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Natalie Sampson Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Hannes Neuwirt Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Martin Puhr Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Helmut Klocker Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Iris E Eder Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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focused on better understanding of androgen receptor (AR) signaling with our current knowledge being largely derived from experimental cell culture and animal models. In vitro cell cultures have the advantage of being relatively cheap and typically have

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-12-0401
Volume/Issue:
Volume 20: Issue 2
Free access
Jue Shi Department of Physics and Department of Biology, Center for Quantitative Systems Biology, Hong Kong Baptist University, Hong Kong, China

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Timothy J Mitchison Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

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-microtubule drugs and the spindle-targeting inhibitors. By further comparing the cell culture results with those from mouse tumor models, we would discuss potential therapeutic and toxic mechanisms of anti-mitotic drugs seen in the clinic. In our discussion of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0003
Volume/Issue:
Volume 24: Issue 9
Free access
James F Powers Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Brent Cochran Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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James D Baleja Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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Hadley D Sikes Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Xue Zhang Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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Inna Lomakin Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Troy Langford Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Kassi Taylor Stein Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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models. This paper describes a unique PDX and cell culture model for basic and pre-clinical studies of SDH-deficient GIST. The model, which we have named ‘the Ian GIST model’, is derived from an aggressive gastric GIST that arose in a young man with a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0115
Volume/Issue:
Volume 25: Issue 11
Free access
G Galli
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R Zonefrati
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A Gozzini
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C Mavilia
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V Martineti
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I Tognarini
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G Nesi
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T Marcucci
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F Tonelli
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M Tommasi
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C Casini Raggi
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P Pinzani
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M L Brandi
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the functional and growth properties of long-term cell cultures of an SST-secreting cancer (SS-C cells) obtained from a primary human somatostatinoma. We also evaluated the response of SS-C cells to various physiological and pharmacological agents

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00988
Volume/Issue:
Volume 13: Issue 1
Free access
Aura D Herrera-Martínez Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain

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Rosanna van den Dungen Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Fadime Dogan-Oruc Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Peter M van Koetsveld Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Michael D Culler Ipsen Bioscience, Cambridge, Massachusetts, USA

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Wouter W de Herder Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Raúl M Luque Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Richard A Feelders Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Leo J Hofland Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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). Most cell-based assays use traditional 2D monolayer cell cultures on flat, rigid substrates. 2D monolayer cultures have some limitations, and it has been recognized that the effectiveness of drugs in 2D monolayer in vitro culture systems are often not

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0086
Volume/Issue:
Volume 26: Issue 6
Free access
Ahmad M Alamri Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia

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Keunsoo Kang Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bethesda, Maryland, USA
Department of Microbiology, Dankook University, Cheonan, Republic of Korea

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Svenja Groeneveld Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
Department Pharmazie, Ludwig-Maximilians-Universität München, Munich, Germany

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Weisheng Wang Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

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Xiaogang Zhong Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, District of Columbia, USA

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Bhaskar Kallakury Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

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Lothar Hennighausen Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bethesda, Maryland, USA

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Xuefeng Liu Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

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Priscilla A Furth Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
Department of Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

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transcriptional consequences and cancer progenitor cell retention of two different primary cancer epithelial cell culture methodologies: the mammary epithelial cell-optimized EpiCult (B) system (Stemcell Technologies, Vancouver, BC, Canada) ( Yamaji et al. 2009

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0071
Volume/Issue:
Volume 23: Issue 7
Free access
D M Peehl Department of Urology, Stanford University School of Medicine, Stanford, California, USA

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far the most commonly used cell culture models of prostate cancer ( Bosland et al. 1996 ). Although other prostate cancer cell lines are available, recent studies revealed that many of these are in fact derivatives of the three aforementioned cell

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.00795
Volume/Issue:
Volume 12: Issue 1
Free access
James F Powers Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Brent Cochran Department of Developmental, Molecular and Chemical Biology

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James D Baleja Department of Developmental, Molecular and Chemical Biology

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Hadley D Sikes Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Andrew D Pattison Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia

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Xue Zhang Department of Developmental, Molecular and Chemical Biology

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Inna Lomakin Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Annette Shepard-Barry Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver Division National Institute of Child Health and Human Development, Bethesda, Maryland, USA

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Sun Jin Moon Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Troy F Langford Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Kassi Taylor Stein Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Richard W Tothill Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Yingbin Ouyang Cyagen US Inc, Santa Clara, California, USA

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Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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develop PCCs, we hypothesized that rats would a priori be superior to mice as a potential Sdhb tumor model. This communication describes the successful development of a new rat-derived xenograft and cell culture model that closely mirrors the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0474
Volume/Issue:
Volume 27: Issue 6
Open access
C Schaaf
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B Shan
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M Buchfelder Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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M Losa Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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J Kreutzer Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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W Rachinger Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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G K Stalla
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T Schilling Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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E Arzt Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany
Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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M J Perone Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany
Neuroendocrinology Group, Neurosurgical Clinic, Department of Neurosurgery, Neurosurgical Clinic, Neurosurgical Clinic, Department of Internal Medicine 1 and Clinical Chemistry, Laboratorio de Fisiología y Biología Molecular, IFIBYNE-CONICET, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany

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U Renner
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time about the role of curcumin in vivo in experimentally induced pituitary tumours of nude mice and in primary cell cultures of human pituitary adenomas. Materials and methods Materials Cell culture materials and reagents were obtained from Life

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0129
Volume/Issue:
Volume 16: Issue 4
Free access
Aleksander Skardal Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA
The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA

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Hemamylammal Sivakumar Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA

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Marco A Rodriguez Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA

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Liudmila V Popova Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Priya H Dedhia The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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platforms using human cells for mechanistic research can complement traditional animal models and 2D cell cultures. The creation of accurate 3D models that mimic human cell–cell, cell–extracellular matrix (ECM), and mechanical interactions of in vivo

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0344
Volume/Issue:
Volume 31: Issue 4
Restricted access