Filter

Refine by collections

Refine by date

—

Refine by access

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 103 items for :

  • "pancreatic NETs" x
  • Refine by access: All content x
Clear All
C R C Pieterman Section of Surgical Endocrinology, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

Search for other papers by C R C Pieterman in
Google Scholar
PubMed Close
,
S M Sadowski Endocrine Surgery, Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

Search for other papers by S M Sadowski in
Google Scholar
PubMed Close
,
J E Maxwell Department of Surgical Oncology, University of Texas MD Anderson Cancer Center

Search for other papers by J E Maxwell in
Google Scholar
PubMed Close
,
M H G Katz Department of Surgical Oncology, University of Texas MD Anderson Cancer Center

Search for other papers by M H G Katz in
Google Scholar
PubMed Close
,
K E Lines Academic Endocrine Unit, Radcliffe Department of Medicine, OCDEM, University of Oxford, Oxford, UK

Search for other papers by K E Lines in
Google Scholar
PubMed Close
,
C M Heaphy Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by C M Heaphy in
Google Scholar
PubMed Close
,
A Tirosh Neuroendocrine Tumors Service, Division of Endocrinology, Metabolism and Diabetes, The Chaim Sheba Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Search for other papers by A Tirosh in
Google Scholar
PubMed Close
,
J E Blau Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

Search for other papers by J E Blau in
Google Scholar
PubMed Close
,
N D Perrier Section of Surgical Endocrinology, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by N D Perrier in
Google Scholar
PubMed Close
,
M A Lewis Gastrointestinal Oncology, Intermountain Healthcare, Murray, Utah, USA
American Multiple Endocrine Neoplasia Support (AMENSupport), Maryville, Tennessee, USA

Search for other papers by M A Lewis in
Google Scholar
PubMed Close
,
J P Metzcar Association of Multiple Endocrine Neoplasia Disorders (AMEND), Bloomington, Indiana, USA
Departments of Intelligent Systems Engineering and Informatics, Indiana University, Bloomington, Indiana, USA

Search for other papers by J P Metzcar in
Google Scholar
PubMed Close
,
D M Halperin Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by D M Halperin in
Google Scholar
PubMed Close
,
R V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, OCDEM, University of Oxford, Oxford, UK

Search for other papers by R V Thakker in
Google Scholar
PubMed Close
, and
G D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

Search for other papers by G D Valk in
Google Scholar
PubMed Close

,000 ( Chandrasekharappa et al. 1997 ). By the age of 80 more than 80% of the patients will have developed a duodenopancreatic NET ( de Laat et al. 2016 ) and multifocality is common. Non-functional pancreatic NETs (nf-PanNETs) are the most common type of PanNET in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0441
Volume/Issue:
Volume 27: Issue 8
Free access
Hiroki Ueda Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Hiroki Ueda in
Google Scholar
PubMed Close
,
Yoshimitsu Akiyama Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Yoshimitsu Akiyama in
Google Scholar
PubMed Close
,
Shu Shimada Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Shu Shimada in
Google Scholar
PubMed Close
,
Kaoru Mogushi Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Kaoru Mogushi in
Google Scholar
PubMed Close
,
Misaki Serizawa Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Misaki Serizawa in
Google Scholar
PubMed Close
,
Satoshi Matsumura Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Satoshi Matsumura in
Google Scholar
PubMed Close
,
Yusuke Mitsunori Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Yusuke Mitsunori in
Google Scholar
PubMed Close
,
Arihiro Aihara Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Arihiro Aihara in
Google Scholar
PubMed Close
,
Daisuke Ban Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Daisuke Ban in
Google Scholar
PubMed Close
,
Takanori Ochiai Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Takanori Ochiai in
Google Scholar
PubMed Close
,
Atsushi Kudo Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Atsushi Kudo in
Google Scholar
PubMed Close
,
Minoru Tanabe Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Minoru Tanabe in
Google Scholar
PubMed Close
, and
Shinji Tanaka Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Search for other papers by Shinji Tanaka in
Google Scholar
PubMed Close

