) in complete media and incubated at 37°C for up to 10 days. The medium was replaced every 3–4 days. Cell migration and invasion assays Cell migration assays were performed using Transwell chambers with a pore size of 8 μm (Corning). For the
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Chi-Yu Kuo, Yuan-Ching Chang, Ming-Nan Chien, Jie-Yang Jhuang, Yi-Chiung Hsu, Shih-Yuan Huang, and Shih-Ping Cheng
Sun Wook Cho, Young A Kim, Hyun Jin Sun, Ye An Kim, Byung-Chul Oh, Ka Hee Yi, Do Joon Park, and Young Joo Park
actions on PTC cell invasiveness and demonstrated bi-directional roles of CXCL16 in macrophage–tumor interactions. Materials and methods Reagents Recombinant human CXCL16, anti-human CXCL16 neutralizing antibody, and human CXCL16 Quantikine ELISA Kit were
Veronica Kalhori, Melissa Magnusson, Muhammad Yasir Asghar, Ilari Pulli, and Kid Törnquist
substantial amount of evidence has implicated S1P in the progression of several types of cancers by enhancing many central events such as proliferation, angiogenesis, migration, and invasion ( Alvarez et al . 2007 , Strub et al . 2010 , Alshaker et al
Xi Wei, Shang Cai, Rebecca J Boohaker, Joshua Fried, Ying Li, Linfei Hu, Yi Pan, Ruifen Cheng, Sheng Zhang, Ye Tian, Ming Gao, and Bo Xu
Introduction Highly aggressive, anaplastic thyroid cancer (ATC) is a rare form of thyroid cancer with median survival of only ~4 months due to invasive nature and metastatic capacity ( Xing 2013 , Molinaro et al . 2017 ). ATC is typically
Lidong Wang, Hao Tan, Yonglian Huang, Mingyue Guo, Yanxu Dong, Chenxi Liu, Huai Zhao, and Zhen Liu
cultured in a medium containing 2% FBS and photographed at 0 and 24 h in the same visual fields under a phase-contrast microscope. The ImageJ software was used to measure and calculate the percentages of wound closure. Matrigel invasion assay
Avaniyapuram Kannan Murugan, Abeer Al-Amr, Mysoon M Al-Ansari, Pulicat S Manogaran, Hindi Al-Hindi, and Ali S Alzahrani
characteristics of thyroid cancer and a high rate of recurrence ( Liu et al. 2013 , 2014 , Xing et al. 2014 ). Yet, some cases with BRAF V600E and without any of the above factors display highly invasive and metastatic phenotypes suggesting that there may
Annu Makker and Madhu Mati Goel
. Atypical endometrial hyperplasia (AEH) has been reported to be associated with invasive EC in 62% endometrial biopsy specimens, suggesting that AEH may be the direct precursor to endometrioid EC (EEC; Amant et al . 2005 , Trimble et al . 2006 ). EEC
Haleh Vosgha, Armin Ariana, Robert Anthony Smith, and Alfred King-yin Lam
promoting angiogenesis have been suggested ( Sang 1998 , Hoeben et al . 2004 , Araujo et al . 2015 ). The interactions of these proteins and their potential roles in the invasive behaviour of anaplastic thyroid carcinoma are yet to be addressed properly
Meenu Jain, Lisa Zhang, Mei He, Ya-Qin Zhang, Min Shen, and Electron Kebebew
. Using siRNA knockdown of TOP2A in ACC cell lines, we found that it regulates cellular proliferation and invasion. Given the consistent overexpression of TOP2A in ACC, we tested 14 TOP2A inhibitors for their antiproliferative effect and found that
Eric Y Lian, Sarah M Maritan, Jessica G Cockburn, Katayoon Kasaian, Mathieu J F Crupi, David Hurlbut, Steven J M Jones, Sam M Wiseman, and Lois M Mulligan
functional differences, the contributions of endogenous RET9 and RET51 isoforms to human thyroid tumourigenesis and to tumour metastasis or invasive spread have not been well characterised. Here, we investigated the roles of total RET and each individual
