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Seog Yun Park Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Yuh-S Jung Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Chang Hwan Ryu Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Chang Yoon Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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You Jin Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Eun Kyung Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Seok-Ki Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Tae Sung Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Tae Hyun Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jeyun Jang Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Daeyoon Park Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Seung Myung Dong Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jae-Goo Kang Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jin Soo Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Junsun Ryu Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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tumors remain undetected. Furthermore, the ability to detect small malignancies is markedly reduced when diffuse thyroid disease is also present ( Park et al . 2013 ). Therefore, the possibility of multifocal disease in patients for whom only a single

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0152
Volume/Issue:
Volume 22: Issue 4
Free access
M Capezzone
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S Marchisotta
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S Cantara
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G Busonero
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L Brilli
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K Pazaitou-Panayiotou Section of Endocrinology and Metabolism, Department of Endocrinology-Endocrine Oncology, Section of Endocrine Surgery, Unit of Otorinolaringoiatry, Department of Human Pathology and Oncology, Biology Section, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy

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A F Carli Section of Endocrinology and Metabolism, Department of Endocrinology-Endocrine Oncology, Section of Endocrine Surgery, Unit of Otorinolaringoiatry, Department of Human Pathology and Oncology, Biology Section, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy

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G Caruso Section of Endocrinology and Metabolism, Department of Endocrinology-Endocrine Oncology, Section of Endocrine Surgery, Unit of Otorinolaringoiatry, Department of Human Pathology and Oncology, Biology Section, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy

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P Toti Section of Endocrinology and Metabolism, Department of Endocrinology-Endocrine Oncology, Section of Endocrine Surgery, Unit of Otorinolaringoiatry, Department of Human Pathology and Oncology, Biology Section, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy

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S Capitani Section of Endocrinology and Metabolism, Department of Endocrinology-Endocrine Oncology, Section of Endocrine Surgery, Unit of Otorinolaringoiatry, Department of Human Pathology and Oncology, Biology Section, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy

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A Pammolli Section of Endocrinology and Metabolism, Department of Endocrinology-Endocrine Oncology, Section of Endocrine Surgery, Unit of Otorinolaringoiatry, Department of Human Pathology and Oncology, Biology Section, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy

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F Pacini
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NMTCs, FNMTCs are more frequently multifocal, have higher rate of relapse, and are diagnosed at younger ages. In this study, we demonstrate that in a series of NMTC including patients with FNMTC, the latter exhibit more aggressive tumor phenotype. In

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0080
Volume/Issue:
Volume 15: Issue 4
Free access
Nicoletta Biglia Academic Department of Gynaecological Oncology, Mauriziano Umberto I° Hospital of Turin and Institute for Cancer Research and Treatment of Candiolo, University of Turin, Largo Turati 62, 10129 Turin, Italy

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Luca Mariani Academic Department of Gynaecological Oncology, Mauriziano Umberto I° Hospital of Turin and Institute for Cancer Research and Treatment of Candiolo, University of Turin, Largo Turati 62, 10129 Turin, Italy

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Luca Sgro Academic Department of Gynaecological Oncology, Mauriziano Umberto I° Hospital of Turin and Institute for Cancer Research and Treatment of Candiolo, University of Turin, Largo Turati 62, 10129 Turin, Italy

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Paola Mininanni Academic Department of Gynaecological Oncology, Mauriziano Umberto I° Hospital of Turin and Institute for Cancer Research and Treatment of Candiolo, University of Turin, Largo Turati 62, 10129 Turin, Italy

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Giulia Moggio Academic Department of Gynaecological Oncology, Mauriziano Umberto I° Hospital of Turin and Institute for Cancer Research and Treatment of Candiolo, University of Turin, Largo Turati 62, 10129 Turin, Italy

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Piero Sismondi Academic Department of Gynaecological Oncology, Mauriziano Umberto I° Hospital of Turin and Institute for Cancer Research and Treatment of Candiolo, University of Turin, Largo Turati 62, 10129 Turin, Italy

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resonance imaging Further diagnostic difficulties may derive from the higher rates of multifocal and/or multicentric tumours when compared with ductal carcinoma and the associated higher incidence of synchronous and/or metachronous controlateral

Article Type:
Review Article
DOI:
https://doi.org/10.1677/ERC-06-0060
Volume/Issue:
Volume 14: Issue 3
Free access
Zoran Erlic
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Ursula Ploeckinger Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Alberto Cascon Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany
Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Michael M Hoffmann Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Laura von Duecker
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Aurelia Winter
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Gerit Kammel
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Janina Bacher
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Maren Sullivan
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Berend Isermann Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Lars Fischer Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Andreas Raffel Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Wolfram Trudo Knoefel Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Matthias Schott Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Tobias Baumann Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Oliver Schaefer Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Tobias Keck Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Richard P Baum Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Ioana Milos Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Mihaela Muresan Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Mariola Peczkowska Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Andrzej Januszewicz Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Kenko Cupisti Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Anke Tönjes Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Mathias Fasshauer Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Jan Langrehr Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Peter von Wussow Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Abbas Agaimy Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Günter Schlimok Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Regina Lamberts Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Thorsten Wiech Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Kurt Werner Schmid Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Alexander Weber
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Mercedes Nunez
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Mercedes Robledo Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany
Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Charis Eng Section of Preventive Medicine, Department of Hepatology and Gastroenterology, Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Laboratory Medicine, Internal Medicine I and Clinical Chemistry, Surgery, General and Visceral Surgery, Endocrinology, Diagnostic Radiology, Visceral Surgery, Department of Nuclear Medicine/Center for PET, Department of Endocrinology of the University of Medicine and Pharmacy Victor Babes, Department of Endocrinology, Institute of Cardiology, Medical Clinic 3, Department of Surgery, Private Practice, Department of Pathology, Medical Clinic 2, Klinikum Peine gGmbH, Institute of Pathology, Institute of Pathology and Neuropathology, Genomic Medicine Institute, Department of Nephrology, Albert-Ludwigs-University, Hugstetter Strasse 55, D-79106 Freiburg, Germany

