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J Cros Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
U1149 – University Paris Diderot, Paris, France

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O Hentic Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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V Rebours U1149 – University Paris Diderot, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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M Zappa Department of Radiology, AP-HP, DHU UNITY, Beaujon Hospital, Clichy, France

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N Gille Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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N Theou-Anton Department of Somatic Genetic, AP-HP, DHU UNITY, Bichat University Hospital, Paris, France

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D Vernerey Methodology and Quality of Life in Oncology Unit (EA 3181), University Hospital of Besançon, Besançon, France

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F Maire Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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P Lévy U1149 – University Paris Diderot, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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P Bedossa Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
U1149 – University Paris Diderot, Paris, France

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V Paradis Department of Pathology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France
U1149 – University Paris Diderot, Paris, France

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P Hammel U1149 – University Paris Diderot, Paris, France
Department of Digestive Oncology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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P Ruszniewski U1149 – University Paris Diderot, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, DHU UNITY, Beaujon University Hospital, Clichy, France

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A Couvelard U1149 – University Paris Diderot, Paris, France
Department of Pathology, AP-HP, DHU UNITY, Bichat University Hospital, Paris, France

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predict the efficacy of TEM in other tumor types ( Hegi et al. 2005 , Schraml et al. 2012 ). There is no consensus on how to best assess MGMT. Methylation of MGMT promoter was associated with a prolonged overall survival in patients with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0117
Volume/Issue:
Volume 23: Issue 8
Free access
Marijn A Vermeulen Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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Carolien H M van Deurzen Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
BOOG Study Center/Dutch Breast Cancer Research Group, Amsterdam, The Netherlands

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Shusma C Doebar Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands

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Wendy W J de Leng Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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John W M Martens BOOG Study Center/Dutch Breast Cancer Research Group, Amsterdam, The Netherlands
Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands

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Paul J van Diest Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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Cathy B Moelans Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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et al. 2010 , Kornegoor et al. 2012 a , b , Lacle et al. 2013 ). Epigenetic changes, including DNA methylation, play an essential role in carcinogenesis besides established players such as mutations, copy number changes and genetic

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Research Article
DOI:
https://doi.org/10.1530/ERC-18-0485
Volume/Issue:
Volume 26: Issue 6
Free access
Kristina Warton Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia

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Kate L Mahon Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia
Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia

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Goli Samimi Garvan Institute of Medical Research, Chris O'Brien Lifehouse, The Kinghorn Cancer Centre and St Vincent's Clinical School, 370 Victoria Street, Darlinghurst, Sydeny, New South Wales, Australia

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treatment. ctDNA can be distinguished from circulating DNA from healthy cells by the presence of genomic aberrations that correspond to those found in the tumor, such as tumor-specific mutations or methylation. The feasibility of using tumor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0369
Volume/Issue:
Volume 23: Issue 3
Open access
Carles Zafon Diabetes and Metabolism Research Unit (VHIR) and Department of Endocrinology, University Hospital Vall d’Hebron and Autonomous University of Barcelona, Barcelona, Spain
Consortium for the Study of Thyroid Cancer (CECaT), Catalonia, Spain

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Joan Gil Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Barcelona, Spain

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Beatriz Pérez-González Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Barcelona, Spain

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Mireia Jordà Consortium for the Study of Thyroid Cancer (CECaT), Catalonia, Spain
Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Barcelona, Spain

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phenotypes. There are several epigenetic mechanisms: DNA methylation, posttranslational modifications of histones, chromatin remodeling or non-coding RNAs. These mechanisms have been reviewed elsewhere ( Bannister & Kouzarides 2011 , Holoch & Moazed 2015

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0093
Volume/Issue:
Volume 26: Issue 7
Free access
Laura M S Seeber
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Ronald P Zweemer
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Luigi Marchionni Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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Leon F A G Massuger Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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Vincent T H B M Smit Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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W Marchien van Baal Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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René H M Verheijen
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Paul J van Diest Department of Gynaecological Oncology, Department of Oncology, Department of Obstetrics and Gynaecology (791), Department of Pathology, Department of Gynaecological Oncology, Department of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands

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Introduction Tumours presumably develop by a stepwise accumulation of interacting epigenetic and genetic events over time ( Baylin & Herman 2000 , Jones & Baylin 2002 ). Promoter methylation is an epigenetic event that plays an important role in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0014
Volume/Issue:
Volume 17: Issue 3
Free access
Charles E Massie Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Inmaculada Spiteri Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Helen Ross-Adams Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley Luxton Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Jonathan Kay Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Hayley C Whitaker Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Mark J Dunning Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Alastair D Lamb Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Antonio Ramos-Montoya Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Daniel S Brewer Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Colin S Cooper Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Rosalind Eeles Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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UK Prostate ICGC Group
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Anne Y Warren Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Simon Tavaré Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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David E Neal Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK
Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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Andy G Lynch Cancer Research UK Cambridge Institute, Division of Genetics and Epidemiology, Department of Biological Sciences and School of Medicine, Royal Marsden NHS Foundation Trust, Departments of Pathology, Urology, Surgical Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

