Search Results

You are looking at 1 - 10 of 22 items for :

  • "clinical biomarkers" x
  • Refine by access: All content x
Clear All
James Yao University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by James Yao in
Google Scholar
PubMed
Close
,
Abhishek Garg Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA

Search for other papers by Abhishek Garg in
Google Scholar
PubMed
Close
,
David Chen Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

Search for other papers by David Chen in
Google Scholar
PubMed
Close
,
Jaume Capdevila Vall d’Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Autonomous University of Barcelona, Barcelona, Spain

Search for other papers by Jaume Capdevila in
Google Scholar
PubMed
Close
,
Paul Engstrom Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

Search for other papers by Paul Engstrom in
Google Scholar
PubMed
Close
,
Rodney Pommier Oregon Health and Science University, Portland, Oregon, USA

Search for other papers by Rodney Pommier in
Google Scholar
PubMed
Close
,
Eric Van Cutsem University Hospitals Gasthuisberg/Leuven and KU Leuven, Leuven, Belgium

Search for other papers by Eric Van Cutsem in
Google Scholar
PubMed
Close
,
Simron Singh Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada

Search for other papers by Simron Singh in
Google Scholar
PubMed
Close
,
Nicola Fazio European Institute of Oncology, Milan, Italy

Search for other papers by Nicola Fazio in
Google Scholar
PubMed
Close
,
Wei He Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

Search for other papers by Wei He in
Google Scholar
PubMed
Close
,
Markus Riester Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA

Search for other papers by Markus Riester in
Google Scholar
PubMed
Close
,
Parul Patel Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

Search for other papers by Parul Patel in
Google Scholar
PubMed
Close
,
Maurizio Voi Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

Search for other papers by Maurizio Voi in
Google Scholar
PubMed
Close
,
Michael Morrissey Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA

Search for other papers by Michael Morrissey in
Google Scholar
PubMed
Close
,
Marianne Pavel University of Erlangen-Nuremberg, Erlangen, Germany

Search for other papers by Marianne Pavel in
Google Scholar
PubMed
Close
, and
Matthew Helmut Kulke Dana Farber Cancer Institute, Boston, Massachusetts, USA

Search for other papers by Matthew Helmut Kulke in
Google Scholar
PubMed
Close

Neuroendocrine tumors (NETs) have historically been subcategorized according to histologic features and the site of anatomic origin. Here, we characterize the genomic alterations in patients enrolled in three phase 3 clinical trials of NET of different anatomic origins and assess the potential correlation with clinical outcomes. Whole-exome and targeted panel sequencing was used to characterize 225 NET samples collected in the RADIANT series of clinical trials. Genomic profiling of NET was analyzed along with nongenomic biomarker data on the tumor grade and circulating chromogranin A (CgA) and neuron-specific enolase (NSE) levels from these patients enrolled in clinical trials. Our results highlight recurrent large-scale chromosomal alterations as a common theme among NET. Although the specific pattern of chromosomal alterations differed between tumor subtypes, the evidence for generalized chromosomal instability (CIN) was observed across all primary sites of NET. In pancreatic NET, although the P value was not significant, higher CIN suggests a trend toward longer survival (HR, 0.55, P = 0.077), whereas in the gastrointestinal NET, lower CIN was associated with longer survival (HR, 0.44, P = 0.0006). Our multivariate analyses demonstrated that when combined with other clinical data among patients with progressive advanced NETs, chromosomal level alteration adds important prognostic information. Large-scale CIN is a common feature of NET, and specific patterns of chromosomal gain and loss appeared to have independent prognostic value in NET subtypes. However, whether CIN in general has clinical significance in NET requires validation in larger patient cohort and warrants further mechanistic studies.

Open access
Nathan R West Deeley Research Centre, Department of Biochemistry and Microbiology, Department of Biochemistry and Medical Genetics, Department of Pathology and Laboratory Medicine, BC Cancer Agency, 2410 Lee Avenue, 3rd Floor Research, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Department of Biochemistry and Microbiology, Department of Biochemistry and Medical Genetics, Department of Pathology and Laboratory Medicine, BC Cancer Agency, 2410 Lee Avenue, 3rd Floor Research, Victoria, British Columbia, Canada V8R 6V5

