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C R C Pieterman
C R C Pieterman
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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E B Conemans
E B Conemans
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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K M A Dreijerink
K M A Dreijerink
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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J M de Laat
J M de Laat
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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H Th M Timmers
H Th M Timmers
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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M R Vriens
M R Vriens
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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G D Valk
G D Valk
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
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Introduction Thoracic and duodenopancreatic neuroendocrine tumors (dpNETs) can occur either sporadically or as a manifestation of an inherited syndrome, most importantly the multiple endocrine neoplasia type 1 (MEN1) syndrome. This is an autosomal
A A Pannett
A A Pannett
Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
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R V Thakker
R V Thakker
Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
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Combined clinical and laboratory investigations of multiple endocrine neoplasia type 1 (MEN1) have resulted in an increased understanding of this disorder which may be inherited as an autosomal dominant condition. Defining the features of each disease manifestation in MEN1 has improved patient management and treatment, and has also facilitated a screening protocol to be instituted. The application of the techniques of molecular biology has enabled the identification of the gene causing MEN1 and the detection of mutations in patients. The function of the protein encoded by the MEN1 gene has been shown to be in the regulation of JunD-mediated transcription but much still remains to be elucidated. However, these recent advances provide for the identification of mutant MEN1 gene carriers who are at a high risk of developing this disorder and thus require regular and biochemical screening to detect the development of endocrine tumours.
Xiao-Hua Jiang
Xiao-Hua Jiang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Jie-Li Lu
Jie-Li Lu
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Bin Cui
Bin Cui
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Yong-Ju Zhao
Yong-Ju Zhao
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Wei-qing Wang
Wei-qing Wang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Jian-Min Liu
Jian-Min Liu
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Wen-Qiang Fang
Wen-Qiang Fang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Ya-Nan Cao
Ya-Nan Cao
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Yan Ge
Yan Ge
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Chang-xian Zhang
Chang-xian Zhang
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Huguette Casse
Huguette Casse
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Xiao-Ying Li
Xiao-Ying Li
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Guang Ning
Guang Ning
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Shanghai Clinical Center for Endocrine and Metabolic Diseases,, Laboratory for Endocrine and Metabolic Diseases,, Department of Radiological Medicine,, Laboratoire Genetique et Cancer,, Shanghai Key Laboratory for Endocrine Tumours,, Shanghai Institute of Endocrinology and Metabolism and Chinese-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited disorder characterized by frequent occurrence of tumours of parathyroid, pancreatic islet and anterior pituitary, sometimes in combination with other rare
P H Kann
P H Kann
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E Balakina
E Balakina
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D Ivan
D Ivan
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D K Bartsch
D K Bartsch
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S Meyer
S Meyer
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K-J Klose
K-J Klose
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Th Behr
Th Behr
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P Langer
P Langer
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T, Celik I, Rothmund M & Nies C 2000 Pancreaticoduodenal endocrine tumors in multiple endocrine neoplasia type 1: surgery or surveillance? Surgery 128 958 –966. Bolondi L , Li Bassi S, Gaiani S, Campione O, Marrano
Brian Harding
Brian Harding
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Manuel C Lemos
Manuel C Lemos
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Anita A C Reed
Anita A C Reed
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Gerard V Walls
Gerard V Walls
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Jeshmi Jeyabalan
Jeshmi Jeyabalan
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Michael R Bowl
Michael R Bowl
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Hilda Tateossian
Hilda Tateossian
Academic Endocrine Unit, Mammalian Genetics Unit and Mary Lyon Centre, Department of Neuropathology, Unit of Clinical Biochemistry, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK
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Nicky Sullivan
Nicky Sullivan
Academic Endocrine Unit, Mammalian Genetics Unit and Mary Lyon Centre, Department of Neuropathology, Unit of Clinical Biochemistry, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK
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Tertius Hough
Tertius Hough
Academic Endocrine Unit, Mammalian Genetics Unit and Mary Lyon Centre, Department of Neuropathology, Unit of Clinical Biochemistry, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK
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William D Fraser
William D Fraser
Academic Endocrine Unit, Mammalian Genetics Unit and Mary Lyon Centre, Department of Neuropathology, Unit of Clinical Biochemistry, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK
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Olaf Ansorge
Olaf Ansorge
Academic Endocrine Unit, Mammalian Genetics Unit and Mary Lyon Centre, Department of Neuropathology, Unit of Clinical Biochemistry, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK
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Michael T Cheeseman
Michael T Cheeseman
Academic Endocrine Unit, Mammalian Genetics Unit and Mary Lyon Centre, Department of Neuropathology, Unit of Clinical Biochemistry, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Headington, Oxford OX3 7LJ, UK
