Search Results

You are looking at 1 - 10 of 261 items for :

  • "glucocorticoids" x
  • Refine by Access: All content x
Clear All
Free access

Isabel Mayayo-Peralta, Wilbert Zwart, and Stefan Prekovic

-integration, and immune system function ( Guyton & Hall 2006 ). Among the members of this group is the glucocorticoid receptor (GR), specialized toward high-affinity sensing of glucocorticoids (GCs), hormones produced in the adrenal cortex. First evidence

Restricted access

Andrew E Greenstein, Mouhammed Amir Habra, Subhagya A Wadekar, and Andreas Grauer

Introduction Elevated glucocorticoid (GC) activity (hypercortisolism) has been implicated in the pathophysiology of multiple cancer types, including breast, ovarian, squamous cell and cervical cancer, and lymphomas ( Mormont & Lévi 1997

Open access

Jan Kroon, Martin Puhr, Jeroen T Buijs, Geertje van der Horst, Daniëlle M Hemmer, Koen A Marijt, Ming S Hwang, Motasim Masood, Stefan Grimm, Gert Storm, Josbert M Metselaar, Onno C Meijer, Zoran Culig, and Gabri van der Pluijm

underlying molecular mechanisms of docetaxel resistance is of a pivotal importance to combat docetaxel resistance in clinics ( Madan et al . 2011 ). The glucocorticoid receptor (GR) is a receptor that, upon binding of glucocorticoids (GCs) (e

Free access

G Schlossmacher, E Platt, A Davies, S Meredith, and A White

inhibition by glucocorticoids (Gcs), and this is the basis of the high-dose dexamethasone (Dex) suppression test in the diagnosis of Cushing's syndrome ( Newell-Price et al . 2006 ). The inability of Gcs to inhibit POMC expression in SCLC led to the

Open access

Paula Sommer, Rachel L Cowen, Andrew Berry, Ann Cookson, Brian A Telfer, Kaye J Williams, Ian J Stratford, Paul Kay, Anne White, and David W Ray

glucocorticoids (Gcs), which is evidence of Gc resistance ( White et al . 1990 , White & Clark 1993 ). Gcs are vital steroid hormones with wide-ranging effects on cells and tissues, playing key roles in diverse actions such as development and

Free access

Sisi Liu, Emmanouil Saloustros, Annabel Berthon, Matthew F Starost, Isabelle Sahut-Barnola, Paraskevi Salpea, Eva Szarek, Fabio R Faucz, Antoine Martinez, and Constantine A Stratakis

glucocorticoid production from affected glands. Our data support this hypothesis, as both in vitro and in vivo celecoxib decreased steroidogenesis and reversed, at least in part, BAH in the treated animals. Materials and methods Animal protocol AdKO mice have

Free access

Pushpa Patel, Rowan Hardy, Vaiyapuri Sumathi, Gillian Bartle, Lars-Gunnar Kindblom, Robert Grimer, Iwona Bujalska, Paul M Stewart, Elizabeth Rabbitt, Neil J L Gittoes, and Mark S Cooper

lineage. Normal osteoblasts are highly sensitive to glucocorticoids, which have anti-proliferative, pro-differentiative and pro-apoptotic actions on these cells ( Cooper 2004 , O'Brien et al . 2004 ). The detrimental effects of therapeutic

Open access

Ville Paakinaho and Jorma J Palvimo

cancers whose development and growth are initially steroid hormone-dependent ( Metcalfe et al. 2018 , Dhiman et al. 2018 ). The family of SRs consists of estrogen receptor (ER), and 3-ketosteroid receptors (NR3Cs), glucocorticoid (GR, NR3C1

Free access

Alba Jiménez-Panizo, Paloma Pérez, Ana M Rojas, Pablo Fuentes-Prior, and Eva Estébanez-Perpiñá

), the glucocorticoid receptor (GR/NR3C1), the mineralocorticoid receptor (MR/NR3C2) and the progesterone receptor (PR/NR3C3). Phylogenetic studies show that AR, GR, MR and PR comprise a subfamily of so-called oxosteroid NRs, which markedly differ from

Free access

Yu-Xia Chen, Yan Wang, Chen-Chun Fu, Fei Diao, Liang-Nian Song, Zong-Bin Li, Rui Yang, and Jian Lu

Introduction Glucocorticoids (GCs) are being used in the treatment of childhood leukemia for several decades ( Frei et al . 1965 ), and they have become one of the common drugs in almost all chemotherapy protocols for lymphoid malignancies