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Ran Rostoker Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Sagi Abelson Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Keren Bitton-Worms Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Inna Genkin Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Sarit Ben-Shmuel Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Maria Dakwar Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Zila Shen Orr Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Avishay Caspi Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Maty Tzukerman Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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Derek LeRoith Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel
Clinical Research Institute at Rambam (CRIR) and the Faculty of Medicine, The Laboratory of Molecular Medicine, Division of Endocrinology, Technion, Diabetes and Metabolism Clinical Research Center of Excellence, Haifa, Israel

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277 – 289 . ( doi:10.1007/s10911-013-9303-7 ). Belfiore A Frittitta L Costantino A Frasca F Pandini G Sciacca L Goldfine I Vigneri R 1996 Insulin receptors in breast cancer . Annals of the New York Academy of Sciences 784 173

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0490
Volume/Issue:
Volume 22: Issue 2
Free access
Carolin Maria Frisch
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Katrin Zimmermann
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Pia Zilleßen Institute of Pharmacology and Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany

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Alexander Pfeifer
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Kurt Racké
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Peter Mayer Institute of Pharmacology and Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany

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. 2009 ). However, recent studies give evidence that the insulin receptor (IR) itself plays a crucial role in malignancies ( Frasca et al . 2008 ). Importantly, Kim et al . (2012) further revealed for the first time the impact of IR in survival of non

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0581
Volume/Issue:
Volume 22: Issue 4
Free access
Antonino Belfiore Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy

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Roberta Malaguarnera Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy

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Introduction The insulin receptor (IR) and the IGF1 receptor (IGF1R), both evolved from a common ancestor gene, represent fundamental regulators of glucose metabolism and growth, respectively, in response to nutrient availability. It is now well

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0074
Volume/Issue:
Volume 18: Issue 4
Free access
Zara Zelenko Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Emily Jane Gallagher Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Irini Markella Antoniou Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Deepali Sachdev Department of Medicine and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA

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Anupma Nayak Department of Pathology and Laboratory Medicine, The Mount Sinai Hospital and Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Douglas Yee Department of Medicine and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA

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Derek LeRoith Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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endogenous hyperinsulinemia profoundly increased the growth of human LCC6 cancers and that insulin receptor knockdown led to significantly decreased tumor growth in control and hyperinsulinemic mice. Furthermore, the knockdown of the insulin receptor led to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0142
Volume/Issue:
Volume 23: Issue 9
Free access
Dawei Wu Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Dongwei Lv Department of Sports Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Ting Zhang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Lianying Guo Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Fangli Ma Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Caihua Zhang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Guofeng Lv Department of Sports Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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Lin Huang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China

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patients is associated with hyperinsulinemia which stimulates the proliferation of epithelial cells ( Gualberto & Pollak 2009 , Pollak 2012 ). The holo-insulin receptor (IR) formation and the signaling of IR pathway is activated by IGF1R depletion ( Zhang

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0370
Volume/Issue:
Volume 26: Issue 2
Open access
Gail E de Blaquière The Medical School, Northern Institute for Cancer Research, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Felicity E B May The Medical School, Northern Institute for Cancer Research, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Bruce R Westley The Medical School, Northern Institute for Cancer Research, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

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Introduction The insulin-like growth factor (IGF) system comprises two ligands (IGF-1 and IGF-2) as well as the closely related hormone insulin, six binding proteins (IGFBP1-6), three receptors (type I and type II IGF and the insulin receptors) and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0216
Volume/Issue:
Volume 16: Issue 2
Free access
V Costa
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D Foti
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F Paonessa
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E Chiefari
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L Palaia
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G Brunetti Dipartimento di Medicina Sperimentale e Clinica ‘G. Salvatore’, Dipartimento di Scienze Biomolecolari e Biotecnologie, Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Catanzaro ‘Magna Græcia’, 88100 Catanzaro, Italy

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E Gulletta
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A Fusco Dipartimento di Medicina Sperimentale e Clinica ‘G. Salvatore’, Dipartimento di Scienze Biomolecolari e Biotecnologie, Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Catanzaro ‘Magna Græcia’, 88100 Catanzaro, Italy

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A Brunetti
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peptide hormone insulin is a major regulator of glucose homeostasis and cell growth. The first step in insulin action is the binding of the hormone to the insulin receptor (IR), a phylogenetically ancient receptor protein embedded in the plasma membrane of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0226
Volume/Issue:
Volume 15: Issue 1
Free access
Carly Jade Dool
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Haider Mashhedi
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Mahvash Zakikhani
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Stéphanie David
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Yunhua Zhao
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Elena Birman
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Joan M Carboni Department of Oncology, Oncology Drug Discovery, Lady Davis Research Institute of the Jewish General Hospital and Department of Oncology, McGill University, 3755 Cote-Ste-Catherine, Montreal, Quebec, Canada H3T 1E2

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Marco Gottardis Department of Oncology, Oncology Drug Discovery, Lady Davis Research Institute of the Jewish General Hospital and Department of Oncology, McGill University, 3755 Cote-Ste-Catherine, Montreal, Quebec, Canada H3T 1E2

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Marie-José Blouin
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Michael Pollak
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Introduction Experimental evidence that certain cancers are mitogenically responsive to insulin has been available for decades ( Heuson et al . 1967 ) and is consistent with recent work demonstrating growth inhibitory effects of insulin receptor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0136
Volume/Issue:
Volume 18: Issue 6
Free access
W Solarek Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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A M Czarnecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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B Escudier Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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Z F Bielecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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F Lian Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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C Szczylik Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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tetrameric complex, characterized by two halves, which consist of an extracellular α-chain that is involved in ligand binding and an intracellular β-chain with functional tyrosine kinase (TK) domain. In adult tissues, insulin receptor (IR) is mainly expressed

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0135
Volume/Issue:
Volume 22: Issue 5
Free access
J Riedemann Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK

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V M Macaulay Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK

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tyrosine kinase (RTK) that is responsible for mediating IGF bioactivity. The IGF1R gene is located on chromosome 15q26 and encodes a single polypeptide of 1367 amino acids that is constitutively expressed in most cells. The IGF1R and insulin receptor (IR

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01280
Volume/Issue:
Volume 13: Issue Supplement_1
Free access