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Andrew McDonald Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Vaidehi Avadhani Grady Memorial Hospital, Atlanta, Georgia, USA

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Gabriela Oprea-Ilies Grady Memorial Hospital, Atlanta, Georgia, USA

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Katerina Zakka Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Gregory B Lesinski Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Olumide B Gbolahan Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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Olatunji Alese Winship Cancer Institute at Emory University, Atlanta, Georgia, USA

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as neuroendocrine carcinoma (NEC). There is an inverse correlation between overall survival (OS) and tumor grade, with HG NEC having the worst prognosis among GEP-NEN subtypes ( Klimstra et al. 2019 ). GEP-NECs have an aggressive natural history

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0046
Volume/Issue:
Volume 31: Issue 10
Restricted access
Paul C Marker School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Christopher J Unterberger School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Steven M Swanson School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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and rats where changes in the activity of GH and/or mediators of GH action have altered the initiation and/or progression of experimentally induced carcinomas. Early evidence that GH could promote carcinogenesis came from chronic injection of rats with

Article Type:
Review Article
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Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0403
Volume/Issue:
Volume 30: Issue 5
Free access
T M A Kerkhofs Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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M H T Ettaieb Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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I G C Hermsen Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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H R Haak Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands
Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands
Department of Internal Medicine, Division of General Internal Medicine, Department of Health Services Research and CAPHRI School for Public Health and Primary Care, Maxima Medical Center, Ds. Th. Fliednerstraat 1, 5631 BM Eindhoven/Veldhoven, The Netherlands

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with suspect adrenocortical carcinoma. Clinical prognostic factors Currently, the most important prognostic factor in ACC is the stage of disease at presentation ( Fassnacht et al . 2009 ). The European Network for the Study of Adrenal Tumours (ENSAT

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0318
Volume/Issue:
Volume 22: Issue 6
Free access
Jae Hyun Park Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea

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Jong Ho Yoon Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea

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Introduction Surgical treatment for a differentiated thyroid carcinoma (DTC) derived from follicular cells is a starting point of a multifaceted treatment approach. Even though DTC is generally non-aggressive and has good prognosis, choosing

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0085
Volume/Issue:
Volume 26: Issue 7
Free access
Filipa Morais-Santos School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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Vera Miranda-Gonçalves School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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Sílvia Pinheiro School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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André F Vieira School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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Joana Paredes School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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Fernando C Schmitt School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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Fátima Baltazar School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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Céline Pinheiro School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal
School of Health Sciences, ICVS/3B's – PT Government Associate Laboratory, IPATIMUP – Institute of Molecular Pathology and Immunology, Medical Faculty, Department of Laboratory Medicine and Pathobiology, Department of Pathology, Barretos School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

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, 2010 , de Oliveira et al . 2012 ), reinforcing the potential of MCT1 as a cancer therapeutic target. Recently, our group described an increase in MCT1 expression in breast carcinomas, when compared with normal tissue. This enhanced MCT1 expression, as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0132
Volume/Issue:
Volume 21: Issue 1
Free access
Giada Poli Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Daniele Guasti Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Elena Rapizzi Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Rossella Fucci Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Letizia Canu Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Alessandra Bandinelli Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Nicoletta Cini Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Daniele Bani Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Massimo Mannelli Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences
Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Michaela Luconi Endocrinology Unit, Research Unit of Histology and Embryology, Laboratorio Generale, Istituto Toscano Tumori, Department of Experimental and Clinical Biomedical Sciences

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Introduction Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine tumor with an incidence of 0.5–2 cases per million people every year. ACC prognosis is mainly dependent on the stage at diagnosis ( Fassnacht et al . 2009 ), with the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0150
Volume/Issue:
Volume 20: Issue 4
Free access
Xi Zhang Shenzhen Bay Laboratory, Shenzhen, P R China

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Vijay Pandey Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Vipul Bhardwaj Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Tao Zhu Shenzhen Bay Laboratory, Shenzhen, P R China
Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P R China
The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P R China

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Peter E Lobie Shenzhen Bay Laboratory, Shenzhen, P R China
Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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precluded definitive demonstration that hGH was actually synthesized and secreted in extrapituitary cancer. As an endocrine hormone, immunohistochemical detection of hGH in carcinoma cells in histopathological sections could be, and initially was

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-23-0120
Volume/Issue:
Volume 31: Issue 1
Restricted access
Johan O Paulsson Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Na Wang Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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Jiwei Gao Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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Adam Stenman Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Ninni Mu Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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Weng-Onn Lui Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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Catharina Larsson Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden

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the last few decades, especially since the beginning of the 1990s, but the mortality rate has remained relatively stable ( Kitahara & Sosa 2016 ). The increase is mainly attributable to the increasing incidence of papillary thyroid carcinoma (PTC), but

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0446
Volume/Issue:
Volume 27: Issue 5
Open access
S G Creemers Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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P M van Koetsveld Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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W W De Herder Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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F Dogan Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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G J H Franssen Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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R A Feelders Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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L J Hofland Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Introduction Adrenocortical carcinoma (ACC) is a highly malignant disease with limited treatment options ( Creemers et al. 2016 a ). The only curative treatment is tumor-directed surgery (R0 resection) in case of local disease. The high

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0500
Volume/Issue:
Volume 26: Issue 3
Free access
Yoshiaki Onodera Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Hozumi Motohashi Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Kiyoshi Takagi Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Yasuhiro Miki Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Yukiko Shibahara Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Mika Watanabe Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Takanori Ishida Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Hisashi Hirakawa Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Hironobu Sasano Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Masayuki Yamamoto Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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Takashi Suzuki Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

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markedly influenced predominantly by the proliferative activity of the carcinoma cells ( van Diest et al . 2004 ). Nevertheless, breast cancer patients frequently received adjuvant therapy such as endocrine therapy (tamoxifen, luteinizing hormone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0234
Volume/Issue:
Volume 21: Issue 2
Free access