Search Results

You are looking at 1 - 10 of 450 items for :

  • "cell signaling" x
Clear All
Free access

Sara Redaelli, Ivan Plaza-Menacho and Luca Mologni

decades on the genetics and cell signaling of the RET proto-oncogene has described two main mechanisms of action for specific disease-phenotype-associated RET mutations. First, mutations affecting the extracellular cysteine-rich domain (CRD) of RET

Free access

Huy Q Ta and Daniel Gioeli

It is increasingly clear that castration-resistant prostate cancer (PCa) is dependent on the androgen receptor (AR). This has led to the use of anti-androgen therapies that reduce endogenous steroid hormone production as well as the use of AR antagonists. However, the AR does not act in isolation and integrates with a milieu of cell-signaling proteins to affect cell biology. It is well established that cancer is a genetic disease resulting from the accumulation of mutations and chromosomal translocations that enables cancer cells to survive, proliferate, and disseminate. To maintain genomic integrity, there exists conserved checkpoint signaling pathways to facilitate cell cycle delay, DNA repair, and/or apoptosis in response to DNA damage. The AR interacts with, affects, and is affected by these DNA damage-response proteins. This review will focus on the connections between checkpoint signaling and the AR in PCa. We will describe what is known about how components of checkpoint signaling regulate AR activity and what questions still face the field.

Open access

Hyun Ho Han, Baek Gil Kim, Joo Hyun Lee, Suki Kang, Ji Eun Kim and Nam Hoon Cho

phosphorylated ERK1/2 (Cell Signaling Technology) at the manufacturer’s recommended concentrations, and incubated for 1 h. For isotype control, fluorochrome-conjugated rabbit IgG was used at the same concentration. Cells were washed, resuspended in PBS, sorted

Free access

Michael Derwahl and Diana Nicula

Prossnitz ER 2005 A transmembrane intracellular estrogen receptor mediates rapid cell signaling . Science 307 1625 – 1630 . ( doi:10.1126/science.1106943 ). Rezza A Sennett R Rendl M 2014 Adult stem cell niches: cellular and molecular

Free access

Athanasios Bikas, Kirk Jensen, Aneeta Patel, John Costello Jr, Dennis McDaniel, Joanna Klubo-Gwiezdzinska, Olexander Larin, Victoria Hoperia, Kenneth D Burman, Lisa Boyle, Leonard Wartofsky and Vasyl Vasko

-AMPK (Thr172), total AMPK, phospho-AKT (Ser473), poly (ADP-ribose) polymerase (PARP), cleaved-caspase 3, LC3B, p62, BIP, PKM2 (Cell Signaling, Boston, MA, USA), cyclin D1, perforin, and b-actin (Santa Cruz Biotechnologies). Membranes were then incubated with

Free access

Yulia Koryakina, Huy Q Ta and Daniel Gioeli

interesting and exciting hypotheses about the role of AR phosphorylation in prostate cancer progression, both mechanistically and prognostically. Summary The AR integrates input from hormone binding with the cell signaling network through post

Free access

Girish V Shah, Shibu Thomas, Anbalagan Muralidharan, Yong Liu, Paul L Hermonat, Jill Williams and Jaideep Chaudhary

generated. The first four networks (networks 1–4) with scores of 39, 25, 25, and 20 indicated that genes within these pathways regulated cell–cell signaling, cell cycle, DNA replication and tumor biology respectively. High scores of these networks suggest

Free access

Zijie Feng, Jian Ma and Xianxin Hua

processes and various biological activities such as transcriptional regulation and cell signaling ( Orford et al. 1997 , Waby et al. 2008 ). Currently, multiple PTMs have been found for various proteins, including phosphorylation, methylation

Free access

Aleksandra M Ochnik and Robert C Baxter

downstream cell signaling of effector molecules that regulate PI3K/AKT, FAK and MAPK/MEK intracellular signaling pathways. SphK1 is phosphorylated and activated by ERK leading to both intracellular and extracellular activity of the bioactive lipid molecular

Free access

Fazlul H Sarkar, Yiwei Li, Zhiwei Wang and Dejuan Kong

. In this review, we summarize the current knowledge regarding the alterations in cell signaling pathways during the development and progression of PCa, and outline the evidence supporting the development of innovative strategies for targeting selective