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Krystallenia I Alexandraki Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Gregory A Kaltsas Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Simona Grozinsky-Glasberg Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Eleftherios Chatzellis Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Ashley B Grossman Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Introduction Neuroendocrine neoplasms (NENs), previously named ‘carcinoid’ tumours, most frequently occur in the gastrointestinal (GI) tract (54.5%) and have been an area of ongoing interest in the field of many different disciplines including

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0310
Volume/Issue:
Volume 23: Issue 1
Free access
Günter Klöppel Department of Pathology, Technical University of München, Ismaninger Strasse 22, 81675 München, Germany

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Introduction Endocrine neoplasms can be divided according to the chemical nature of their secretion products into two groups. Neoplasms that produce and secrete (glyco)peptide hormones and biogenic amines comprise the first group. The second group

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0013
Volume/Issue:
Volume 18: Issue S1
Free access
Guido Rindi Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Università Cattolica del Sacro Cuore, Rome, Italy
ENETS Center of Excellence, Neuroendocrine Tumour (NET) Center, Rome, Italy

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Frediano Inzani Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
ENETS Center of Excellence, Neuroendocrine Tumour (NET) Center, Rome, Italy

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types or, perhaps, neuroendocrine-committed cells do transform, generating neoplasms. Neoplasms made by cells with a neuroendocrine phenotype are today defined as neuroendocrine neoplasia (NEN). Similar to neuroendocrine cells, NEN are observed in pure

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0036
Volume/Issue:
Volume 27: Issue 6
Free access
Yulong Li Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases

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William F Simonds National Institutes of Health, Bethesda, Maryland, USA

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different treatment approaches. Being familiar with their unique features and natural history may facilitate diagnosis and help to establish individua­lized management to improve outcomes. We herein summarize and update the knowledge on endocrine neoplasms

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0059
Volume/Issue:
Volume 23: Issue 6
Free access
Fritz-Line Vélayoudom-Céphise Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Pierre Duvillard Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Lydia Foucan Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Julien Hadoux Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Cecile N Chougnet Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Sophie Leboulleux Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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David Malka Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Joël Guigay Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Diane Goere Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Thierry Debaere Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Caroline Caramella Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Martin Schlumberger Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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David Planchard Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Dominique Elias Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Michel Ducreux Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Jean-Yves Scoazec Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Eric Baudin Departments of Nuclear Medicine and Endocrine Oncology, Pathology, Department of Biostatistics and Epidemiology, Departments of Gastroenterology, Thoracic Oncology, Digestive Surgery, Medical Imaging, Faculté de Médecine Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France

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Introduction Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are rare tumors defined by the expression of specific diagnostic biomarkers ( Baudin 2007 , Modlin et al . 2008 , Yao et al . 2008 ). Their prognosis is best characterized by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0027
Volume/Issue:
Volume 20: Issue 5
Free access
Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Sciences, University of Bergen, Bergen, Norway

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Grace Kong Department of Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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-term toxicity. 177 Lu-DOTA-octreotate (LuTathera) has recently obtained regulatory approval for patients with progressive metastatic grade 1–2 GEP NET. High-grade gastroenteropancreatic neuroendocrine neoplasms: NET G3 and NEC Gastroenteropancreatic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0400
Volume/Issue:
Volume 27: Issue 3
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Rachel Pimenta Riechelmann Clinical Oncology Department, A.C. Camargo Cancer Center, São Paulo, Brazil

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Mauro Daniel Spina Donadio Clinical Oncology Department, A.C. Camargo Cancer Center, São Paulo, Brazil

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Victor Hugo Fonseca de Jesus Clinical Oncology Department, A.C. Camargo Cancer Center, São Paulo, Brazil

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Nathalia de Angelis de Carvalho Clinical and Functional Genomics Group, International Research Center/CIPE, A.C. Camargo Cancer Center, São Paulo, Brazil

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Karina Miranda Santiago Clinical and Functional Genomics Group, International Research Center/CIPE, A.C. Camargo Cancer Center, São Paulo, Brazil

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Milton J Barros Clinical Oncology Department, A.C. Camargo Cancer Center, São Paulo, Brazil

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Laura Lopes Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil

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Gabriel Oliveira dos Santos Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil

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Maria Nirvana Formiga Clinical Oncology Department, A.C. Camargo Cancer Center, São Paulo, Brazil
Department of Oncogenetics, A.C. Camargo Cancer Center, São Paulo, Brazil

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Dirce Maria Carraro Clinical and Functional Genomics Group, International Research Center/CIPE, A.C. Camargo Cancer Center, São Paulo, Brazil
National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation (INCITO-INOTE), São Paulo, Brazil

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Giovana Tardin Torrezan Clinical and Functional Genomics Group, International Research Center/CIPE, A.C. Camargo Cancer Center, São Paulo, Brazil
National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation (INCITO-INOTE), São Paulo, Brazil

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Introduction Neuroendocrine neoplasms (NENs), including well-differentiated neuroendocrine tumours (NETs) and poorly differentiated neuroendocrine carcinomas (NECs), comprise an infrequent group of cancers with heterogeneous behaviour and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0258
Volume/Issue:
Volume 30: Issue 6
Restricted access
Pedro Weslley Rosario Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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Maurício Buzelin Nunes Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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Marcelo Saldanha Nunes Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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Maria Regina Calsolari Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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Introduction Recently, it was proposed that some papillary thyroid carcinomas (PTC) will no longer be termed ‘cancer’ and instead be called ‘noninvasive follicular thyroid neoplasm with papillary-like nuclear features’ (NIFTP) ( Nikiforov et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0379
Volume/Issue:
Volume 23: Issue 12
Free access
Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK
NHS Nightingale Hospital London, London, UK

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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Introduction Neuroendocrine neoplasms (NEN) represent a heterogeneous class of tumours that arise from nigh ubiquitously dispersed neuroendocrine cells, which may be stratified into clinically meaningful sub-groups on the basis of their

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0074
Volume/Issue:
Volume 27: Issue 9
Free access
Lisa Bodei Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
LuGenIum Consortium for Independent Research, Milan, Rotterdam, Bad Berka, London

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Irvin M Modlin LuGenIum Consortium for Independent Research, Milan, Rotterdam, Bad Berka, London
Emeritus Professor Gastroenterological Surgery, Yale University, School of Medicine, New Haven, Connecticut, USA

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Flavio Forrer Nuclear Medicine, Cantonal Hospital, St. Gallen, Switzerland

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Marta Cremonesi Division of Health Physics, European Institute of Oncology, Milan, Italy

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Rodney J Hicks Centre for Cancer Imaging, The Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Australia

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Samer Ezziddin Department of Nuclear Medicine, Saarland University Hospital, Homburg, Saarland, Germany

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Arturo Chiti Humanitas University, Milan, Italy

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therapy-related myeloid neoplasms (t-MNs) 30–70months after PRRT at the Erasmus Medical Center (EMC) Rotterdam. Compared to the rest of the cohort who also received PRRT, these 20 patients had more cycles of chemotherapy, more cycles of alkylating agents

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-16-0258
Volume/Issue:
Volume 23: Issue 8
Free access