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Eyun Song Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Dong Eun Song Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Jonghwa Ahn Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Tae Yong Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Min Ji Jeon Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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Won Gu Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea

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tumors is especially crucial. In this study, we defined advanced thyroid cancers as follicular-cell-derived thyroid cancers with distant metastases (DTCs, PDTCs, and ATCs) and performed targeted next-generation sequencing (NGS) for identifying the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0452
Volume/Issue:
Volume 27: Issue 5
Restricted access
Darren Cowzer Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ronak H Shah Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Joanne F Chou Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Ritika Kundra Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Sippy Punn Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Laura Fiedler Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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April DeMore Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Marinela Capanu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Michael F Berger Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Pathology and laboratory medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Diane Reidy-Lagunes Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Medical College of Cornell University, New York, New York, USA

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Nitya Raj Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill Medical College of Cornell University, New York, New York, USA

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identified by next-generation sequencing (NGS) in matched tumor tissue and plasma. Given prior reports of increasing mutagenesis following alkylating agent therapy, we also investigated the effects of alkylating agents on cfDNA concentration and mutation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0292
Volume/Issue:
Volume 31: Issue 4
Restricted access
Susan J Hsiao Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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Yuri E Nikiforov Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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panels that can be used in FNA samples. The expanded panels can detect more mutations and with higher sensitivity, which is expected to increase significantly the sensitivity and NPV of mutational panels. Next generation sequencing (NGS) technologies

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0166
Volume/Issue:
Volume 21: Issue 5
Free access
Alexa Childs UCL Cancer Institute, University College London, London, UK

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Christopher D Steele UCL Cancer Institute, University College London, London, UK

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Clare Vesely UCL Cancer Institute, University College London, London, UK

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Francesca M Rizzo UCL Cancer Institute, University College London, London, UK

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Leah Ensell UCL Cancer Institute, University College London, London, UK

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Helen Lowe UCL Cancer Institute, University College London, London, UK

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Pawan Dhami UCL Cancer Institute, University College London, London, UK

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Heli Vaikkinen UCL Cancer Institute, University College London, London, UK

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Tu Vinh Luong Department of Histopathology, Royal Free London NHS Foundation Trust, London, UK

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Lucia Conde UCL Cancer Institute, University College London, London, UK

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Javier Herrero UCL Cancer Institute, University College London, London, UK

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Martyn Caplin Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK

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Christos Toumpanakis Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK

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Christina Thirlwell UCL Cancer Institute, University College London, London, UK
Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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John A Hartley UCL Cancer Institute, University College London, London, UK

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Nischalan Pillay Research Department of Pathology, Cancer Institute, University College London, London, UK
Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK

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Tim Meyer UCL Cancer Institute, University College London, London, UK
Department of Oncology, Royal Free London NHS Foundation Trust, London, UK

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. Technological advances in whole-genome amplification (WGA) and next-generation sequencing (NGS) methods now permit genomic analysis at the single-cell level and are uniquely placed to unravel complex clonal structures and track tumor evolution over time

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0179
Volume/Issue:
Volume 28: Issue 9
Open access
Vincenzo Marotta IOS & COLEMAN Srl, Naples, Italy

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Concetta Sciammarella IOS & COLEMAN Srl, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS “Fondazione G. Pascale”, Naples, Italy

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innovative next-generation sequencing (NGS) techniques ( Agrawal et al . 2014 ). Importantly, a great effort was made for attesting the driver role of identified mutations. This represented the most accurate attempt of molecular characterisation of PTC

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0372
Volume/Issue:
Volume 23: Issue 11
Free access
Isobel C Mouat Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Kei Omata Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Andrew S McDaniel Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Namita G Hattangady Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Debnita Talapatra Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Andi K Cani Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Daniel H Hovelson Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Scott A Tomlins Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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William E Rainey Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Gary D Hammer Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Thomas J Giordano Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Tobias Else Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA

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slides for AC100-112 and YY for AC113-119, using the AllPrep DNA/RNA FFPE kit (QIAGEN) as described previously ( Warrick et al . 2015 ). Next-generation sequencing For each sample, 20 ng of isolated gDNA was used for barcoded library generation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0385
Volume/Issue:
Volume 26: Issue 2
Free access
Arivarasan Karunamurthy Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Federica Panebianco Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Susan J Hsiao Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Jennie Vorhauer Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Simion Chiosea Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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mutations in exons 2, 5, and 6 was performed using Sanger sequencing or next-generation sequencing panel (ThyroSeq v2) as previously described ( Nikiforov et al. 2014 ). In addition to EIF1AX , the panel included the analysis of point mutations in the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0043
Volume/Issue:
Volume 23: Issue 4
Free access
Nitya Raj Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Youyun Zheng Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Haley Hauser Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Joanne Chou Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Johnathan Rafailov Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jad Bou-Ayache Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Peter Sawan Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jamie Chaft Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jennifer Chan Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Kimberly Perez Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Charles Rudin Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Laura Tang Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Diane Reidy-Lagunes Memorial Sloan Kettering Cancer Center, New York, New York, USA

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of ribociclib and everolimus ( Sanchez-Vega et al. 2018 ). Next-generation sequencing (NGS) was performed in the tumor samples using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) platform

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0446
Volume/Issue:
Volume 28: Issue 4
Restricted access
Ying Ying Sung Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore

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Edwin Cheung Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore

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( Chng & Cheung 2012 ). For example, by coupling chromatin immunoprecipitation with microarray (ChIP-Chip) as well as next-generation sequencing (ChIP-Seq), researchers have been able to obtain high-resolution genome-wide binding site maps of AR and other

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0326
Volume/Issue:
Volume 21: Issue 1
Free access
Koen M A Dreijerink Department of Endocrinology VU University Medical Center, Amsterdam, The Netherlands

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H T Marc Timmers German Cancer Consortium (DKTK) partner site Freiburg German Cancer Research Center (DKFZ) and Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany

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Myles Brown Department of Medical Oncology Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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reported for several of the target genes mentioned above. However, by combining ChIP with high-throughput analyses of bound DNA, such as a DNA chip (ChIP on a chip) or more recently next-generation sequencing (ChIP-seq) the presence of a given

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0281
Volume/Issue:
Volume 24: Issue 10
Free access