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Theodoros Karantanos General Internal Medicine Department, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA

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Styliani Karanika Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

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Gretchen Gignac Hematology-Oncology Department, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA

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( Flanagan et al . 2011 ). Obesity, hyperlipidemia, hyperinsulinemia and diabetes at the time of PCa diagnosis are associated with increased disease-associated mortality ( Hammarsten & Hogstedt 2005 , Ma et al . 2008 ). Thus, metabolic abnormalities

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Rafael Ríos Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Carmen Belén Lupiañez Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Daniele Campa Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Alessandro Martino Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Joaquin Martínez-López Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Manuel Martínez-Bueno Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Judit Varkonyi Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Ramón García-Sanz Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Krzysztof Jamroziak Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Charles Dumontet Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Andrés Jerez Cayuela Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Marzena Wętek Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Stephano Landi Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Anna Maria Rossi Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Fabienne Lesueur Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Rui Manuel Reis Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Victor Moreno Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Herlander Marques Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Artur Jurczyszyn Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Vibeke Andersen Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Ulla Vogel Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Gabriele Buda Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Enrico Orciuolo Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Svend E H Jacobsen Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Mario Petrini Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Annette J Vangsted Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Federica Gemignani Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Federico Canzian Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Manuel Jurado Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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Juan Sainz Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain

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toxins as well as type 2 diabetes (T2D) and obesity have been suggested as important mediators of the complex process of myelomagenesis ( Alexander et al . 2007 , Lope et al . 2008 , Wallin & Larsson 2011 ). Among these latter preventable factors, T2D

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Liyan Zhou Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Guiying Bai Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yue Song Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaohui Liu Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiaoqing Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yilin Deng Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yiran Si Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Yehui Shi Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Hongli Li Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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of breast cancer is increased by 20–28% in patients with diabetes, and that diabetes is an independent risk factor for poor prognosis of breast cancer ( Lu et al. 2023 ). A population-based study suggested that the breast cancer-specific mortality

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YunFeng Cui Department of Surgery, Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Surgery, Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Dana K Andersen Department of Surgery, Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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pancreatitis (CP), and diabetes mellitus (DM). The recent increase in the prevalence of type 2 DM (T2DM) is thought to have contributed to a parallel rise in the incidence of PC. Roughly half of all PC patients are found to have DM at the time of diagnosis, and

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Paolo Vigneri Section of General Pathology, Section of Endocrinology, Department of Biomedical Sciences

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Francesco Frasca Section of General Pathology, Section of Endocrinology, Department of Biomedical Sciences

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Laura Sciacca Section of General Pathology, Section of Endocrinology, Department of Biomedical Sciences

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Giuseppe Pandini Section of General Pathology, Section of Endocrinology, Department of Biomedical Sciences

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Riccardo Vigneri Section of General Pathology, Section of Endocrinology, Department of Biomedical Sciences

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Introduction Diabetes mellitus (DM) is a serious and growing health problem worldwide and is associated with severe acute and chronic complications that negatively influence both the quality of life and survival of affected individuals. Today, 250

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Xilin Yang Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Ying Wang Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Andrea O Y Luk Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Wing Yee So Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Ronald C W Ma Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Alice P S Kong Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Gang Xu Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Juliana C N Chan Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

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Introduction Diabetes is a global epidemic with rapid increase in Asia ( Chan et al . 2009 ). In China, 9.7% of adult men and women had diabetes in 2007–2008 ( Yang et al . 2010 b ). Apart from lifestyle changes, many developing areas are

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Mathis Grossmann
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Gary Wittert Department of Medicine Austin Health, Discipline of Medicine, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Introduction Diabetes and prostate cancer (PCa) are two major, growing health problems that affect millions of men worldwide. PCa is the most common solid organ cancer in men in the USA, Canada and Australia, and the second most common cancer in men

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Carolyn A Allan MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia

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Veronica R Collins MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia

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Mark Frydenberg MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia

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Robert I McLachlan MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia

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Kati L Matthiesson MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia

Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia

Department of Endocrinology Monash Health, Melbourne, Victoria, Australia

Departments of Obstetrics and Gynaecology

Surgery Monash University, Clayton, Victoria, Australia

Department of Urology

Medical Program Monash Health, Melbourne, Victoria, Australia

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cardiovascular disease (CVD) was similar to that from prostate cancer ( Ketchandji et al . 2009 ). Men with early-stage disease (representing 75% of all men diagnosed with prostate cancer) were more likely to die from CVD than prostate cancer, with diabetes and

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F Castinetti Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), and Department of Endocrinology, Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Marseille, France

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F Albarel Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), and Department of Endocrinology, Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, Centre de Référence des Maladies Rares de l’Hypophyse HYPO, Marseille, France