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( Supplementary Figure 1 a). These samples were used for global methylation profiling using Infinium HumanMethylation450 arrays (see below for details). Figure 1 HES5 promoter methylation is an early event in prostate tumourigenesis. (A) Representation of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0454
Volume/Issue:
Volume 22: Issue 2
Open access
I Marinoni Institute of Pathology, University of Bern, Bern, Switzerland

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A Wiederkeher Institute of Pathology, University of Bern, Bern, Switzerland

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T Wiedmer Institute of Pathology, University of Bern, Bern, Switzerland
GCB Graduate School Bern, Bern, Switzerland

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S Pantasis Institute of Pathology, University of Bern, Bern, Switzerland

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A Di Domenico Institute of Pathology, University of Bern, Bern, Switzerland
GCB Graduate School Bern, Bern, Switzerland

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R Frank Institute of Pathology, University of Bern, Bern, Switzerland

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E Vassella Institute of Pathology, University of Bern, Bern, Switzerland

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A Schmitt Institute of Pathology, University of Bern, Bern, Switzerland

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A Perren Institute of Pathology, University of Bern, Bern, Switzerland

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) ). DAXX and ATRX participate in maintaining the epigenetic status of the cells by regulating both DNA methylation and H3.3 deposition at telomeric and peri-centromeric regions. DAXX interacts and recruits DNA methyl-transferase enzyme 1 (DNMT1) to specific

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0554
Volume/Issue:
Volume 24: Issue 3
Free access
Ana Carolina Bueno Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Rui M P da Silva Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Mônica F Stecchini Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Junier Marrero-Gutiérrez Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Danillo C de Almeida e Silva Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Department of Computation and Mathematics, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Izilda Cardinalli Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil

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Carlos Alberto Scrideli Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Thais Junqueira Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil

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Carlos A F Molina Department of Surgery and Anatomy Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Fernando Silva Ramalho Department of Pathology Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Silvio Tucci Jr Department of Surgery and Anatomy Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Fernanda Borchers Coeli-Lacchini Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Ayrton Custodio Moreira Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Leandra N Z Ramalho Department of Pathology Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Silvia Brandalise Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil

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José Andres Yunes Boldrini Children’s Center, State University of Campinas, Campinas, Sao Paulo, Brazil

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Margaret de Castro Department of Internal Medicine Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Ricardo Zorzetto Nicoliello Vêncio Department of Computation and Mathematics, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Sonir R R Antonini Department of Pediatrics Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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have prognostic relevance but once accumulated, represent a complex interplay in patients with unfavorable outcomes ( Pinto et al. 2015 ). Recent genome-wide studies demonstrated the prognostic relevance of ACT methylation profiling. In tumors from

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DOI:
https://doi.org/10.1530/ERC-22-0145
Volume/Issue:
Volume 29: Issue 11
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Takaya Kodama Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Kenji Oki Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Yu Otagaki Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Ryuta Baba Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Akira Okada Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Kiyotaka Itcho Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Kazuhiro Kobuke Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Gaku Nagano Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Haruya Ohno Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Nobuyuki Hinata Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Koji Arihiro Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan

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Celso E Gomez-Sanchez Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, Mississippi, USA
Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA

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Masayasu Yoneda Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Noboru Hattori Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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CTNNB1 mutations is associated with tumorigenesis ( Goh et al. 2014 , Baba et al. 2021 ). Gene transcription is regulated by transcription factors and epigenetic changes in the gene. DNA methylation involves the transfer of a methyl group onto

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DOI:
https://doi.org/10.1530/ERC-22-0115
Volume/Issue:
Volume 29: Issue 8
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S G Creemers Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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P M van Koetsveld Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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F J van Kemenade Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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T G Papathomas Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Histopathology, King’s College Hospital, Denmark Hill, London, UK

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G J H Franssen Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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F Dogan Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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E M W Eekhoff Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

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P van der Valk Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

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W W de Herder Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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J A M J L Janssen Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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R A Feelders Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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L J Hofland Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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( Schmitt et al . 2006 , Wang et al . 2014 ). By the concept of DNA methylation, several factors are supposed to regulate IGF2 expression ( Fig. 1 ). Figure 1 Overview of the imprinted region of the IGF2 gene and H19 gene on the maternal and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0266
Volume/Issue:
Volume 23: Issue 9
Free access