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Elena Valassi, Frédéric Castinetti, Amandine Ferriere, Stylianos Tsagarakis, Richard A Feelders, Romana T Netea-Maier, Michael Droste, Christian J Strasburger, Dominique Maiter, Darko Kastelan, Philippe Chanson, Susan M Webb, Frank Demtröder, Valdis Pirags, Olivier Chabre, Holger Franz, Alicia Santos, and Martin Reincke

-term outcomes of BADX, which characterize the subgroup of patients experiencing CTP-BADX/NS and identify potential clinical differences between them and their counterparts without corticotroph adenoma progression, are still lacking. Data on long-term survival in

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M Muşat, M Korbonits, B Kola, N Borboli, M R Hanson, A M Nanzer, J Grigson, S Jordan, D G Morris, M Gueorguiev, M Coculescu, S Basuand, and A B Grossman

-cycle inhibitor p27 showed that nuclear p27 protein expression in human pituitary adenomas was lower than in normal pituitary tissue, and this was especially true for corticotroph adenomas and pituitary carcinomas ( Bamberger et al. 1999 , Lidhar et al. 1999

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R van der Pas, W W de Herder, L J Hofland, and R A Feelders

hyperplasia, and gastrointestinal discomfort Pituitary-targeted drugs Drugs with proven clinical efficacy In recent years, dopamine receptors and somatostatin receptors have been identified as therapeutic targets on corticotroph adenomas ( de Bruin et al

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Luis G Perez-Rivas, Andrea Oßwald, Thomas Knösel, Kristin Lucia, Christian Schaaf, Michael Hristov, Julia Fazel, Thomas Kirchner, Felix Beuschlein, Martin Reincke, and Marily Theodoropoulou

mutated in 50% of all the investigated ACTH-producing corticotroph adenomas causing sporadic Cushing’s disease ( Ma et al. 2015 , Perez-Rivas et al. 2015 , Reincke et al. 2015 ). Mutant USP8 triggers POMC transcription and ACTH secretion through

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Odelia Cooper, George Vlotides, Hidenori Fukuoka, Mark I Greene, and Shlomo Melmed

invasive adenomas, and in 2/2 carcinomas, while metastases exhibited a higher EGF content compared with the carcinoma itself ( Lubke et al . 1995 ). Other groups reported positive EGF expression rates as high as 80% in corticotroph adenomas ( Kontogeorgos

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Dorota Dworakowska and Ashley B Grossman

for more aggressive behaviour with a higher probability of recurrence, regardless of histological grading, which include sparsely granulated somatotroph adenomas, pluri-hormonal PIT-1-positive adenomas, silent corticotroph adenomas, lactotroph adenomas

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Tullio Florio, Federica Barbieri, Renato Spaziante, Gianluigi Zona, Leo J Hofland, Peter M van Koetsveld, Richard A Feelders, Günter K Stalla, Marily Theodoropoulou, Michael D Culler, Jesse Dong, John E Taylor, Jacques-Pierre Moreau, Alexandru Saveanu, Ginette Gunz, Henry Dufour, and Philippe Jaquet

respectively ( Table 1 ). None of these adenomas exhibited ACTH- or GH-positive cells as observed in silent somatotroph or corticotroph adenomas. In six tumor fragments, foci of normal pituitary tissue were noted within the adenomatous fragments ( Table 1

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Carole Guerin, David Taieb, Giorgio Treglia, Thierry Brue, André Lacroix, Frederic Sebag, and Frederic Castinetti

recurrence after BA in two patients with Nelson's syndrome, Kemink et al . (1992) did not find any difference in recurrence rates following BA in patients with Nelson's syndrome when compared with patients without progression of their corticotroph adenomas

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Ben C Whitelaw

early (anticipatory) treatment with temozolomide are relatively rare. One case (case 1 from series) shows a corticotroph adenoma with very elevated Ki67 (50%) treated with surgery and both radiotherapy and temozolomide in quick succession ( Bengtsson et

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Adriana Albani, Luis Gustavo Perez-Rivas, Sicheng Tang, Julia Simon, Kristin Elisabeth Lucia, Paula Colón-Bolea, Jochen Schopohl, Sigrun Roeber, Michael Buchfelder, Roman Rotermund, Jörg Flitsch, Jun Thorsteinsdottir, Jochen Herms, Günter Stalla, Martin Reincke, and Marily Theodoropoulou

Inoshita N Kawaguchi K Ibrahim Ardisasmita A Suzuki H Fukuhara N Okada M Nishioka H Takeuchi Y Komada M , 2016 The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing’s disease . European Journal of