Search for other papers by Nathan R West in
Google Scholar
PubMed
Close
,
Leigh C Murphy Deeley Research Centre, Department of Biochemistry and Microbiology, Department of Biochemistry and Medical Genetics, Department of Pathology and Laboratory Medicine, BC Cancer Agency, 2410 Lee Avenue, 3rd Floor Research, Victoria, British Columbia, Canada V8R 6V5

Search for other papers by Leigh C Murphy in
Google Scholar
PubMed
Close
, and
Peter H Watson Deeley Research Centre, Department of Biochemistry and Microbiology, Department of Biochemistry and Medical Genetics, Department of Pathology and Laboratory Medicine, BC Cancer Agency, 2410 Lee Avenue, 3rd Floor Research, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Department of Biochemistry and Microbiology, Department of Biochemistry and Medical Genetics, Department of Pathology and Laboratory Medicine, BC Cancer Agency, 2410 Lee Avenue, 3rd Floor Research, Victoria, British Columbia, Canada V8R 6V5
Deeley Research Centre, Department of Biochemistry and Microbiology, Department of Biochemistry and Medical Genetics, Department of Pathology and Laboratory Medicine, BC Cancer Agency, 2410 Lee Avenue, 3rd Floor Research, Victoria, British Columbia, Canada V8R 6V5

Search for other papers by Peter H Watson in
Google Scholar
PubMed
Close

The most important clinical biomarker for breast cancer management is oestrogen receptor alpha (ERα). Tumours that express ER are candidates for endocrine therapy and are biologically less aggressive, while ER-negative tumours are largely treated with conventional chemotherapy and have a poor prognosis. Despite its significance, the mechanisms regulating ER expression are poorly understood. We hypothesised that the inflammatory cytokine oncostatin M (OSM) can downregulate ER expression in breast cancer. Recombinant OSM potently suppressed ER protein and mRNA expression in vitro in a dose- and time-dependent manner in two human ER+ breast cancer cell lines, MCF7 and T47D. This was dependent on the expression of OSM receptor beta (OSMRβ) and could be blocked by inhibition of the MEKK1/2 mitogen-activated protein kinases. ER loss was also necessary for maximal OSM-induced signal transduction and migratory activity. In vivo, high expression of OSM and OSMR mRNA (determined by RT-PCR) was associated with reduced ER (P<0.01) and progesterone receptor (P<0.05) protein levels in a cohort of 70 invasive breast cancers. High OSM and OSMR mRNA expression was also associated with low expression of ESR1 (ER, P<0.0001) and ER-regulated genes in a previously published breast cancer gene expression dataset (n=321 cases). In the latter cohort, high OSMR expression was associated with shorter recurrence-free and overall survival in univariate (P<0.0001) and multivariate (P=0.022) analyses. OSM signalling may be a novel factor causing suppression of ER and disease progression in breast cancer.

Free access
Josefine Bostner Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Josefine Bostner in
Google Scholar
PubMed
Close
,
Elin Karlsson Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Elin Karlsson in
Google Scholar
PubMed
Close
,
Cecilia Bivik Eding Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Cecilia Bivik Eding in
Google Scholar
PubMed
Close
,
Gizeh Perez-Tenorio Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Gizeh Perez-Tenorio in
Google Scholar
PubMed
Close
,
Hanna Franzén Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Hanna Franzén in
Google Scholar
PubMed
Close
,
Aelita Konstantinell Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Aelita Konstantinell in
Google Scholar
PubMed
Close
,
Tommy Fornander Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Tommy Fornander in
Google Scholar
PubMed
Close
,
Bo Nordenskjöld Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Bo Nordenskjöld in
Google Scholar
PubMed
Close
, and
Olle Stål Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Medicine, Department of Oncology, Department of Oncology

Search for other papers by Olle Stål in
Google Scholar
PubMed
Close

expression and RPS6KB1 gene amplification and expression ( van der Hage et al . 2004 , Perez-Tenorio et al . 2011 ). The S6K1 antibody demonstrated high specificity and could serve as a clinical biomarker. Overactivated S6K has been suggested an upcoming

Open access
Kjell Oberg Department of Endocrine Oncology, University Hospital, Entrance 78, SE-751 85 Uppsala, Sweden

Search for other papers by Kjell Oberg in
Google Scholar
PubMed
Close

applied in most NETs but should be complemented with specific markers related to localisation of the primary tumour as well as clinical symptoms. Although CgA serve as a good clinical biomarker, we are in deep need of new biomarkers for detection of early

