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Zhe Wang, Ke Ma, Steffie Pitts, Yulan Cheng, Xi Liu, Xiquan Ke, Samuel Kovaka, Hassan Ashktorab, Duane T Smoot, Michael Schatz, Zhirong Wang, and Stephen J Meltzer

Introduction Gastric carcinoma (GC) is the fourth most common cancer and third leading cause of cancer death worldwide ( Fitzmaurice et al . 2015 ). Although research on GC has progressed substantially, its 5-year overall survival (OS) rate

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R Fossmark, T C Martinsen, S H Torp, S Kawase, A K Sandvik, and H L Waldum

Among inbred female cotton rats (Sigmodon hispidus) 25-50% of the animals develop spontaneous gastric carcinomas; the corresponding figure for male cotton rats is approximately 1%. Animals with carcinomas have hypergastrinaemia and gastric hypo-anacidity and the tumours are derived from enterochromaffin-like (ECL) cells. The mechanism behind the hypo-anacidity is unknown. Carcinomas are found in all female cotton rats with hypergastrinaemia lasting more than 4 months and this represents an excellent animal model for studying gastric carcinogenesis. In this study, the somatostatin analogue octreotide was given to female cotton rats to prevent carcinoma development caused by hypergastrinaemia. Twelve female cotton rats were given monthly injections of long-acting octreotide (5 mg i.m.) for 6 months. A control group of 20 animals was not given injections. Of the 20 control animals, 13 developed hypergastrinaemia and histologically invasive carcinomas or dysplasia. Of the 12 animals in the octreotide group, five developed hypergastrinaemia. None of these five animals developed histological cancer (P<0.05), whereas three had dysplasia. However, octreotide did not affect plasma gastrin concentration or antral gastrin mRNA abundance significantly. Dysplasia of the oxyntic mucosa in hypergastrinaemic animals was accompanied by a marked increase in chromogranin A-immunoreactive cells and cells positive for Sevier-Munger staining. The malignant tissue also contained groups of cells with Sevier-Munger staining. In conclusion, octreotide prevented ECL cell carcinomas in hypergastrinaemic cotton rats without lowering the gastrin concentration.

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Yu-Xia Chen, Yan Wang, Chen-Chun Fu, Fei Diao, Liang-Nian Song, Zong-Bin Li, Rui Yang, and Jian Lu

. 1998 ) and human cytotrophoblast ( Ryu et al . 1999 ), while they were induced in human gastric carcinoma cells ( Murakami et al . 1998 ) by Dex. But there is no information about how Dex affects the expression of integrin β1 in ovarian cancer

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Cuiqi Zhou, Yunguang Tong, Kolja Wawrowsky, Serguei Bannykh, Ines Donangelo, and Shlomo Melmed

cellular stress-induced genes ( Tantin et al . 2005 ). Oct-1 might also play a role in tumorigenesis, as Oct-1 expression is enhanced in intestinal metaplasia and gastric carcinomas ( Almeida et al . 2005 ). In this study, we detected two putative Oct-1

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Yong Lin, Xiaofei Jiang, Ye Shen, Min Li, Huili Ma, Mingzhao Xing, and Yuan Lu

), gastric carcinoma ( Byun et al . 2003 ), esophageal adenocarcinoma ( Miller et al . 2003 ), thyroid tumors ( Wu et al . 2005 ), oral squamous cell carcinoma ( Kozaki et al . 2006 ), head and neck squamous cell carcinoma ( Qiu et al . 2006 ), and anal

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V Häyry, K Salmenkivi, J Arola, P Heikkilä, C Haglund, and H Sariola

Yoshiura K Shimoyama Y Birchmeier W Sugimura T Hirohashi S 1994 E-cadherin gene mutations in human gastric carcinoma cell lines . PNAS 91 1858 – 1862 . Ohta S Lai EW Pang ALY Brouwers FM Chan WY Eisenhofer G de Krijger R

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Carlos J P Álvarez, María Lodeiro, Marily Theodoropoulou, Jesús P Camiña, Felipe F Casanueva, and Yolanda Pazos

, Carlini et al . 2007 , Samson et al . 2007 , Zizzari et al . 2007 ). Among them, it is remarkable that the mitogenic effect described for obestatin in human retinal pigment epithelial cells (hRPE; Camiña et al . 2007 a ), human gastric carcinoma

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Yumi Endo, Tatsuya Toyama, Satoru Takahashi, Nobuyasu Yoshimoto, Mai Iwasa, Tomoko Asano, Yoshitaka Fujii, and Hiroko Yamashita

reported that six miRNAs, including miR-1290, were upregulated in drug-sensitive cells following Y-Box protein 1 inhibition, but no differences in miRNA expression could be detected in multidrug-resistant gastric carcinoma cells ( Belian et al . 2010

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Martine J Hollestelle, Peter Timmerman, Rob H Meloen, and Jo W M Höppener

in gastric carcinoma . European Journal of Surgical Oncology 30 536 – 543 . Haigh CR Attwood SE Thompson DG Jankowski JA Kirton CM Pritchard DM Varro A Dimaline R 2003 Gastrin induces proliferation in Barrett's metaplasia through

Open access

G Azizi, J M Keller, M Lewis, K Piper, D Puett, K M Rivenbark, and C D Malchoff

HBV or HCV hepatitis and liver carcinoma; iii) Heliobacter pylori -induced chronic gastritis and gastric carcinoma; iv) asbestosis and mesothelioma; v) chronic obstructive pulmonary disease and lung cancer; and vi) scleroderma and carcinoma of the