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Anela Blažević Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Wouter T Zandee Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Gaston J H Franssen Department of Surgery, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Johannes Hofland Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Marie-Louise F van Velthuysen Department of Pathology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Leo J Hofland Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Richard A Feelders Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Wouter W de Herder Department of Internal Medicine, Section Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumours, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Introduction Small intestinal neuroendocrine tumours (SI-NETs) are rare neoplasms with an incidence of approximately 0.2–1.2 per 100,000 individuals. However, due to the mostly indolent nature and increasing incidence, their prevalence is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0282
Volume/Issue:
Volume 25: Issue 3
Free access
Mohid S Khan Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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Martyn E Caplin Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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as a curative approach. Often neuroendocrine tumours (NETs) have metastases present at the time of diagnosis; therefore, curative resection is usually not possible, and when surgery is undertaken, it can be considered palliative in view of residual

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0271
Volume/Issue:
Volume 18: Issue S1
Free access
Christodoulos P Pipinikas Medical Genomics Laboratory, University College London Cancer Institute, London, UK

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Alison M Berner Medical Genomics Laboratory, University College London Cancer Institute, London, UK

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Teresa Sposito Medical Genomics Laboratory, University College London Cancer Institute, London, UK

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Christina Thirlwell Medical Genomics Laboratory, University College London Cancer Institute, London, UK
Neuroendocrine Tumour Unit and Department of Oncology, Royal Free Hospital, London, UK

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), most commonly liver metastases, 5-year survival is 16–46% ( Mignon et al. 2000 , Viúdez et al. 2016 , Batukbhai et al. 2019 ) ( Fig. 1A ). Figure 1 Overview of the multi-layered pancreatic neuroendocrine tumours (PanNET) complexity. (A

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0175
Volume/Issue:
Volume 26: Issue 9
Free access
C Bouvier Neuroendocrine Tumour Unit, Royal Free Hospital, London NW3 2QG, UK.

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Nurse developments in the management of neuroendocrine tumours have changed significantly over the past three years. At the Royal Free Hospital we set up the nurse specialist role due to the expansion of patients being referred to the specialist unit, and the obvious need for a nursing input into their care. The nurse specialist can make a significant contribution within the context of a multidisciplinary team especially in the production of guidelines and policies to ensure and maintain high standards of practice, education for the patient, and the provision of expertise and security that the patient requires when diagnosed with a rare disease.

Article Type:
Abstract
Volume/Issue:
Volume 10: Issue 4
Free access
Anela Blažević Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Johannes Hofland Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Leo J Hofland Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Richard A Feelders Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Wouter W de Herder Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus University Medical Center (Erasmus MC) and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Introduction Small intestinal neuroendocrine tumours (SI-NETs) are rare and mostly slow-growing neoplasms originating from the enterochromaffin (EC) cells of the intestine ( de Herder 2005 , Yao et al . 2008 ). EC cells are chemo- and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0380
Volume/Issue:
Volume 25: Issue 3
Free access
Helen C Miller Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Adam E Frampton Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Anna Malczewska Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK
Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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Silvia Ottaviani Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Euan A Stronach Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Rashpal Flora Department of Histopathology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK

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Daniel Kaemmerer Zentralklinik Bad Berka GmbH, Robert-Koch-Allee, Bad Berka, Germany

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Gert Schwach Institute of Pathophysiology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Roswitha Pfragner Institute of Pathophysiology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Omar Faiz St Mark’s Hospital, Harrow, UK

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Beata Kos-Kudła Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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George B Hanna Academic Surgical Unit, Department of Surgery and Cancer, Imperial College, St Mary’s Campus, London, UK

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Justin Stebbing Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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Leandro Castellano Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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Andrea Frilling Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Introduction Small bowel neuroendocrine tumours (SBNETs) account for the most common neuroendocrine neoplasm of the gastroenteropancreatic (GEP) system ( Lawrence et al . 2011 ). Their incidence is steadily increasing; in males, 2.7-fold

