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Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel
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Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel
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-wide analysis was designed to identify IGF1-dependent genes and signaling pathways associated with cancer protection in LS. Our results identified a number of genes that are either over- or under-represented in LS-derived lymphoblastoid cells. Gene differential
Instituto de Endocrinología IEMYR, Quito, Ecuador
Maastricht University, Maastricht, The Netherlands
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SOD2. These findings are objective molecular events that support the notion that diminished GHR action underlies cancer protection in subjects belonging to the ELS cohort ( Guevara-Aguirre et al. 2011 ). Additionally, besides low serum IGF-I levels
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cancer protection. Classification of congenital IGF-1 deficiencies Prenatal IGF-1 expression is GH-independent though it becomes dependent on GH secretion shortly before birth ( Klammt et al . 2008 ). Hepatic IGF-1 biosynthesis remains dependent
Institute of Cancer Research,, The Garvan Institute of Medical Research,, The Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London SW3 6JB, UK
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+/PR+) breast cancer not ER negative/PR negative (ER−/PR−) breast cancer. Retrospective epidemiological studies have defined the contributions of parity, age at FFTB, and breastfeeding in breast cancer protection ( MacMahon et al . 1970 , Ursin et al . 2004
Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile
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Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA
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. Contradictions of GH–IGF-1 axis and cellular protection to DNA damage All the previously mentioned studies are apparently opposed to the studies of Chesnokova et al. ( Chesnokova et al. 2013 , 2016 , 2019 ) and to the cancer protection observed in LS
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. 2020 ). These findings may represent the molecular signature for cancer protection in LS. In summary, there is strong evidence linking the downregulation of GH/IGF-1 signaling to reduced cancer mortality. Similarly, overstimulation of GH and IGF-1
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
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Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand
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Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
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in the absence of growth hormone are more sensitive to doxorubicin than wild-type tumors . Endocrinology 162 . ( https://doi.org/10.1210/endocr/bqab013 ) Laron Z Kauli R Lapkina L & Werner H 2017 IGF-I deficiency, longevity and cancer
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that reduce breast cancer risk by having the opposite effects on the expression of these two genes. References Adlercreutz H 1995 Phytoestrogens: epidemiology and a possible role in cancer protection. Environmental Health
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fatty acids in mammary and prostate cancer protection: a review . International Journal of Food Sciences and Nutrition 63 66 – 78 . doi:10.3109/09637486.2011.598849 . Ho SM Lee MT Lam HM Leung YK 2011 Estrogens and prostate cancer
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downregulation of the luminal, HS-MEC-secreted factors WNT4 and AREG ( Meier-Abt et al . 2013 ). The relevance of HS-MECs in parity-induced breast cancer protection was validated in human breast tissue assessed for the greatest transcriptional and methylation
