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Ioulia Chatzistamou Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Hippokratis Kiaris Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, South Carolina, USA
Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, Columbia, South Carolina, USA
Department of Biochemistry, University of Athens Medical School, Athens, Greece

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Estrogen receptor (ER)-positive breast cancers account for about two thirds of total breast cancer cases. Of those, about one half is diagnosed in post-menopausal women ( http://www.breastcancer.org/symptoms/understand_bc/statistics ). Hormone

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-16-0397
Volume/Issue:
Volume 23: Issue 11
Free access
Elgene Lim Garvan Institute of Medical Research and St Vincent’s Hospital, University of New South Wales, Sydney, New South Wales, Australia

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Gerard Tarulli Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide, Adelaide, South Australia, Australia

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Neil Portman Garvan Institute of Medical Research and St Vincent’s Hospital, University of New South Wales, Sydney, New South Wales, Australia

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Theresa E Hickey Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide, Adelaide, South Australia, Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide, Adelaide, South Australia, Australia

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Carlo Palmieri Institute of Translational Medicine, University of Liverpool, Clatterbridge Cancer Centre, NHS Foundation Trust, and Royal Liverpool University Hospital, Liverpool, Merseyside, UK

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Introduction There are three major sex steroid hormones – estrogen, progesterone and androgen – and each affect the signalling activity of its cognate sex steroid receptor (SSR), that is the estrogen receptor-α (ER), progesterone receptor (PR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0427
Volume/Issue:
Volume 23: Issue 12
Free access
Etienne Leygue Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9

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Leigh C Murphy Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9

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estrogen is involved in these processes continues to evolve and is more complex and multifaceted than originally thought ( Zwart et al . 2011 ). In particular, one critical discovery has been the identification of a second estrogen receptor (ER), called

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0389
Volume/Issue:
Volume 20: Issue 3
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Vanessa W Lim
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Jun Li
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Yinhan Gong
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Aizhen Jin Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore

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Jian-Min Yuan Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore
Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore

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Eu Leong Yong
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Woon-Puay Koh Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore
Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore

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circulating estrogen levels have been reported between Asian and Caucasian women ( Bernstein et al . 1990 , Shimizu et al . 1990 , Wu & Pike 1995 ). Estrogen receptor α (ERα) and ERβ bioassays are classically used to identify estrogenic compounds present

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0233
Volume/Issue:
Volume 21: Issue 2
Free access
L Zeng IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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H A Zielinska IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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A Arshad IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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J P Shield IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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A Bahl IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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J M P Holly IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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C M Perks IGFs and Metabolic Endocrinology Group, Department of Clinical Oncology, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK

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for all subtypes of breast cancer. In a study of women involved in three large trials, inferior disease-free survival and worse overall survival was only identified in women with estrogen receptor (ERα) positive breast cancer and not for other subtypes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0507
Volume/Issue:
Volume 23: Issue 2
Free access
Tesa M Severson Division of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands
Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, Amsterdam, the Netherlands

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Wilbert Zwart Division of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands

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genders and specific gene products. Breast cancer is almost automatically linked with female and estrogen receptor alpha (ERα) action. Although this is intrinsically true, it is by far not the full story, as breast cancer is neither gender-exclusive nor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0225
Volume/Issue:
Volume 24: Issue 3
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Yumi Endo Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Tatsuya Toyama Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Satoru Takahashi Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Nobuyasu Yoshimoto Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Mai Iwasa Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Tomoko Asano Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Yoshitaka Fujii Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Hiroko Yamashita Departments of Oncology, Experimental Pathology and Tumor Biology, Immunology and Surgery

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Introduction There are large-scale molecular differences between estrogen receptor α (ERα)-positive and ER-negative breast cancers ( Sorlie et al . 2003 ). ER is essential for estrogen-dependent growth, and its level of expression is a crucial

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0207
Volume/Issue:
Volume 20: Issue 1
Free access
Srilatha Swami
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Aruna V Krishnan
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Lihong Peng
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Johan Lundqvist Division of Endocrinology, Breast Cancer Group, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Room S025, Stanford, California 94305-5103, USA

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David Feldman
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Introduction Breast cancer (BCa) is the most common cancer in women in the USA ( Siegel et al . 2012 ). Estrogens drive the proliferation of mammary epithelial cells and therefore promote the growth of estrogen receptor-positive (ER+) BCa cells

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0281
Volume/Issue:
Volume 20: Issue 4
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Tobias Zellweger
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Susanne Stürm Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Silvia Rey Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Inti Zlobec Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Joel R Gsponer Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Cyrill A Rentsch Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland
Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Luigi M Terracciano Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Alexander Bachmann Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Lukas Bubendorf Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Christian Ruiz Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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the role of the AR and the two estrogen receptors ERα and ERβ in the context of PC progression, we performed a comprehensive analysis of their expression (AR, ERα and ERβ), phosphorylation (pAR 210 ) and genomic amplification status ( AR ) in a cohort

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0402
Volume/Issue:
Volume 20: Issue 3
Free access
Leigh C Murphy Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Deeley Research Centre, Faculty of Medicine

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Srinivas V Seekallu Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Deeley Research Centre, Faculty of Medicine

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Peter H Watson Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Deeley Research Centre, Faculty of Medicine

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Introduction Targeting the estrogen receptor (ER) signaling pathway using the selective ER modulator (SERM), tamoxifen, is efficacious in both treating and preventing breast cancer ( Jensen & Jordan 2003 , Jordan 2003 ). Owing to the central role

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0070
Volume/Issue:
Volume 18: Issue 1
Free access