Pancreatic neuroendocrine tumors (PanNETs) have considerable malignant potential. Frequent somatic mutations and loss of DAXX protein expression have been found in PanNETs. DAXX is known as a transcriptional repressor; however, molecular functions underlying DAXX loss remain unclear in PanNETs. We evaluated DAXX expression by immunohistochemistry in 44 PanNETs. DAXX-knockdown (KD) and -knockout (KO) PanNET cells were analyzed for in vitro and vivo. The target genes were screened by microarray and chromatin immunoprecipitation (ChIP) assays for DAXX, histone H3.3 and H3K9me3 complex. In clinicopathological features, low DAXX expression was significantly correlated with nonfunctional tumors, higher Ki-67 index and WHO grade. Microarray and ChIP assays of DAXX-KD/KO identified 12 genes as the direct targets of DAXX transcriptional repressor. Among them, expression of five genes including STC2 was suppressed by DAXX/H3.3/H3K9me3 pathway. DAXX-KD/KO cells enhanced sphere forming activity, but its effect was suppressed by knockdown of STC2. In xenograft models, tumorigenicity and tumor vessel density were significantly increased in DAXX-KO cells with high expression of STC2. Clinically, higher recurrence rate was recognized in PanNETs with low expression of DAXX and high expression of STC2 than others (P = 0.018). Our data suggest that DAXX plays as a tumor suppressor and DAXX/H3.3 complex suppresses target genes by promoting H3K9me3 in PanNETs. Combination of DAXX loss and its target gene STC2 overexpression might be effective biomarkers and therapeutic candidates.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0328
Volume/Issue:
Volume 25: Issue 6
Free access
Olga Lakiza Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

Search for other papers by Olga Lakiza in
Google Scholar
PubMed Close
,
Julian Lutze Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA

Search for other papers by Julian Lutze in
Google Scholar
PubMed Close
,
Alyx Vogle Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

Search for other papers by Alyx Vogle in
Google Scholar
PubMed Close
,
Jelani Williams Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

Search for other papers by Jelani Williams in
Google Scholar
PubMed Close
,
Abde Abukdheir Division of Hematology, Oncology, and Cell Therapy, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA

Search for other papers by Abde Abukdheir in
Google Scholar
PubMed Close
,
Paul Miller Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

Search for other papers by Paul Miller in
Google Scholar
PubMed Close
,
Chih-Yi ‘Andy’ Liao Division of Hematology and Oncology, Department of Internal Medicine, University of Chicago, Chicago, Illinois, USA

Search for other papers by Chih-Yi ‘Andy’ Liao in
Google Scholar
PubMed Close
,
Sean P Pitroda Department of Radiation Oncology and Cellular Biology, University of Chicago, Chicago, Illinois, USA

Search for other papers by Sean P Pitroda in
Google Scholar
PubMed Close
,
Carlos Martinez Department of Radiation Oncology and Cellular Biology, University of Chicago, Chicago, Illinois, USA

Search for other papers by Carlos Martinez in
Google Scholar
PubMed Close
,
Andrea Olivas Department of Pathology, University of Chicago, Chicago, Illinois, USA

Search for other papers by Andrea Olivas in
Google Scholar
PubMed Close
,
Namrata Setia Department of Pathology, University of Chicago, Chicago, Illinois, USA

Search for other papers by Namrata Setia in
Google Scholar
PubMed Close
,
Stephen J Kron Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, USA

Search for other papers by Stephen J Kron in
Google Scholar
PubMed Close
,
Ralph R Weichselbaum Department of Radiation Oncology and Cellular Biology, University of Chicago, Chicago, Illinois, USA
Ludwig Center for Metastasis Research, University of Chicago, Chicago, Illinois, USA

Search for other papers by Ralph R Weichselbaum in
Google Scholar
PubMed Close
, and
Xavier M Keutgen Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

