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Ramona Dadu Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX, USA

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Rozita Bagheri-Yarmand Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX, USA

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Matthew D Ringel Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Columbus, OH, USA

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Elizabeth G Grubbs Department of Surgical Oncology, The University of Texas MD Anderson Cancer, Houston, TX, USA

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Mark Zafereo Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer, Houston, TX, USA

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Gilbert Cote Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX, USA

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Robert F Gagel Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX, USA

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Bruce G Robinson Northern Clinical School, Kolling Institute of Medical Research, The University of Sydney School of Medicine, Sydney, Australia

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Kenna R Shaw Khalifa Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX

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Mimi I Hu Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX, USA

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avenues for clinical trials in MTC. Role of ATF4 in the pathogenesis of MTC Cancer cells are often exposed to nutrient starvation, hypoxia, oxidative stress and other metabolic dysregulation. These various stress factors can interfere with correct

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0110
Volume/Issue:
Volume 27: Issue 8
Free access
Yu Zhang Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China
Department of Pharmacy, Pulmonary Hospital of Wuhan, Wuhan, China
Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China

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Li Ma Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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Shuguang Dong Department of Cardiology, Tongren Hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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Qiaoyan Ding Department of Pharmacy, Pulmonary Hospital of Wuhan, Wuhan, China

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Shuman Wang Department of Pharmacy, Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine

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Qi Wu Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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Ping Ni Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China

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Hong Zhang Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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Yonggang Chen Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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Jinhu Wu Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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Xiong Wang Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China

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.01, P < 0.01, P < 0.05, P < 0.05, and P < 0.05, respectively) ( Fig. 6C and E-M ). Discussion The current theory on prolactinoma pathogenesis includes the effects of endocrine hormone, abnormal expression of genes, and irregular

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0168
Volume/Issue:
Volume 29: Issue 12
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Sarah A Dabydeen Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA

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Priscilla A Furth Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA
Departments of Oncology, Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Research Building, Room 520A, Washington, District of Columbia 20057, USA

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result in increased proliferation of the mammary ductal epithelium, leading to cancer progression. Creation of immortalized ER+ breast cancer cell lines was an important step for the experimental study of ER+ breast cancer pathogenesis and therapy in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0512
Volume/Issue:
Volume 21: Issue 3
Free access
Ines Donangelo Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Song-Guang Ren Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Tamar Eigler Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Clive Svendsen Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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Shlomo Melmed Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,

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pathogenesis of pituitary adenomas, no current general mechanism for pituitary tumor initiation is tenable. The tumor stem cell hypothesis represents an attractive unifying theory and postulates that deregulation of a small subpopulation of tumor cells

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0229
Volume/Issue:
Volume 21: Issue 2
Free access
M A Marcello
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P Malandrino Laboratory of Cancer Molecular Genetics (Gemoca), Endocrinology, Faculty of Medical Sciences, University of Campinas (FCM‐Unicamp), Rua Tessalia Vieira de Camargo, 126, Barao Geraldo, Campinas, Sao Paulo, 13083-887, Brazil

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J F M Almeida
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M B Martins
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L L Cunha
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N E Bufalo
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G Pellegriti Laboratory of Cancer Molecular Genetics (Gemoca), Endocrinology, Faculty of Medical Sciences, University of Campinas (FCM‐Unicamp), Rua Tessalia Vieira de Camargo, 126, Barao Geraldo, Campinas, Sao Paulo, 13083-887, Brazil

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L S Ward
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1575 – 1583 . ( doi:10.1093/jnci/djp354 ). Pipas JM 1992 Common and unique features of T antigens encoded by the polyomavirus group . Journal of Virology 66 3979 – 3985 . Raab-Traub N 2002 Epstein–Barr virus in the pathogenesis of NPC

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0131
Volume/Issue:
Volume 21: Issue 5
Free access
Samuel M O'Toole Department of Endocrinology, Hereditary Endocrine Cancer Group, Section on Endocrinology and Genetics, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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Judit Dénes Department of Endocrinology, Hereditary Endocrine Cancer Group, Section on Endocrinology and Genetics, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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Mercedes Robledo Department of Endocrinology, Hereditary Endocrine Cancer Group, Section on Endocrinology and Genetics, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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Constantine A Stratakis Department of Endocrinology, Hereditary Endocrine Cancer Group, Section on Endocrinology and Genetics, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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Márta Korbonits Department of Endocrinology, Hereditary Endocrine Cancer Group, Section on Endocrinology and Genetics, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK

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the same patient may be either entirely coincidental or a result of a common pathogenesis. Possible explanations include: a phaeo/PGL-predisposing mutation also causing PAs; a PA-predisposing mutation also causing phaeo/PGL; mutations in two different

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0241
Volume/Issue:
Volume 22: Issue 4
Free access
Paola Caria Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Tinuccia Dettori Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Daniela V Frau Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Angela Borghero Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Antonello Cappai Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Alessia Riola Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Maria L Lai Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Francesco Boi Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Piergiorgio Calò Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Angelo Nicolosi Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Stefano Mariotti Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Roberta Vanni Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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roles in the pathogenesis of most PTCs ( Santoro et al . 2006 , Xing 2007 ). Consequently, the use of some of these abnormalities as tumor biomarkers is being translated into clinical practice, and their preoperative examination is increasingly being

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0157
Volume/Issue:
Volume 20: Issue 4
Free access
Robert C Smallridge Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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Laura A Marlow Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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John A Copland Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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). Anaplastic thyroid carcinomas (ATCs) are estimated to comprise 1–2% of thyroid malignancies. Unfortunately, their rapid onset and fulminant course have not altered their detection or outcomes. This review will analyze their molecular pathogenesis, the results

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0154
Volume/Issue:
Volume 16: Issue 1
Free access
Deniz M Özata Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Stefano Caramuta Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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David Velázquez-Fernández Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Pinar Akçakaya Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Hong Xie Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Anders Höög Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Martin Bäckdahl Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Catharina Larsson Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Weng-Onn Lui Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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-PCR methodology. Taken together, the observations indicate the significant importance of these miRNAs in the pathogenesis of ACC. We showed that miR-497 expression is significantly reduced in ACC compared with adenomas. In concordance with our results, miR-497

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0082
Volume/Issue:
Volume 18: Issue 6
Open access
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P L M Dahia
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A B Grossman
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Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.0.0204267
Volume/Issue:
Volume 2: Issue 4
Restricted access