Free access
T L Veveris-Lowe
Search for other papers by T L Veveris-Lowe in
Google Scholar
PubMed
Close
,
M G Lawrence
Search for other papers by M G Lawrence in
Google Scholar
PubMed
Close
,
R L Collard
Search for other papers by R L Collard in
Google Scholar
PubMed
Close
,
L Bui
Search for other papers by L Bui in
Google Scholar
PubMed
Close
,
A C Herington
Search for other papers by A C Herington in
Google Scholar
PubMed
Close
,
D L Nicol
Search for other papers by D L Nicol in
Google Scholar
PubMed
Close
, and
J A Clements
Search for other papers by J A Clements in
Google Scholar
PubMed
Close

, Willemsen NM, Myers SA & Dong Y 2004 The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers. Critical Reviews in Clinical Laboratory Sciences 41 265 –312

Free access
Bo Chen Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Bo Chen in
Google Scholar
PubMed
Close
,
Guochun Zhang Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Guochun Zhang in
Google Scholar
PubMed
Close
,
Guangnan Wei Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Guangnan Wei in
Google Scholar
PubMed
Close
,
Yulei Wang Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
School of Medicine, South China University of Technology, Guangzhou, Guangdong, China

Search for other papers by Yulei Wang in
Google Scholar
PubMed
Close
,
Liping Guo Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China

Search for other papers by Liping Guo in
Google Scholar
PubMed
Close
,
Jiali Lin Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China

Search for other papers by Jiali Lin in
Google Scholar
PubMed
Close
,
Kai Li Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Kai Li in
Google Scholar
PubMed
Close
,
Hsiaopei Mok Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Hsiaopei Mok in
Google Scholar
PubMed
Close
,
Li Cao Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Li Cao in
Google Scholar
PubMed
Close
,
Chongyang Ren Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Chongyang Ren in
Google Scholar
PubMed
Close
,
Lingzhu Wen Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Lingzhu Wen in
Google Scholar
PubMed
Close
,
Minghan Jia Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Minghan Jia in
Google Scholar
PubMed
Close
,
Cheukfai Li Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Cheukfai Li in
Google Scholar
PubMed
Close
,
Ting Hou Burning Rock Biotech, Guangzhou, Guangdong, China

Search for other papers by Ting Hou in
Google Scholar
PubMed
Close
,
Han Han-Zhang Burning Rock Biotech, Guangzhou, Guangdong, China

Search for other papers by Han Han-Zhang in
Google Scholar
PubMed
Close
,
Jing Liu Burning Rock Biotech, Guangzhou, Guangdong, China

Search for other papers by Jing Liu in
Google Scholar
PubMed
Close
,
Charles M Balch Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Charles M Balch in
Google Scholar
PubMed
Close
, and
Ning Liao Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

Search for other papers by Ning Liao in
Google Scholar
PubMed
Close

has been explored as an effective strategy to repress tumor growth, and synthetic lethal interactions have been described with PARP inhibition and CDK12 as a clinical biomarker for response in cancer treatment ( Bajrami et al. 2014 , Johnson et

Restricted access
Masaki Shiota Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Masaki Shiota in
Google Scholar
PubMed
Close
,
Momoe Itsumi Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Momoe Itsumi in
Google Scholar
PubMed
Close
,
Ario Takeuchi Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Ario Takeuchi in
Google Scholar
PubMed
Close
,
Kenjiro Imada Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan
Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Kenjiro Imada in
Google Scholar
PubMed
Close
,
Akira Yokomizo Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Akira Yokomizo in
Google Scholar
PubMed
Close
,
Hidetoshi Kuruma Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Hidetoshi Kuruma in
Google Scholar
PubMed
Close
,
Junichi Inokuchi Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Junichi Inokuchi in
Google Scholar
PubMed
Close
,
Katsunori Tatsugami Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Katsunori Tatsugami in
Google Scholar
PubMed
Close
,
Takeshi Uchiumi Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Takeshi Uchiumi in
Google Scholar
PubMed
Close
,
Yoshinao Oda Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Yoshinao Oda in
Google Scholar
PubMed
Close
, and
Seiji Naito Departments of Urology, Anatomic Pathology, Department of Urology, Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan

Search for other papers by Seiji Naito in
Google Scholar
PubMed
Close

2 995 – 1003 . ( doi:10.1158/2159-8290.CD-12-0222 ). Perry KT Anthony CT Case T Steiner MS 1997 Transforming growth factor β as a clinical biomarker for prostate cancer . Urology 49 151 – 155 . ( doi:10.1016/S0090

