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Jie Cai School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Lin Li School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Lei Ye School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Xiaohua Jiang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Liyun Shen School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Zhibo Gao School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Weiyuan Fang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Fengjiao Huang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Tingwei Su School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Yulin Zhou School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Weiqing Wang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Guang Ning School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China
School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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). Concurrent RAS mutation was found exclusively in non-RET mutated MTCs via exome sequencing ( Agrawal et al . 2013 ). Other MTC-associated loci that have been reported include P18 , Sprouty1 , NRAS , and others ( Takahashi et al . 2006 , Van Veelen et

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Yuanliang Li Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yiying Guo Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Zixuan Cheng Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Chao Tian Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yingying Chen Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Ruao Chen Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Fuhuan Yu Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yanfen Shi Department of Pathology, China-Japan Friendship Hospital, Beijing, China

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Fei Su Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

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Shuhua Zhao Department of Biological Information Research, HaploX Biotechnology Co., Ltd, Shenzhen, Guangdong, China

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Zhizheng Wang Academic Department, HaploX Biotechnology, Co., Ltd, Shenzhen, Guangdong, China

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Jie Luo Department of Pathology, China-Japan Friendship Hospital, Beijing, China

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Huangying Tan Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

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et al. 2011 , Scarpa et al. 2017 ), small intestine ( Banck et al. 2013 , Francis et al. 2013 ), and lung ( Gabriel et al. 2020 ), while the genomic data based on whole-exome sequencing in R-NETs was absent. Evidence has shown that the

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Tobias Hofving Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Yvonne Arvidsson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Bilal Almobarak Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Linda Inge Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Roswitha Pfragner Institute of Pathophysiology and Immunology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Marta Persson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Göran Stenman Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Erik Kristiansson Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

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Viktor Johanson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Ola Nilsson Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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-derived cell lines BON-1 and QGP-1 by exome sequencing and genome-wide copy number analysis. These studies have raised questions regarding their relevance as models due to the absence of PanNET-associated mutations ( Boora et al . 2015 , Vandamme et al

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Angel Chao Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Huei-Jean Huang Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Chiao-Yun Lin Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Chia-Hwa Lee Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Chien-Hsing Lin Taiwan Genomic Industry Alliance Inc., Taipei, Taiwan

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An-Shine Chao Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Department of Obstetrics and Gynecology, New Taipei Municipal Tu Cheng Hospital, New Taipei City, Taiwan

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Chyong-Huey Lai Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Ting-Chang Chang Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Kai-Yun Wu Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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Ren-Chin Wu Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

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have conducted the first comprehensive analysis of the genetic landscape of this uncommon ovarian tumor using TruSight Oncology (TSO) 500 testing and/or whole-exome sequencing (WES). Furthermore, a detailed clinicopathological illustration of a

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Antonio M Lerario Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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Kazutaka Nanba Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Amy R Blinder Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Sachiko Suematsu Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan

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Masao Omura Medical Checkup Clinic, Minatomirai Medical Square, Sowa-Group, Yokohama, Japan

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Tetsuo Nishikawa Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan

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Thomas J Giordano Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA

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William E Rainey Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Tobias Else Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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secondary mutations in growth-promoting genes have been reported in APA with mutations in aldosterone-driver genes so far. In this study, we used whole-exome sequencing (WES) to characterize the landscape of somatic alterations in a homogeneous series of

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Eleanor L Woodward Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Andrea Biloglav Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Naveen Ravi Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Minjun Yang Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Lars Ekblad Division of Oncology and Pathology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

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Johan Wennerberg Division of Otorhinolaryngology/Head and Neck Surgery, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

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Kajsa Paulsson Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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investigated the genetic landscape of ATC cell lines using SNP array analysis, RNA sequencing and whole exome sequencing (WES). We found that ATC cell lines display highly complex genomes, with multiple breakpoints and large variation in copy numbers. We

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Kelly Brewer Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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Jessica Costa-Guda Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA

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Andrew Arnold Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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expressing the truncated LRP5 exhibited increased Wnt-mediated transcriptional activity, suggesting that the alternate transcript may be more effective in sequestering the β-catenin destruction complex. A single case within a whole-exome sequencing cohort

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Yuji Ikeda Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Kazuma Kiyotani Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Poh Yin Yew Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Taigo Kato Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Kenji Tamura Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Kai Lee Yap Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Sarah M Nielsen Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Jessica L Mester Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Charis Eng Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Yusuke Nakamura Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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Raymon H Grogan Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA

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whole-exome sequencing. Materials and methods Samples The study cohort consisted of 14 women known to have both primary breast and thyroid cancer malignancies. They were identified from a cohort of study participants who consented to participate in

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A Karpathakis University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK
University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK

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H Dibra University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK

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C Thirlwell University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK
University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK

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discovery of mutations in the novel tumour suppressor genes and chromatin remodellers ATRX/DAXX through exome sequencing represent significant progress in our understanding of neuroendocrine tumour (NET) development. NETs are a heterogenous group of

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Rodrigo A Toledo Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Yuejuan Qin Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Subramanya Srikantan Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Nicole Paes Morales Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Qun Li Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Yilun Deng Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Sang-Woo Kim Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Maria Adelaide A Pereira Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Sergio P A Toledo Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Xiaoping Su Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Ricardo C T Aguiar Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA
Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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Patricia L M Dahia Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA
Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA

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obtained from blood or adjacent normal tissue. DNA and RNA isolation Blood and tumor DNA and RNA were isolated using Qiagen kits or Trizol respectively following the manufacturers' protocols. Exome sequencing We performed whole exome sequencing of matched

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