Search for other papers by Xavier M Keutgen in
Google Scholar
PubMed Close

Somatic MEN1 mutations occur in up to 50% of pancreatic neuroendocrine tumors (PanNETs). Clinical studies have shown that radiation therapy (IR) is effective in a subset of PanNETs, but it remains unclear why some patients respond better to IR than others. Herein, we study whether MEN1 loss of function increases radiosensitivity of PanNETs and determine its effect on DNA double-strand break (DSB) repair. After creating a MEN1 knockout PanNET cell line, we confirmed reduced DSB repair capacity in MEN1-deficient cells and linked these findings to a defect in homologous recombination, as well as reduced BRCA2 expression levels. Consistent with this model, we found that MEN1 mutant cells displayed increased sensitivity to the highly trapping poly (ADP-ribose) polymerase (PARP) 1 inhibitor talazoparib in vitro. Our results suggest that combining IR with PARP inhibition may be beneficial in patients with PanNETs and MEN1 loss of function.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0247
Volume/Issue:
Volume 29: Issue 4
Restricted access
Nele Garbrecht
Search for other papers by Nele Garbrecht in
Google Scholar
PubMed Close
,
Martin Anlauf
Search for other papers by Martin Anlauf in
Google Scholar
PubMed Close
,
Anja Schmitt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Anja Schmitt in
Google Scholar
PubMed Close
,
Tobias Henopp
Search for other papers by Tobias Henopp in
Google Scholar
PubMed Close
,
Bence Sipos
Search for other papers by Bence Sipos in
Google Scholar
PubMed Close
,
Andreas Raffel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Andreas Raffel in
Google Scholar
PubMed Close
,
Claus F Eisenberger Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Claus F Eisenberger in
Google Scholar
PubMed Close
,
Wolfram T Knoefel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Wolfram T Knoefel in
Google Scholar
PubMed Close
,
Marianne Pavel Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Marianne Pavel in
Google Scholar
PubMed Close
,
Christian Fottner Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Christian Fottner in
Google Scholar
PubMed Close
,
Thomas J Musholt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Thomas J Musholt in
Google Scholar
PubMed Close
,
Anja Rinke Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Anja Rinke in
Google Scholar
PubMed Close
,
Rudolf Arnold Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Rudolf Arnold in
Google Scholar
PubMed Close
,
Uta Berndt Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Uta Berndt in
Google Scholar
PubMed Close
,
Ursula Plöckinger Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Ursula Plöckinger in
Google Scholar
PubMed Close
,
Bertram Wiedenmann Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Bertram Wiedenmann in
Google Scholar
PubMed Close
,
Holger Moch Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Holger Moch in
Google Scholar
PubMed Close
,
Philipp U Heitz Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Philipp U Heitz in
Google Scholar
PubMed Close
,
Paul Komminoth Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany
Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Paul Komminoth in
Google Scholar
PubMed Close
,
Aurel Perren Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany
Department of Pathology, Department of Pathology, Department of General, Department of Gastroenterology and Endocrinology, Department of Endocrinology, Department of General and Abdominal Surgery, Department of Gastroenterology and Endocrinology, Department of Hepatology and Gastroenterology, Department of Pathology, Institute of Pathology, University of Kiel, Michaelisstr. 11, 24105 Kiel, Germany

Search for other papers by Aurel Perren in
Google Scholar
PubMed Close
, and
Günter Klöppel
Search for other papers by Günter Klöppel in
Google Scholar
PubMed Close

functional activity is therefore based on reports of single or small series of patients and reviews ( Hamid et al . 1986 , Tomic & Warner 1996 , Soga & Yakuwa 1999 ). In this study, we analyzed a series of 623 resected duodenal and pancreatic NETs by

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0157
Volume/Issue:
Volume 15: Issue 1
Free access
Nicole Panarelli Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Nicole Panarelli in
Google Scholar
PubMed Close
,
Kathrin Tyryshkin Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

Search for other papers by Kathrin Tyryshkin in
Google Scholar
PubMed Close
,
Justin Jong Mun Wong Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

Search for other papers by Justin Jong Mun Wong in
Google Scholar
PubMed Close
,
Adrianna Majewski Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

Search for other papers by Adrianna Majewski in
Google Scholar
PubMed Close
,
Xiaojing Yang Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

Search for other papers by Xiaojing Yang in
Google Scholar
PubMed Close
,
Theresa Scognamiglio Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Theresa Scognamiglio in
Google Scholar
PubMed Close
,
Michelle Kang Kim Center for Carcinoid and Neuroendocrine Tumors of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Search for other papers by Michelle Kang Kim in
Google Scholar
PubMed Close
,
Kimberly Bogardus HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