Free access
Y Dong
Search for other papers by Y Dong in
Google Scholar
PubMed
Close
,
L T Bui
Search for other papers by L T Bui in
Google Scholar
PubMed
Close
,
D M Odorico
Search for other papers by D M Odorico in
Google Scholar
PubMed
Close
,
O L Tan
Search for other papers by O L Tan in
Google Scholar
PubMed
Close
,
S A Myers
Search for other papers by S A Myers in
Google Scholar
PubMed
Close
,
H Samaratunga
Search for other papers by H Samaratunga in
Google Scholar
PubMed
Close
,
R A Gardiner
Search for other papers by R A Gardiner in
Google Scholar
PubMed
Close
, and
J A Clements
Search for other papers by J A Clements in
Google Scholar
PubMed
Close

clinical biomarkers. Critical Reviews in Clinical Laboratory Sciences 41 265 –312. Day CH , Fanger GR, Retter MW, Hylander BL, Penetrante RB, Houghton RL, Zhang X, McNeill PD, Filho AM, Nolasco M, Badaro R, Cheever MA, Reed

Free access
Brendan M Finnerty Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Brendan M Finnerty in
Google Scholar
PubMed
Close
,
Maureen D Moore Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Maureen D Moore in
Google Scholar
PubMed
Close
,
Akanksha Verma Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Akanksha Verma in
Google Scholar
PubMed
Close
,
Anna Aronova Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Anna Aronova in
Google Scholar
PubMed
Close
,
Shixia Huang Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA

Search for other papers by Shixia Huang in
Google Scholar
PubMed
Close
,
Dean P Edwards Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA

Search for other papers by Dean P Edwards in
Google Scholar
PubMed
Close
,
Zhengming Chen Department of Healthcare Policy & Research, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Zhengming Chen in
Google Scholar
PubMed
Close
,
Marco Seandel Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Marco Seandel in
Google Scholar
PubMed
Close
,
Theresa Scognamiglio Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Theresa Scognamiglio in
Google Scholar
PubMed
Close
,
Yi-Chieh Nancy Du Department of Pathology & Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Yi-Chieh Nancy Du in
Google Scholar
PubMed
Close
,
Olivier Elemento Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Olivier Elemento in
Google Scholar
PubMed
Close
,
Rasa Zarnegar Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Rasa Zarnegar in
Google Scholar
PubMed
Close
,
Irene M Min Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Irene M Min in
Google Scholar
PubMed
Close
, and
Thomas J Fahey III Department of Surgery, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Thomas J Fahey III in
Google Scholar
PubMed
Close

as both a clinical biomarker and potential therapeutic target in metastatic PNETs should be further investigated in prospective cohorts. Supplementary data This is linked to the online version of the paper at https://doi.org/10.1530/ERC-18

Free access
Lingfan Xu Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA

Search for other papers by Lingfan Xu in
Google Scholar
PubMed
Close
,
Enze Ma Department of Neuroscience, Duke University, Durham, North Carolina, USA

Search for other papers by Enze Ma in
Google Scholar
PubMed
Close
,
Tao Zeng Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA
Department of Urology, Jiangxi Province People’s Hospital, Nanchang, China

Search for other papers by Tao Zeng in
Google Scholar
PubMed
Close
,
Ruya Zhao Department of Dermatology, Duke School of Medicine, Durham, North Carolina, USA

Search for other papers by Ruya Zhao in
Google Scholar
PubMed
Close
,
Yulei Tao Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA

Search for other papers by Yulei Tao in
Google Scholar
PubMed
Close
,
Xufeng Chen Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA

Search for other papers by Xufeng Chen in
Google Scholar
PubMed
Close
,
Jeff Groth Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA

Search for other papers by Jeff Groth in
Google Scholar
PubMed
Close
,
Chaozhao Liang Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China

Search for other papers by Chaozhao Liang in
Google Scholar
PubMed
Close
,
Hailiang Hu Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA
Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, USA

Search for other papers by Hailiang Hu in
Google Scholar
PubMed
Close
, and
Jiaoti Huang Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA
Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, USA
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA

Search for other papers by Jiaoti Huang in
Google Scholar
PubMed
Close

significant clinical biomarker since its genomic abnormalities would link to high pretreatment LDH level and poor response to docetaxel in mCRPC ( Hiew et al . 2018 ). Furthermore, 64.3% of the patients with high LDH level were determined to have DNA repair

Free access