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Reetobrata Basu Edison Biotechnology Institute, Athens, Ohio, USA

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John J Kopchick Edison Biotechnology Institute, Athens, Ohio, USA
Molecular and Cellular Biology Program, Ohio University, Athens, Ohio, USA
Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA

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growth hormone (GH) and the insulin-like growth factor 1 (IGF1) axis. Massive amount of research over the last 70 years have established that GH and IGF1 have both overlapping and mutually exclusive roles in driving multiple aspects of cancer initiation

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0414
Volume/Issue:
Volume 30: Issue 9
Free access
Paul C Marker School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Christopher J Unterberger School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Steven M Swanson School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Introduction Investigation of the role of growth hormone (GH) and its downstream mediators including insulin-like growth factor 1 (IGF-1) in the initiation and progression of cancer has been motivated by several factors including low cancer

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0403
Volume/Issue:
Volume 30: Issue 5
Free access
Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center, Petah Tikva, Israel

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Haim Werner Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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The growth hormone–insulin-like growth factor endocrine system The growth hormone (GH)–insulin-like growth factor-1 (IGF-1) endocrine system plays an essential role in the regulation of multiple metabolic and growth processes throughout life

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0394
Volume/Issue:
Volume 30: Issue 9
Free access
Yue Wang Liggins Institute, University of Auckland, Auckland, New Zealand
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand

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Stephen M F Jamieson Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand
Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand

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Jo K Perry Liggins Institute, University of Auckland, Auckland, New Zealand
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand

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Introduction Observations in humans and animals with elevated or disrupted growth hormone (GH) signalling clearly support a role for GH in cancer development ( Guevara-Aguirre et al. 2020 , Werner et al. 2020 , Duran-Ortiz et al. 2021

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-23-0033
Volume/Issue:
Volume 30: Issue 9
Free access
Thomas Cuny Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France

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Caroline Zeiller Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France

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Martin Bidlingmaier Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany

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Céline Défilles Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France

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Catherine Roche APHM, Conception, Laboratory of Molecular Biology, Marseille, France

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Marie-Pierre Blanchard Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France

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Marily Theodoropoulou Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany

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Thomas Graillon Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM Timone, Department of Neurosurgery, Marseille, France

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Morgane Pertuit APHM, Conception, Laboratory of Molecular Biology, Marseille, France

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Dominique Figarella-Branger APHM Timone, Laboratory of Neuropathology and Aix-Marseille University, INSERM, CRO2 UMR911, Marseille, France

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Alain Enjalbert Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM, Conception, Laboratory of Molecular Biology, Marseille, France

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Thierry Brue Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM Conception, Department of Endocrinology, Marseille, France

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Anne Barlier Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM, Conception, Laboratory of Molecular Biology, Marseille, France

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Introduction Acromegaly is a rare disease with a prevalence of around 40–130 cases per million inhabitants ( Chanson et al. 2014 ). It is caused by oversecretion of the growth hormone (GH), mainly by a pituitary GH-secreting adenoma

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0140
Volume/Issue:
Volume 23: Issue 7
Open access
Maura Fanti Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA

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Valter D Longo Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA

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. 2020 , Cortellino et al. 2022 , Ligorio et al. 2022 ). These effects of fasting/FMD on normal and cancer cells are mediated at least in part by the reduction in growth hormone (GH) and insulin-like-growth-factor-I (IGF-1) signaling. Chronic CR can

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0048
Volume/Issue:
Volume 31: Issue 11
Restricted access
Xi Zhang Shenzhen Bay Laboratory, Shenzhen, P R China

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Vijay Pandey Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Vipul Bhardwaj Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Tao Zhu Shenzhen Bay Laboratory, Shenzhen, P R China
Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P R China
The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P R China

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Peter E Lobie Shenzhen Bay Laboratory, Shenzhen, P R China
Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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00726-018-2581-z ) Coker-Gurkan A Bulut D Genc R Arisan ED Obakan-Yerlikaya P & Palavan-Unsal N 2019 Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-23-0120
Volume/Issue:
Volume 31: Issue 1
Restricted access
Verónica A Bahamondes Lorca Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile

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Shiyong Wu Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA

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endocrine gland located in the base of the brain, the secretory function of which is impaired by ionizing radiation. In normal conditions, the anterior pituitary gland secretes growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0371
Volume/Issue:
Volume 31: Issue 3
Restricted access
W Patricia Bandettini National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Alexander S Karageorgiadis National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA
Department of Pediatrics, Georgetown University Hospital, Washington, District of Columbia, USA

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Ninet Sinaii Biostatistics and Clinical Epidemiology Service, Clinical Center, NIH, Bethesda, Maryland, USA

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Douglas R Rosing National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Vandana Sachdev National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Marie Helene Schernthaner-Reiter National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA

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Evgenia Gourgari National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA
Department of Pediatrics, Georgetown University Hospital, Washington, District of Columbia, USA

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Georgios Z Papadakis Department of Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, Maryland, USA

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Meg F Keil National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA

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Charalampos Lyssikatos National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA

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J Aidan Carney Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

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Andrew E Arai National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Maya Lodish National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA

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Constantine A Stratakis National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA

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1α of the cyclic AMP-dependent protein kinase A ( Stratakis et al . 2001 ). The most common endocrine tumors in CNC are primary pigmented nodular adrenocortical disease (PPNAD) and growth hormone (GH) and prolactin-producing pituitary adenomas

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0246
Volume/Issue:
Volume 23: Issue 9
Free access
Cesar Luiz Boguszewski Department of Internal Medicine, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Margaret Cristina da Silva Boguszewski Department of Pediatrics, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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between growth hormone (GH) and glucose homeostasis ( Houssay & Biassotti 1930 , de Herder 2014 ). Subsequently, after several decades of research, species-specific pituitary GHs were synthesized by Evans' disciple, the Chinese-born American chemist Choh

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0400
Volume/Issue:
Volume 30: Issue 4
Free access