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( Flanagan et al . 2011 ). Obesity, hyperlipidemia, hyperinsulinemia and diabetes at the time of PCa diagnosis are associated with increased disease-associated mortality ( Hammarsten & Hogstedt 2005 , Ma et al . 2008 ). Thus, metabolic abnormalities
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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Genomic Oncology Area, Hematology Department, Genomic Epidemiology Group, Department of Biology, Department of Hematology, Area of Genomic Medicine, Semmelweis University, Haematology Department, Medical University of Lodz, INSERM UMR 1052/CNRS 5286, Morales Meseguer General University Hospital, Haematoloy Clinik, INSERM, Life and Health Sciences Research Institute (ICVS), ICVS/3B's – PT Government Associate Laboratory, Molecular Oncology Research Center, IDIBELL – Catalan Institute of Oncology, Department of Hematology, Organ Center, Faculty of Health Sciences, UO Hematology, Clinic of Biochemistry and Immunology, Department of Haematology, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, 18016 Granada, Spain
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toxins as well as type 2 diabetes (T2D) and obesity have been suggested as important mediators of the complex process of myelomagenesis ( Alexander et al . 2007 , Lope et al . 2008 , Wallin & Larsson 2011 ). Among these latter preventable factors, T2D
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of breast cancer is increased by 20–28% in patients with diabetes, and that diabetes is an independent risk factor for poor prognosis of breast cancer ( Lu et al. 2023 ). A population-based study suggested that the breast cancer-specific mortality
Department of Surgery, Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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pancreatitis (CP), and diabetes mellitus (DM). The recent increase in the prevalence of type 2 DM (T2DM) is thought to have contributed to a parallel rise in the incidence of PC. Roughly half of all PC patients are found to have DM at the time of diagnosis, and
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Introduction Diabetes mellitus (DM) is a serious and growing health problem worldwide and is associated with severe acute and chronic complications that negatively influence both the quality of life and survival of affected individuals. Today, 250
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity , Li Ka Shing Institute of Health Sciences, Department of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
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Introduction Diabetes is a global epidemic with rapid increase in Asia ( Chan et al . 2009 ). In China, 9.7% of adult men and women had diabetes in 2007–2008 ( Yang et al . 2010 b ). Apart from lifestyle changes, many developing areas are
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Introduction Diabetes and prostate cancer (PCa) are two major, growing health problems that affect millions of men worldwide. PCa is the most common solid organ cancer in men in the USA, Canada and Australia, and the second most common cancer in men
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
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Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
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Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
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Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
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Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
MIMR-PHI Institute of Medical Research 27–31 Wright Street, Clayton, Victoria 3168, Australia
Andrology Australia School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Endocrinology Monash Health, Melbourne, Victoria, Australia
Departments of Obstetrics and Gynaecology
Surgery Monash University, Clayton, Victoria, Australia
Department of Urology
Medical Program Monash Health, Melbourne, Victoria, Australia
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cardiovascular disease (CVD) was similar to that from prostate cancer ( Ketchandji et al . 2009 ). Men with early-stage disease (representing 75% of all men diagnosed with prostate cancer) were more likely to die from CVD than prostate cancer, with diabetes and
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Unité INSERM LNC-UMR 1231, Université de Bourgogne, Dijon, France
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Unité INSERM LNC-UMR 1231, Université de Bourgogne, Dijon, France
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the management of side effects of these treatments ( Haanen et al. 2017 ), there have been to date no recommendations from specialist societies on the management of endocrinopathies or diabetes induced by ICPI, with the exception of the management of
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), smoking ( Khuder et al . 2001 , Mucha et al . 2006 ) and alcohol intake ( Key et al . 2006 ), the risk associated with specific types of diabetes mellitus is yet to be determined. In a meta-analysis published in 2007, Larsson et al . reported an