Search for other papers by Kimberly Bogardus in
Google Scholar
PubMed Close
,
Thomas Tuschl HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

Search for other papers by Thomas Tuschl in
Google Scholar
PubMed Close
,
Yao-Tseng Chen Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

Search for other papers by Yao-Tseng Chen in
Google Scholar
PubMed Close
, and
Neil Renwick Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

Search for other papers by Neil Renwick in
Google Scholar
PubMed Close

ileal and appendiceal NETs (comparison B) and rectal and pancreatic NETs (comparison C). We also compared miRNA expression differences between NETs from each anatomic site of origin (i.e. pancreas, ileum, appendix or rectum) and the remaining three GEP

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0244
Volume/Issue:
Volume 26: Issue 1
Free access
Elke Tatjana Aristizabal Prada Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Elke Tatjana Aristizabal Prada in
Google Scholar
PubMed Close
,
Vera Heinzle Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Vera Heinzle in
Google Scholar
PubMed Close
,
Thomas Knösel Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Thomas Knösel in
Google Scholar
PubMed Close
,
Svenja Nölting Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Svenja Nölting in
Google Scholar
PubMed Close
,
Gerald Spöttl Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Gerald Spöttl in
Google Scholar
PubMed Close
,
Julian Maurer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Julian Maurer in
Google Scholar
PubMed Close
,
Christine Spitzweg Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Christine Spitzweg in
Google Scholar
PubMed Close
,
Martin Angele Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Martin Angele in
Google Scholar
PubMed Close
,
Nina Schmidt Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Nina Schmidt in
Google Scholar
PubMed Close
,
Felix Beuschlein Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland

Search for other papers by Felix Beuschlein in
Google Scholar
PubMed Close
,
Günter K Stalla Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany

Search for other papers by Günter K Stalla in
Google Scholar
PubMed Close
,
Rainer Blaser Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

Search for other papers by Rainer Blaser in
Google Scholar
PubMed Close
,
Klaus A Kuhn Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

Search for other papers by Klaus A Kuhn in
Google Scholar
PubMed Close
, and
Christoph J Auernhammer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Christoph J Auernhammer in
Google Scholar
PubMed Close

/33 (33%) of all pNETs ( Table 2 ). These data demonstrate a high prevalence of Trk receptor expression in pancreatic NETs. Therefore, immunohistochemical or molecular screening for Trk expression in pNETs might be useful as a predictive marker to select

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0201
Volume/Issue:
Volume 25: Issue 5
Free access
Maria Chiara Zatelli Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

Search for other papers by Maria Chiara Zatelli in
Google Scholar
PubMed Close
,
Giuseppe Fanciulli Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

Search for other papers by Giuseppe Fanciulli in
Google Scholar
PubMed Close
,
Pasqualino Malandrino Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

Search for other papers by Pasqualino Malandrino in
Google Scholar
PubMed Close
,
Valeria Ramundo Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

Search for other papers by Valeria Ramundo in
Google Scholar
PubMed Close
,
Antongiulio Faggiano Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

Search for other papers by Antongiulio Faggiano in
Google Scholar
PubMed Close
,
Annamaria Colao Section of Endocrinology and Internal Medicine, Neuroendocrine Tumours Unit, Endocrinology Unit, Department of Clinical Medicine and Surgery, Thyroid and Parathyroid Surgery Unit, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124 Cona – Ferrara, Italy

Search for other papers by Annamaria Colao in
Google Scholar
PubMed Close
, and
on behalf of NIKE Group
Search for other papers by on behalf of NIKE Group in
Google Scholar
PubMed Close

increased phospho -AKT and decreased phospho -mTOR expression. Spada et al . (2014) observed that among 36 patients with metastatic gastro-entero-pancreatic NETs treated with everolimus 10 mg once daily, patients with Ki-67 ≤20% (30/36) displayed a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0413
Volume/Issue:
Volume 23: Issue 3
Free access
Louis de Mestier Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

Search for other papers by Louis de Mestier in
Google Scholar
PubMed Close
,
Anne Couvelard Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