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0044
Volume/Issue:
Volume 23: Issue 9
Free access
R Srirajaskanthan
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G Dancey Neuroendocrine Tumour Unit, UCL Cancer Institute, Cancer Research UK and UCL Cancer Trials Centre, Department of Histopathology, Royal Free Hospital, London NW3 2QG, UK

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A Hackshaw Neuroendocrine Tumour Unit, UCL Cancer Institute, Cancer Research UK and UCL Cancer Trials Centre, Department of Histopathology, Royal Free Hospital, London NW3 2QG, UK

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T Luong Neuroendocrine Tumour Unit, UCL Cancer Institute, Cancer Research UK and UCL Cancer Trials Centre, Department of Histopathology, Royal Free Hospital, London NW3 2QG, UK

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M E Caplin
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T Meyer Neuroendocrine Tumour Unit, UCL Cancer Institute, Cancer Research UK and UCL Cancer Trials Centre, Department of Histopathology, Royal Free Hospital, London NW3 2QG, UK

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). Neuroendocrine tumours (NETs) are uncommon tumours that can occur in almost any organ and are thought to originate from neuroendocrine cells ( Caplin et al . 1998 , Modlin et al . 2008 ). The most common sites of origin is from gastroenteropancreatic tract

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0089
Volume/Issue:
Volume 16: Issue 3
Free access
Alexa Childs Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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Amy Kirkwood Cancer Research UK & UCL Cancer Trials Centre, London, UK

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Julien Edeline UCL Cancer Institute, UCL, London, UK

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Tu Vinh Luong Department of Pathology, Royal Free London NHS Foundation Trust, London, UK

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Jennifer Watkins Department of Pathology, Royal Free London NHS Foundation Trust, London, UK

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Angela Lamarca Institute of Cancer Sciences, University of Manchester/The Christie NHS Foundation Trust, Manchester, UK

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Doraid Alrifai King’s College Hospital NHS Foundation Trust, London, UK

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Phyllis Nsiah-Sarbeng Department of Radiology, Royal Free London NHS Foundation Trust, London, UK

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Roopinder Gillmore Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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Astrid Mayer Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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Christina Thirlwell Department of Oncology, Royal Free London NHS Foundation Trust, London, UK
UCL Cancer Institute, UCL, London, UK

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Debashis Sarker King’s College Hospital NHS Foundation Trust, London, UK

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Juan W Valle Institute of Cancer Sciences, University of Manchester/The Christie NHS Foundation Trust, Manchester, UK

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Tim Meyer Department of Oncology, Royal Free London NHS Foundation Trust, London, UK
UCL Cancer Institute, UCL, London, UK

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Introduction Neuroendocrine tumours (NETs) are exceptional in terms of their heterogeneity with respect to clinical behaviour and prognosis. Patients may live with low-grade, indolent tumours for 20years while the outlook for high

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0099
Volume/Issue:
Volume 23: Issue 7
Free access
Luohai Chen Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Institute for Liver and Digestive Disease, Royal Free Hospital, University College London, London, UK

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Gopinath Gnanasegaran Department of Nuclear Medicine, Royal Free London NHS Foundation, London, UK

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Dalvinder Mandair Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Christos Toumpanakis Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Martyn Caplin Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Shaunak Navalkissoor Department of Nuclear Medicine, Royal Free London NHS Foundation, London, UK

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Introduction 177 Lutetium-DOTA 0 -Tyr 3 -octreotate ( 177 Lu-Dotatate) is a peptide receptor radionuclide therapy (PRRT) licensed for treatment in patients with advanced well-differentiated gastroenteropancreatic neuroendocrine tumours (NET

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0248
Volume/Issue:
Volume 29: Issue 2
Restricted access
Tim J Takkenkamp Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Mathilde Jalving Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Frederik J H Hoogwater Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Annemiek M E Walenkamp Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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neuroendocrine tumours in adult patients is 6.98 per 100,000 people, according to the 2012 Surveillance, Epidemiology, and End Results (SEER) data, and this number is increasing ( Dasari et al. 2017 ). Median overall survival of all patients with NETs is 9

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0113
Volume/Issue:
Volume 27: Issue 9
Free access