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F Archambeaud Service de Médecine Interne B – Endocrinologie, Limoges Cedex, France

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J Bertherat Hôpital Cochin, Service d’Endocrinologie et Maladies Métaboliques, Paris Cedex 14, France

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B Bouillet CHU Dijon, Hôpital François Mitterrand, Service d’Endocrinologie, Diabétologie, Maladies Métaboliques, Dijon Cedex, France
Unité INSERM LNC-UMR 1231, Université de Bourgogne, Dijon, France

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P Buffier CHU Dijon, Hôpital François Mitterrand, Service d’Endocrinologie, Diabétologie, Maladies Métaboliques, Dijon Cedex, France

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C Briet Institut MITOVASC, INSERM U1083, Angers University, Department of Endocrinology, Diabetology and Nutrition, University Medical Center, Angers, France

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B Cariou Department of Endocrinology, L’Institut du Thorax, CHU Nantes, Nantes, France

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Ph Caron CHU de Toulouse – Hôpital Larrey – Service d’Endocrinologie – Maladies métaboliques – Nutrition, TSA 30030, Toulouse Cedex 9, France

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O Chabre CHU de Grenoble – Hôpital Albert Michallon, Service d’Endocrinologie-Diabétologie-Nutrition, Grenoble Cedex 9, France

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Ph Chanson Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, et UMR S-1185 Faculté de Médecine Paris-Sud, University of Paris-Saclay, Le Kremlin-Bicêtre, France

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C Cortet CHRU de Lille – Hopital Huriez, Service d’Endocrinologie, Lille Cedex, France

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C Do Cao CHRU de Lille – Hopital Huriez, Service d’Endocrinologie, Lille Cedex, France

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D Drui Department of Endocrinology, L’Institut du Thorax, CHU Nantes, Nantes, France

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M Haissaguerre CHU de Bordeaux – Hôpital du Haut Lévêque, Service d’Endocrinologie-Diabétologie et Maladies Métaboliques, Pessac Cedex, France

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S Hescot Institut Curie, Oncologie Endocrinienne, Saint Cloud, France

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F Illouz Department of Endocrinology, Diabetes and Nutrition, Reference Centre of Rare Thyroid Disease, Hospital of Angers, Angers Cedex 09, France

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E Kuhn Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, et UMR S-1185 Faculté de Médecine Paris-Sud, University of Paris-Saclay, Le Kremlin-Bicêtre, France

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N Lahlou Département d’Hormonologie Spécialisée, BPR-AS, Pannes, France

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E Merlen CHRU de Lille – Hopital Huriez, Service d’Endocrinologie, Lille Cedex, France

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V Raverot Hospices Civils de Lyon, Laboratoire d’Hormonologie, Service de Biochimie et Biologie Moléculaire, Groupement Hospitalier Est, Lyon, France

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S Smati Department of Endocrinology, L’Institut du Thorax, CHU Nantes, Nantes, France

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B Verges CHU Dijon, Hôpital François Mitterrand, Service d’Endocrinologie, Diabétologie, Maladies Métaboliques, Dijon Cedex, France
Unité INSERM LNC-UMR 1231, Université de Bourgogne, Dijon, France

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F Borson-Chazot Hospices Civils de Lyon, Fédération d’Endocrinologie, Université Claude Bernard Lyon 1, Lyon, France

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the management of side effects of these treatments ( Haanen et al. 2017 ), there have been to date no recommendations from specialist societies on the management of endocrinopathies or diabetes induced by ICPI, with the exception of the management of

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Prue J Hardefeldt Sydney Medical School Nepean, The Whiteley-Martin Research Centre, Discipline of Surgery, Nepean Hospital, The University of Sydney, Level 5, South Block, PO Box 63, Penrith, New South Wales 2751, Australia

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Senarath Edirimanne Sydney Medical School Nepean, The Whiteley-Martin Research Centre, Discipline of Surgery, Nepean Hospital, The University of Sydney, Level 5, South Block, PO Box 63, Penrith, New South Wales 2751, Australia

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Guy D Eslick Sydney Medical School Nepean, The Whiteley-Martin Research Centre, Discipline of Surgery, Nepean Hospital, The University of Sydney, Level 5, South Block, PO Box 63, Penrith, New South Wales 2751, Australia

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), smoking ( Khuder et al . 2001 , Mucha et al . 2006 ) and alcohol intake ( Key et al . 2006 ), the risk associated with specific types of diabetes mellitus is yet to be determined. In a meta-analysis published in 2007, Larsson et al . reported an

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