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Wouter T Zandee, Kimberly Kamp, Roxanne C van Adrichem, Richard A Feelders and Wouter W de Herder

Introduction Neuroendocrine tumor (NETs) are often best known for causing hypersecretory syndromes, through the hormones they secrete, which is mainly determined by the cell of origin ( Kaltsas et al . 2004 ). More than 15 individual

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Elke Tatjana Aristizabal Prada, Vera Heinzle, Thomas Knösel, Svenja Nölting, Gerald Spöttl, Julian Maurer, Christine Spitzweg, Martin Angele, Nina Schmidt, Felix Beuschlein, Günter K Stalla, Rainer Blaser, Klaus A Kuhn and Christoph J Auernhammer

Introduction Neuroendocrine tumors (NETs) are highly heterogeneous tumors originating from distinct cell precursors ( Schimmack et al . 2011 ). Current data show an increase in incidence of gastroenteropancreatic neuroendocrine tumors (GEP

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Taymeyah Al-Toubah, Stefano Partelli, Mauro Cives, Valentina Andreasi, Franco Silvestris, Massimo Falconi, Daniel A Anaya and Jonathan Strosberg

Introduction Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors which include NETs of the gastrointestinal tract and pancreas. Tumor grade and differentiation are important prognostic factors. Low

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Georg Hilfenhaus, Andreas Göhrig, Ulrich-Frank Pape, Tabea Neumann, Henning Jann, Dietmar Zdunek, Georg Hess, Jean Marie Stassen, Bertram Wiedenmann, Katharina Detjen, Marianne Pavel and Christian Fischer

Introduction Neuroendocrine tumors (NETs) are rare neoplasms with an estimated annual incidence of 2–5/100 000, and are typically diagnosed at an advanced/metastatic stage of the disease. Despite dissemination however, the clinical course is

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Kimberly Kamp, Brenda Gumz, Richard A Feelders, Dik J Kwekkeboom, Gregory Kaltsas, Frederico P Costa and Wouter W de Herder

Introduction Neuroendocrine tumors (NETs) form a heterogeneous group of relatively rare neoplasms that originate from different types of neuroendocrine cells ( Modlin et al . 2008 ). The incidence and prevalence of gastroenteropancreatic NETs (GEP

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Deborah W Neklason, James VanDerslice, Karen Curtin and Lisa A Cannon-Albright

Introduction Carcinoids are rare neuroendocrine tumors; 67% occur in the gastrointestinal tract, primarily in the small intestine ( Modlin et al . 2003 , Yao et al . 2008 ). Carcinoid tumors of the small intestine, presently called small

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Aristides Lytras and George Tolis

Introduction Multiple neuroendocrine tumor syndromes may appear in a sporadic mode. The McCune–Albright syndrome (MAS; OMIM #174 800), a sporadic disease, representing a mosaic case of GNAS gene mutation leading to stimulatory G-protein α subunit (G

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Nicole Panarelli, Kathrin Tyryshkin, Justin Jong Mun Wong, Adrianna Majewski, Xiaojing Yang, Theresa Scognamiglio, Michelle Kang Kim, Kimberly Bogardus, Thomas Tuschl, Yao-Tseng Chen and Neil Renwick

Introduction Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are increasingly common and clinically diverse neoplasms ( Yao et al . 2008 , Lawrence et al . 2011 ) that are challenging to evaluate histologically ( Klimstra 2016

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Matthew H Kulke

Introduction Neuroendocrine tumors comprise a diverse group of malignancies and, when defined broadly, include not only gastrointestinal neuroendocrine tumors but also pheochromocytoma, thyroid cancer, and even small cell lung

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Matthias Beyens, Timon Vandamme, Marc Peeters, Guy Van Camp and Ken Op de Beeck

regulating cell growth, proliferation, survival and protein synthesis in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) ( Missiaglia et al. 2010 , Jiao et al. 2011 , Kasajima et al. 2011 ). GEP-NETs include small intestinal NETs (siNETs) and