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Lisa D Berman-Booty Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Karen E Knudsen Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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the major xenograft and genetically engineered mouse models of NePC. We have described the xenograft models and detailed the lesions that the genetically engineered mice develop, their disease progression, and how genetic manipulation of some of these

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Sarah A Dabydeen Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA

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Priscilla A Furth Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA
Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA

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commonly ER+ include invasive lobular, papillary, and tubular. Not all of the published studies that report the development of genetically engineered mice provide sufficient detail to be able to definitively assign the histopathology developing in the mouse

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Sahar J Alothman Graduate School of Arts and Science, Georgetown University, Washington, District of Columbia, USA
Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Weisheng Wang Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Shan Chao Graduate School of Arts and Science, Georgetown University, Washington, District of Columbia, USA
Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Bhaskar V Kallakury Department of Pathology, Georgetown University, Washington, District of Columbia, USA
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

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Edgar S Díaz-Cruz Department of Oncology, Georgetown University, Washington, District of Columbia, USA
College of Pharmacy, Belmont University, Nashville, Tennessee, USA

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Priscilla A Furth Department of Oncology, Georgetown University, Washington, District of Columbia, USA
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
Department of Medicine, Georgetown University, Washington, District of Columbia, USA

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Dear Editor, The impact of oral peroxisome proliferator-activated receptor gamma agonist (PPARG) efatutazone exposure through diet on mammary preneoplasia and cancer development was evaluated in genetically engineered mice carrying one vs two

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Caroline Wilson Academic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Sheffield, UK

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Hannah Brown Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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Ingunn Holen Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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proximity to osteoblasts and blood vessels in mouse bone. Genetically engineered mice with GFP-expressing osteoblasts injected via the intracardiac route with CMDii-labelled human MDA-MB-231 cells before sample collection and processing for paraffin sections

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Maho Shibata Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA

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Michael M Shen Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA

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). Shappell SB Thomas GV Roberts RL Herbert R Ittmann MM Rubin MA Humphrey PA Sundberg JP Rozengurt N Barrios R 2004 Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the

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Estefania Labanca Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Elba S Vazquez Laboratorio de Inflamación y Cáncer, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina

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Paul G Corn Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Justin M Roberts Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Fen Wang Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA

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Christopher J Logothetis Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Nora M Navone Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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stage of maturation of the target cells, and the microenvironment (e.g. availability of HS). Genetically engineered mice (GEM) studies shed some light on the role of the FGF axis in bone biology. Both genes, Fgfr1 and Fgfr2 , are expressed in the

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Kristen Wong Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Francesca Di Cristofano Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Michela Ranieri Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Daniela De Martino Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Antonio Di Cristofano Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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indicated in Table 1 . Mouse cell lines were established from ATCs developed by genetically engineered mice ( Antico Arciuch et al . 2011 , Dima et al . 2011 ). Cell line identity was validated by STS profiling as well as by amplifying and sequencing

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Yu-Yu Liu The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA

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Michael P Brandt The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA

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Daniel H Shen The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA

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Richard T Kloos The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA

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Xiaoli Zhang The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA

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Sissy M Jhiang The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
The Ohio State Biochemistry Program, Molecular, Department of Nuclear Medicine, Department of Physiology and Cell Biology, Thyroid Cancer Unit, Center for Biostatistics, Department of Internal Medicine, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA

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-competent genetically engineered mice carrying thyroid tumors surrounded by physiologically/pathologically relevant microenvironment. Our laboratory has previously reported that 17-allyamino-17-demothoxygeldanamycin (17-AAG) increases NIS-mediated radioiodine

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R Serra Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, USA

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M R Crowley Department of Cell Biology, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, USA

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injectable drugs in the treatment of breast cancer with few adverse effects. Summary Genetically engineered mice have been used to determine the role and mechanism of TGF-β signaling in normal breast physiology and pathology. DNA

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Berna C Özdemir Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
International Cancer Prevention Institute, Epalinges, Switzerland

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George Sflomos ISREC – Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland

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Cathrin Brisken International Cancer Prevention Institute, Epalinges, Switzerland
ISREC – Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland

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Frech SM Nakles RE Diaz-Cruz ES Shiffert MT Furth PA 2012 Association of over-expressed estrogen receptor alpha with development of tamoxifen resistant hyperplasia and adenocarcinomas in genetically engineered mice. Anatomy and Physiology

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