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Rajesh V Thakker
Rajesh V Thakker
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Introduction Multiple endocrine neoplasia type 1 (MEN1), in man, is characterised by the combined occurrence of tumours of parathyroids, pancreatic islets and anterior pituitary ( Marx 2005 , Thakker 2006 ). Some patients may also develop adrenal
Nader Hussein
Nader Hussein
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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JieLi Lu
JieLi Lu
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Huguette Casse
Huguette Casse
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Sandra Fontanière
Sandra Fontanière
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Anne-Marie Morera
Anne-Marie Morera
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Séverine Mazaud Guittot
Séverine Mazaud Guittot
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Alain Calender
Alain Calender
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Nathalie Di Clemente
Nathalie Di Clemente
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Chang X Zhang
Chang X Zhang
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
Université Claude Bernard Lyon, CNRS UMR5201, INSERM-INRA U418, INSERM, Groupe d'Etude Recherche, Lyon, France; Faculté de Médecine, Université Lyon 1, Lyon F-69003, France; Laboratoire Génétique Moléculaire, Signalisation et Cancer, 8 Avenue Rockefeller, Lyon F-69373, France
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Introduction The patients with multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome transmitted with an autosomal dominant trait, predispose to the occurrence of multiple endocrine tumours of the parathyroids, pancreas, anterior
Jerena Manoharan
Jerena Manoharan
Department of Visceral Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany
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Max B Albers
Max B Albers
Department of Visceral Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany
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Detlef K Bartsch
Detlef K Bartsch
Department of Visceral Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany
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of Ga-68-DOTATOC-PET-CT in routine screening of patients with multiple endocrine neoplasia Type 1 . World Journal of Surgery 41 1521 – 1527 . ( doi:10.1007/s00268-017-3907-9 ) Anlauf M Garbrecht N Henopp T Schmitt A Schlenger
Uriel Clemente-Gutierrez
Uriel Clemente-Gutierrez
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Carolina R C Pieterman
Carolina R C Pieterman
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Michael S Lui
Michael S Lui
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Thomas Szabo Yamashita
Thomas Szabo Yamashita
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Andrés Tame-Elorduy
Andrés Tame-Elorduy
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Bernice L Huang
Bernice L Huang
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Aditya S Shirali
Aditya S Shirali
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Derek J Erstad
Derek J Erstad
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Jeffrey E Lee
Jeffrey E Lee
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Sarah B Fisher
Sarah B Fisher
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Paul H Graham
Paul H Graham
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Elizabeth G Grubbs
Elizabeth G Grubbs
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Steven G Waguespack
Steven G Waguespack
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Chaan S Ng
Chaan S Ng
Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Nancy Perrier
Nancy Perrier
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is a rare, genetically inherited disease classically characterized by the development of parathyroid hyperplasia, neuroendocrine tumors in the pancreas and duodenum, and pituitary
Kreepa G Kooblall
Kreepa G Kooblall
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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Victoria J Stokes
Victoria J Stokes
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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Omair A Shariq
Omair A Shariq
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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Katherine A English
Katherine A English
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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Mark Stevenson
Mark Stevenson
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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John Broxholme
John Broxholme
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
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Benjamin Wright
Benjamin Wright
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
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Helen E Lockstone
Helen E Lockstone
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
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David Buck
David Buck
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
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Simona Grozinsky-Glasberg
Simona Grozinsky-Glasberg
Neuroendocrine Tumor Unit, ENETS Center of Excellence, Endocrinology & Metabolism Department, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Israel
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Christopher J Yates
Christopher J Yates
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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Rajesh V Thakker
Rajesh V Thakker
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK
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Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK
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Kate E Lines
Kate E Lines
OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid tumours and neuroendocrine tumours (NETs) of the pancreas and pituitary. Over 90% of patients
Elizabeth Grubbs
Elizabeth Grubbs
Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas
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Daniel Halperin
Daniel Halperin
Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas
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Steven G Waguespack
Steven G Waguespack
Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas
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Robert F Gagel
Robert F Gagel
Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas
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Overview The multiple endocrine neoplasia syndromes are a varied group of disorders that include multiple endocrine neoplasia types 1 and 2 (MEN 1, MEN 2), von Hippel-Lindau (VHL) disease , Carney complex (CC), hereditary pheochromocytoma
