). When these four cardiac hormones synthesized by the ANP prohormone gene are given in concentrations higher than those synthesized by the heart, they have anticancer effects on human pancreatic cancers growing in

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Massimo Terzolo, Giuseppe Reimondo, Paola Berchialla, Emanuele Ferrante, Elena Malchiodi, Laura De Marinis, Rosario Pivonello, Silvia Grottoli, Marco Losa, Salvatore Cannavo, Diego Ferone, Marcella Montini, Marta Bondanelli, Ernesto De Menis, Chiara Martini, Efisio Puxeddu, Antonino Velardo, Alessandro Peri, Marco Faustini-Fustini, Patrizia Tita, Francesca Pigliaru, Giulia Peraga, Giorgio Borretta, Carla Scaroni, Nicoletta Bazzoni, Antonio Bianchi, Alessandro Berton, Andreea Liliana Serban, Roberto Baldelli, Letizia Maria Fatti, Annamaria Colao, Maura Arosio, and for the Italian Study Group of Acromegaly

Italian patients and found that vascular disease and cancer were the main causes of death. Mortality was higher in patients with persistently active disease, and IGF1 levels at diagnosis, GH at the last follow-up, cancer and pituitary radiotherapy were

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Isabel Mayayo-Peralta, Wilbert Zwart, and Stefan Prekovic

system, metabolism, and brain. In addition to that, GR activity or lack thereof has been linked to various aspects of cancer biology; however, its role in cancer seems to be complex and highly context-dependent, as GR has been proposed to be both a tumor

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Adam W Nelson, Wayne D Tilley, David E Neal, and Jason S Carroll

Introduction Prostate cancer is the commonest, non-cutaneous cancer in men, affecting 214 per 1000 European men. It is the second commonest cause of cancer death, accounting for 15% of all male cancers in developed countries ( Heidenreich et al

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Kathrin A Schmohl, Peter J Nelson, and Christine Spitzweg

al. 2018 ). Given that they influence such a broad range of processes, it is not surprising that growing clinical and experimental evidence suggests that they are also implicated in cancer development and progression, affecting cancer cell

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Antonio De la Vieja and Pilar Santisteban

thyroid dysfunction and thyroid cancer ( Pfinder et al . 2016 ). On the other hand, radioactive iodine (RAI) therapy with 131 I has been the cornerstone adjuvant therapy for the treatment of thyroid cancer for decades ( Seidlin et al . 1946 ), with

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Yuji Ikeda, Kazuma Kiyotani, Poh Yin Yew, Taigo Kato, Kenji Tamura, Kai Lee Yap, Sarah M Nielsen, Jessica L Mester, Charis Eng, Yusuke Nakamura, and Raymon H Grogan

Introduction A cancer of a different site and histologic type that develops in a person who already has a cancer diagnosis is considered a second primary cancer. Certain primary cancers are associated with a high risk of developing a second primary

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Veronica Kalhori, Melissa Magnusson, Muhammad Yasir Asghar, Ilari Pulli, and Kid Törnquist

substantial amount of evidence has implicated S1P in the progression of several types of cancers by enhancing many central events such as proliferation, angiogenesis, migration, and invasion ( Alvarez et al . 2007 , Strub et al . 2010 , Alshaker et al