heterozygosity, and short hairpin RNA (shRNA) knockdown of YAP increased migration and invasiveness, and enhanced tumor growth ( Yuan et al . 2008 ). Therefore, the expression and function of YAP in specific cancers requires further investigation. Granulosa cell
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David Fu, Xiangmin Lv, Guohua Hua, Chunbo He, Jixin Dong, Subodh M Lele, David Wan-Cheng Li, Qiongli Zhai, John S Davis, and Cheng Wang
Ssu-Ming Huang, Chingju Lin, Hsiao-Yun Lin, Chien-Ming Chiu, Chia-Wei Fang, Kuan-Fu Liao, Dar-Ren Chen, and Wei-Lan Yeh
prognostic marker in colon cancer. In the present study, we investigated the intracellular signaling pathways involved in the BDNF-regulated cell motility in colon cancer cells. Our results indicated that BDNF induced cell migration by upregulating VEGF
Xianhui Ruan, Xianle Shi, Qiman Dong, Yang Yu, Xiukun Hou, Xinhao Song, Xi Wei, Lingyi Chen, and Ming Gao
signaling pathways in thyroid cancer. Cell apoptosis assay revealed that anlotinib induces apoptosis of thyroid cancer cells, partly through activating the TP53 pathway. Anlotinib also inhibits the migration of thyroid cancer cells, through interfering F
Eric Y Lian, Sarah M Maritan, Jessica G Cockburn, Katayoon Kasaian, Mathieu J F Crupi, David Hurlbut, Steven J M Jones, Sam M Wiseman, and Lois M Mulligan
, RET is not essential for cell survival but promotes changes in cell morphology and transcriptional pattern, and contributes to cell migration and invasion, consistent with a change to a more mesenchymal growth pattern. Interestingly, our data show that
Shuai Dong, Jun Pan, Yi-Bin Shen, Li-Xian Zhu, Liang Chen, Feng Zhu, Hui Li, Hai-Xiang Shen, Qing Xia, Yi-Jun Wu, and Xiao-Jun Xie
migration induced by chemotactic ( Colvin et al. 2010 ). Compared with normal tissues, SYT7 was upregulated in colorectal cancer tissues and its knockout inhibited the proliferation and cloning ability of colorectal cancer cells ( Wang et al. 2018
Janina Ratke, Frank Entschladen, Bernd Niggemann, Kurt S Zänker, and Kerstin Lang
cancer cells, leptin increases proliferation ( Frankenberry et al . 2004 , 2006 , Housa et al . 2006 ). Leptin not only promotes the proliferation, but also the invasion and migration of hepatocellular and endometrial carcinoma cells ( Sharma
Vanessa D'Antongiovanni, Serena Martinelli, Susan Richter, Letizia Canu, Daniele Guasti, Tommaso Mello, Paolo Romagnoli, Karel Pacak, Graeme Eisenhofer, Massimo Mannelli, and Elena Rapizzi
2013 , Klemm & Joyce 2014 ). Single cell and collective migration are hallmarks of cancer invasion and collective migration differs from single cell migration in that the cells remain connected as they move ( Frield & Gilmour 2009 , Wang et al
Chiara Laezza, Simona Pisanti, Anna Maria Malfitano, and Maurizio Bifulco
Marzo 2002 , Portella et al . 2003 ). Moreover, it has been observed that cannabinoid receptors activation is able to inhibit vascular endothelial cell migration and to downregulate the expression and the activity of matrix metalloproteinase-2, a
Jesús Morillo-Bernal, Lara P Fernández, and Pilar Santisteban
thyroid development is required for thyrocyte precursor migration ( De Felice et al. 1998 , De Felice & Di Lauro 2004 , Parlato et al. 2004 , Fernandez et al. 2015 ). In the differentiated thyroid, Foxe1 is a transcriptional activator of the
Muhammad Yasir Asghar, Tero Viitanen, Kati Kemppainen, and Kid Törnquist
al . 2011 ). Currently, there is no effective treatment available ( Smallridge et al . 2009 ). Sphingosine 1-phosphate (S1P) is a bioactive lipid regulating many cellular processes, including cell migration and proliferation. S1P may enhance or