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Hartmut P H Neumann
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for the VHL-ICT Consortium and the German NET Registry
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the VHL group and 57 ( s.d. 12.0) years for the sporadic group (<0.001). Patients with VHL-associated ICTs were more frequently female (VHL 34/54 vs sporadic 37/92, P =0.01), had more multifocal ICTs (VHL 13/54 vs sporadic 5/92; P =0.0029), and had

Article Type:
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DOI:
https://doi.org/10.1677/ERC-10-0037
Volume/Issue:
Volume 17: Issue 4
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Seo Ki Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

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Jung-Woo Woo Department of Surgery, Changwon Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Changwon, South Korea

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Jun Ho Lee Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea

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Inhye Park Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

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Jung-Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

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to follow-up within 6 months). Surgical strategy TT was performed when the primary tumor size was >1cm, and when multifocality, bilaterality, ETE, or regional LN metastasis was detected during preoperative or intraoperative examination

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DOI:
https://doi.org/10.1530/ERC-15-0572
Volume/Issue:
Volume 23: Issue 5
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Fei Li Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Guangqi Chen Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Chunjun Sheng Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Aaron M Gusdon Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Yueye Huang Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Zhongwei Lv Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Huixiong Xu Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Mingzhao Xing Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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Shen Qu Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China
Department of Endocrinology, First Clinical Medical College, Jiangsu Institute of Nuclear Medicine, Department of Cardiology, Department of Neurology and Neuroscience, Departments of Nuclear Medicine, Ultrasound Medicine, Thyroid Institute, Division of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Middle Road, Shanghai 200072, China

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from many studies have indicated that BRAFV600E mutation is significantly associated with aggressive clinicopathological features of PTC, such as multifocality, extrathyroid extension, lymph node metastases (LNMs) at presentation, and advanced stage

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DOI:
https://doi.org/10.1530/ERC-14-0531
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Volume 22: Issue 2
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N Garcia de la Torre
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I Buley
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J A H Wass
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H E Turner
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thyroid tissue; and (3) to assess whether MVD, LVD and expression of these angiogenic and lymphangiogenic factors correlates with aspects of tumour behaviour (tumour size, multifocality, lymph nodes metastases at thyroid-ectomy and distant metastases at

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https://doi.org/10.1677/erc.1.01210
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Volume 13: Issue 3
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Umasuthan Srirangalingam
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Bernard Khoo
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Lisa Walker Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Fiona MacDonald Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Robert H Skelly Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Emad George Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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David Spooner Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Linda B Johnston
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John P Monson
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Ashley B Grossman
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W M Drake
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Scott A Akker
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Patrick J Pollard Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Nick Plowman Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Norbert Avril Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Daniel M Berney Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Jacky M Burrin Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Rodney H Reznek Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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V K Ajith Kumar Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Eamonn R Maher Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

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Shern L Chew
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with respect to location of disease, size of tumours, multifocality and metastatic potential of disease. We also note differences with respect to associated symptoms and catecholamine secretion. Materials and Methods Subjects for this study were

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DOI:
https://doi.org/10.1677/ERC-08-0239
Volume/Issue:
Volume 16: Issue 2
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Thalles Fernando Rocha Ruiz Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil

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Simone J Colleta Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil

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Ellen C R Leonel Department of Histology, Embryology and Cell Biology, Institute of Biological Sciences (ICB III), Federal University of Goiás (UFG), Campus Samambaia, Goiânia, Goiás, Brazil

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Sebastião Roberto Taboga Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil

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cells and alveolar shape, with the development of multifocal carcinoma regions. These regions showed heterogeneous nuclear atypia ( Fig. 2H ), with no apparent cytokeratin expression ( Fig. 2I ) and enhanced vimentin expression ( Fig. 2J ). Figure 2

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DOI:
https://doi.org/10.1530/ERC-21-0198
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Volume 28: Issue 11
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Brian Hung-Hin Lang Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China

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Young Jun Chai Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China

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Benjamin J Cowling Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China

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Hye Sook Min Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China

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Kyu Eun Lee Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China

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Yeo-Kyu Youn Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China
Department of Surgery, Department of Surgery, School of Public Health, Department of Pathology, Cancer Research Institute, The University of Hong Kong, Hong Kong SAR, China

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, multifocality, tumor size, and extrathyroidal extension, BRAF became nonsignificant. Therefore, currently there is still insufficient data to support pCND on the basis of BRAF mutation status alone in low-risk PTC ( Xing et al . 2013 a ). Given these

Article Type:
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DOI:
https://doi.org/10.1530/ERC-13-0291
Volume/Issue:
Volume 21: Issue 2
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