Search for other papers by Anne Couvelard in
Google Scholar
PubMed Close
,
Anela Blazevic Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

Search for other papers by Anela Blazevic in
Google Scholar
PubMed Close
,
Olivia Hentic Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France

Search for other papers by Olivia Hentic in
Google Scholar
PubMed Close
,
Wouter W de Herder Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

Search for other papers by Wouter W de Herder in
Google Scholar
PubMed Close
,
Vinciane Rebours Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

Search for other papers by Vinciane Rebours in
Google Scholar
PubMed Close
,
Valérie Paradis Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

Search for other papers by Valérie Paradis in
Google Scholar
PubMed Close
,
Philippe Ruszniewski Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

Search for other papers by Philippe Ruszniewski in
Google Scholar
PubMed Close
,
Leo J Hofland Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

Search for other papers by Leo J Hofland in
Google Scholar
PubMed Close
, and
Jérôme Cros Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

Search for other papers by Jérôme Cros in
Google Scholar
PubMed Close

tumor burden and/or high Ki67 index), or in a neoadjuvant setting aiming to obtain tumor shrinkage ( Frilling et al. 2014 , Pavel et al. 2016 ). Of note, chemotherapy is especially relevant in pancreatic NETs (PanNETs), which are more chemo

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0227
Volume/Issue:
Volume 27: Issue 10
Free access
Maria Chiara Zatelli
Search for other papers by Maria Chiara Zatelli in
Google Scholar
PubMed Close
,
Mirella Torta
Search for other papers by Mirella Torta in
Google Scholar
PubMed Close
,
Antonette Leon
Search for other papers by Antonette Leon in
Google Scholar
PubMed Close
,
Maria Rosaria Ambrosio
Search for other papers by Maria Rosaria Ambrosio in
Google Scholar
PubMed Close
,
Massimo Gion
Search for other papers by Massimo Gion in
Google Scholar
PubMed Close
,
Paola Tomassetti
Search for other papers by Paola Tomassetti in
Google Scholar
PubMed Close
,
Filippo De Braud
Search for other papers by Filippo De Braud in
Google Scholar
PubMed Close
,
Gianfranco Delle Fave
Search for other papers by Gianfranco Delle Fave in
Google Scholar
PubMed Close
,
Luigi Dogliotti
Search for other papers by Luigi Dogliotti in
Google Scholar
PubMed Close
, and
Ettore C degli Uberti
Search for other papers by Ettore C degli Uberti in
Google Scholar
PubMed Close

for pancreatic NETs, with the chosen cutoff levels for both IRMA and ELISA assays, PPV was 84% and NPV was 78%, with 90% specificity and 68% sensitivity. On the other hand, PPV and NPV for stomach were 22 and 79% with the ELISA assay. Table

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0001
Volume/Issue:
Volume 14: Issue 2
Free access
Anna Karpathakis University College London Cancer Institute, Neuroendocrine Tumour Unit, Paul O'Gorman Building, Huntley Street, London WC1E 6BT, UK
University College London Cancer Institute, Neuroendocrine Tumour Unit, Paul O'Gorman Building, Huntley Street, London WC1E 6BT, UK

Search for other papers by Anna Karpathakis in
Google Scholar
PubMed Close
,
Martyn Caplin University College London Cancer Institute, Neuroendocrine Tumour Unit, Paul O'Gorman Building, Huntley Street, London WC1E 6BT, UK

Search for other papers by Martyn Caplin in
Google Scholar
PubMed Close
, and
Christina Thirlwell University College London Cancer Institute, Neuroendocrine Tumour Unit, Paul O'Gorman Building, Huntley Street, London WC1E 6BT, UK
University College London Cancer Institute, Neuroendocrine Tumour Unit, Paul O'Gorman Building, Huntley Street, London WC1E 6BT, UK

Search for other papers by Christina Thirlwell in
Google Scholar
PubMed Close

and discuss recent advances in the elucidation of the biological pathways involved in the development of pancreatic NETs (pNETs), focusing on the use and suggested scheduling of sunitinib and everolimus. Pathogenesis NETs are ‘rare’ tumours with a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0050
Volume/Issue:
Volume 19: Issue 3
Free access