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School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China
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). Concurrent RAS mutation was found exclusively in non-RET mutated MTCs via exome sequencing ( Agrawal et al . 2013 ). Other MTC-associated loci that have been reported include P18 , Sprouty1 , NRAS , and others ( Takahashi et al . 2006 , Van Veelen et
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Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China
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et al. 2011 , Scarpa et al. 2017 ), small intestine ( Banck et al. 2013 , Francis et al. 2013 ), and lung ( Gabriel et al. 2020 ), while the genomic data based on whole-exome sequencing in R-NETs was absent. Evidence has shown that the
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-derived cell lines BON-1 and QGP-1 by exome sequencing and genome-wide copy number analysis. These studies have raised questions regarding their relevance as models due to the absence of PanNET-associated mutations ( Boora et al . 2015 , Vandamme et al
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Department of Obstetrics and Gynecology, New Taipei Municipal Tu Cheng Hospital, New Taipei City, Taiwan
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Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
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have conducted the first comprehensive analysis of the genetic landscape of this uncommon ovarian tumor using TruSight Oncology (TSO) 500 testing and/or whole-exome sequencing (WES). Furthermore, a detailed clinicopathological illustration of a
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Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
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Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
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secondary mutations in growth-promoting genes have been reported in APA with mutations in aldosterone-driver genes so far. In this study, we used whole-exome sequencing (WES) to characterize the landscape of somatic alterations in a homogeneous series of
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investigated the genetic landscape of ATC cell lines using SNP array analysis, RNA sequencing and whole exome sequencing (WES). We found that ATC cell lines display highly complex genomes, with multiple breakpoints and large variation in copy numbers. We
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Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA
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Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut, USA
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expressing the truncated LRP5 exhibited increased Wnt-mediated transcriptional activity, suggesting that the alternate transcript may be more effective in sequestering the β-catenin destruction complex. A single case within a whole-exome sequencing cohort
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Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
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whole-exome sequencing. Materials and methods Samples The study cohort consisted of 14 women known to have both primary breast and thyroid cancer malignancies. They were identified from a cohort of study participants who consented to participate in
University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK
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University College London Cancer Institute, Neuroendocrine Tumour Unit, 72 Huntley Street, London WC1E 6BT, UK
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discovery of mutations in the novel tumour suppressor genes and chromatin remodellers ATRX/DAXX through exome sequencing represent significant progress in our understanding of neuroendocrine tumour (NET) development. NETs are a heterogenous group of
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Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA
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Division of Hematology and Medical Oncology, Greehey Children Cancer Research Institute, University of São Paulo School of Medicine, Department of Bioinformatics and Computational Biology, Department of Medicine, Cancer Therapy and Research Center at the University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7880, San Antonio, Texas 78229-3900, USA
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obtained from blood or adjacent normal tissue. DNA and RNA isolation Blood and tumor DNA and RNA were isolated using Qiagen kits or Trizol respectively following the manufacturers' protocols. Exome sequencing We performed whole exome sequencing of matched