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Feng Wu Department of Endocrinology, The Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Fuxingzi Li Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Xiao Lin Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Feng Xu Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Rong-Rong Cui Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Jia-Yu Zhong Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Ting Zhu Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Su-Kang Shan Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Xiao-Bo Liao Department of Cardiovascular Surgery, the Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Ling-Qing Yuan Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Zhao-Hui Mo Department of Endocrinology, The Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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/bronchus cancer, colon/rectum and uterine corpus cancer ( Jemal et al. 2008 ). Among the several histological subtypes of thyroid cancer, papillary thyroid cancer (PTC) is the most common pathological subtype, accounting for approximately 80–90% of all thyroid

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Guo-Qiang Zhang Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chuang Xi Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chen-Tian Shen Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hong-Jun Song Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Quan-Yong Luo Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhong-Ling Qiu Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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steady increase in the incidence of papillary thyroid cancer (PTC). PTC, which arises from thyroid follicular epithelial cells, accounts for approximately 84% of thyroid cancers ( Lim et al. 2017 ). This subtype maintains the typical differentiation

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Lauren N Pontius Duke University Medical Center, Durham, North Carolina, USA

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Linda M Youngwirth Duke University Medical Center, Durham, North Carolina, USA

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Samantha M Thomas Duke University Medical Center, Durham, North Carolina, USA

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Randall P Scheri Duke University Medical Center, Durham, North Carolina, USA

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Sanziana A Roman Duke University Medical Center, Durham, North Carolina, USA

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Julie A Sosa Duke University Medical Center, Durham, North Carolina, USA

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Introduction Thyroid cancer is the fastest increasing cancer in the United States among both men and women, largely as a result of an increase in the incidence of papillary thyroid cancer (PTC), which now represents approximately 90% of all

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Kwon Joong Na Department of Community Health, Korea Health Promotion Institute, Seoul, Republic of Korea
Department of Clinical Medical Sciences, Seoul National University, College of Medicine, Seoul, Republic of Korea

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Hongyoon Choi Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Cheonan Public Health Center, Chungnam, Republic of Korea

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Introduction Thyroid cancer is the most common endocrine malignancy, and its incidence has increased almost 3-fold over the past decades ( Chen et al . 2009 , Siegel et al . 2016 ). Papillary thyroid cancer (PTC) is the predominant

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Myungwoo Nam Department of Medicine, Lincoln Medical and Mental Health Center, Bronx, New York, USA

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Woojung Yang Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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Hye Sung Kim Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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Jewel Park Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

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Gahee Park Lunit Inc, Oncology group, Seoul, Republic of Korea

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Sukjun Kim Lunit Inc, Oncology group, Seoul, Republic of Korea

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Sanghoon Song Lunit Inc, Oncology group, Seoul, Republic of Korea

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Chan-Young Ock Lunit Inc, Oncology group, Seoul, Republic of Korea

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Victor G Wang Department of Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA
The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

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Jeffrey H Chuang Department of Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA
The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

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Young Kwang Chae Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA

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higher incidence of lymph node metastasis ( P < 0.001). Table 1 provides more details about baseline characteristics. Table 1 Demographics and baseline characteristics of patients with papillary thyroid cancer. n (%) Desert

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Dong Hyun Seo Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

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Seul Gi Lee Yonsei University Graduate School of Medical Science, Seoul, South Korea

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Soon Min Choi Department of Surgery, Hallym Hospital, Incheon, South Korea

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Ha Yan Kim Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea

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Sunmi Park Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

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Sang Geun Jung Department of Gynecological Oncology, Bundang CHA Medical Center, CHA University Gyeonggi-do, South Korea

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Young Suk Jo Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

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Jandee Lee Department of Surgery, Open NBI Convergence Technology Research Laboratory, Yonsei University College of Medicine, Seoul, South Korea

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cancer, papillary thyroid cancer (PTC) is the most frequent subtype. The global rise of thyroid cancer incidence has been attributed to the early detection of papillary thyroid microcarcinoma (PTMC) ( Davies & Welch 2006 , 2014 , Ahn et al. 2014

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Xiaoli Liu Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Chunhai Zhang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Xiaomiao Wang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Can Cui Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Hanwen Cui Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Baishu Zhu Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Anqi Chen Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Lu Zhang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Jingwei Xin Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Qingfeng Fu Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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Gianlorenzo Dionigi Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Division of Surgery, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy

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Hui Sun Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun, Jilin, China

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papillary thyroid cancer (PTC), follicular thyroid cancer, anaplastic thyroid cancer (ATC) and medullary thyroid cancer based on histological classification, where PTC as the most common histological type accounts for approximately 90% of all thyroid cancer

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R Michael Tuttle Endocrinology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Duan Li Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Fourat Ridouani Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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thyroid cancer. However, the last decade has seen a shift toward acceptance of more minimalistic management options such as active surveillance or thyroid lobectomy for properly selected patients with low-risk papillary thyroid cancer ( Haugen et al

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Päivi Siironen
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Ari Ristimäki
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Kirsi Narko
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Stig Nordling
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Johanna Louhimo
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Sture Andersson
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Reijo Haapiainen
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Caj Haglund
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Introduction Papillary thyroid cancer (PTC) is a unique cancer for two reasons; first, its prognosis depends largely on age, and secondly, lymph node metastases (LNM) do not necessarily indicate poor survival. Many authors have

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Dan Luo National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China

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Shaohua Zhan National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China

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Wenchao Xia National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China

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Liang Huang Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Wei Ge National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China

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Tianxiao Wang Department of Head and Neck Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing, China

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much of the world ( Cabanillas et al. 2016 ). The most common type of thyroid cancer is papillary thyroid cancer (PTC), comprising almost 80% of all cases ( Schneider & Chen 2013 ). Differentiated PTC usually has an excellent prognosis with 5-year

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