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Sarah B Bateni Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
University of Alabama at Birmingham, Department of Surgery, Division of Surgical Oncology, Birmingham, Alabama, USA

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Natalie G Coburn Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Calvin Law Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Simron Singh Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Sten Myrehaug Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Angela Assal Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Julie Hallet Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Introduction Neuroendocrine tumors (NETs) are rare tumors originating from the neuroendocrine system along the gastrointestinal tract and lungs ( Yao et al. 2008 , Hallet et al. 2015 , Dasari et al. 2017 , 2018 ). Although

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0337
Volume/Issue:
Volume 30: Issue 8
Restricted access
Germano Gaudenzi Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche di Neuroendocrinologia Geriatrica ed Oncologica, Milan, Italy

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Silvia Carra Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche Endocrino-Metaboliche, Milan, Italy

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Alessandra Dicitore Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Maria Celeste Cantone Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Luca Persani Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche Endocrino-Metaboliche, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Giovanni Vitale Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche di Neuroendocrinologia Geriatrica ed Oncologica, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Introduction Neuroendocrine tumors (NETs) represent a broad class of neoplasms originating from neuroendocrine cells. NETs can cause a wide array of symptoms depending on the type of tumor, its location and the production of several factors

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0437
Volume/Issue:
Volume 27: Issue 6
Free access
Jaydira Del Rivero Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA

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Josh Mailman NorCal CarciNET Community, Oakland, California, USA

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Michael W Rabow Department of Internal Medicine, Division of Palliative Medicine, University of California, San Francisco, San Francisco, California, USA

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Jennifer A Chan Harvard Medical School, Program in Carcinoid and Neuroendocrine Tumors, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Sarah Creed Good Shepherd Community Care, Harvard Kennedy School, Natick, Massachusetts, USA

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Hagen F Kennecke Providence Cancer Institute Franz Clinic, Portland Providence Medical Center, Portland, Oregon, USA

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Janice Pasieka Department of Surgery, Section of General Surgery, University of Calgary, Cumming School of Medicine, Calgary, Canada

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Jennifer Zuar Department of Internal Medicine, Division of Geriatrics and Palliative Medicine, Alpert Medical School, Providence, Rhode Island, USA

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Simron Singh Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Lauren Fishbein Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA

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lung cancer ( Temel et al. 2010 , Ferrell et al. 2017 ). Patients with neuroendocrine tumors (NETs) represent a unique population, as many have metastatic disease at presentation, yet can have prolonged survival rates for years. Since these

Article Type:
Other
DOI:
https://doi.org/10.1530/ERC-22-0226
Volume/Issue:
Volume 30: Issue 7
Open access
Nicole Panarelli Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Kathrin Tyryshkin Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Justin Jong Mun Wong Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Adrianna Majewski Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Xiaojing Yang Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Theresa Scognamiglio Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Michelle Kang Kim Center for Carcinoid and Neuroendocrine Tumors of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Kimberly Bogardus HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Thomas Tuschl HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Yao-Tseng Chen Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Neil Renwick Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Introduction Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are increasingly common and clinically diverse neoplasms ( Yao et al . 2008 , Lawrence et al . 2011 ) that are challenging to evaluate histologically ( Klimstra 2016

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0244
Volume/Issue:
Volume 26: Issue 1
Free access
Thomas Cuny Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), Marseille, France
Department of Endocrinology, Assistance Publique – Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, Centre de Référence des Maladies Rares Hypophysaires HYPO, Marseille, France

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Wouter de Herder Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Anne Barlier Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), Marseille, France
Department of Endocrinology, Assistance Publique – Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, Centre de Référence des Maladies Rares Hypophysaires HYPO, Marseille, France

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Leo J Hofland Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Introduction Human gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogeneous group of tumors emerging from cells producing glycopeptides and biogenic amines ( Klöppel 2011 ). They account for approximately 0.5% of all

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0025
Volume/Issue:
Volume 25: Issue 11
Free access
Matthias Beyens Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
Center for Oncological Research, University of Antwerp, Antwerp, Belgium

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Timon Vandamme Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
Center for Oncological Research, University of Antwerp, Antwerp, Belgium
Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

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Marc Peeters Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium

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Guy Van Camp Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
Center for Oncological Research, University of Antwerp, Antwerp, Belgium

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Ken Op de Beeck Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
Center for Oncological Research, University of Antwerp, Antwerp, Belgium

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regulating cell growth, proliferation, survival and protein synthesis in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) ( Missiaglia et al. 2010 , Jiao et al. 2011 , Kasajima et al. 2011 ). GEP-NETs include small intestinal NETs (siNETs) and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0420
Volume/Issue:
Volume 26: Issue 3
Free access
Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Alessandra Dicitore Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Concetta Sciammarella Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Sergio Di Molfetta Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy

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Manila Rubino Unit of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, Milan, Italy

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Antongiulio Faggiano Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Introduction Neuroendocrine tumors (NETs) comprise a heterogeneous group of neoplasms in most cases with a low rate of growth and sometimes able to produce and secrete several hormones that drive forward specific clinical syndromes, leading to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0010
Volume/Issue:
Volume 25: Issue 6
Free access
Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Germano Gaudenzi Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Alessandra Dicitore Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Franco Cotelli Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Diego Ferone Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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Luca Persani Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Biosciences, Endocrinology Unit, University of Milan, Milan, Italy

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a model in cancer research, focusing on potential applications in neuroendocrine tumors (NETs). Zebrafish as a cancer model Although fish do not have certain organs found in mammals (breast, prostate, and lung), zebrafish spontaneously develops

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0388
Volume/Issue:
Volume 21: Issue 1
Free access
Nitya Raj Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Youyun Zheng Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Haley Hauser Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Joanne Chou Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Johnathan Rafailov Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jad Bou-Ayache Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Peter Sawan Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jamie Chaft Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jennifer Chan Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Kimberly Perez Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Charles Rudin Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Laura Tang Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Diane Reidy-Lagunes Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Introduction Well-differentiated neuroendocrine tumors (WDNETs) arising from varying anatomic sites are biologically different, with the tumor embryologic origin (foregut, midgut, hindgut) important for disease classification and to stratify

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0446
Volume/Issue:
Volume 28: Issue 4
Restricted access
J R Strosberg
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J A Chan Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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D P Ryan Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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J A Meyerhardt Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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C S Fuchs Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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T Abrams Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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E Regan Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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R Brady Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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J Weber
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T Campos
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L K Kvols
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M H Kulke Department of GI Oncology, Department of Medical Oncology, Division of Medical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA

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Introduction Neuroendocrine tumors (NETs) comprise a heterogeneous spectrum of neoplasms. NETs are commonly subclassified into two broad subgroups according to their site of origin: pancreatic NETs (pNETs) are thought to arise from the endocrine

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0390
Volume/Issue:
Volume 20: Issue 3
Free access