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Samuel M O’Toole William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK

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David S Watson William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Tatiana V Novoselova William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Lisa E L Romano William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Peter J King William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Teisha Y Bradshaw William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Clare L Thompson Institute of Bioengineering and School of Engineering and Material Sciences, Queen Mary University of London, London, UK

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Martin M Knight Institute of Bioengineering and School of Engineering and Material Sciences, Queen Mary University of London, London, UK

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Tyson V Sharp Barts Cancer Institute, Queen Mary University of London, London, UK

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Michael R Barnes William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Umasuthan Srirangalingam William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
Department of Diabetes and Endocrinology, University College London Hospital, London, UK

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William M Drake Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK

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J Paul Chapple William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK

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Introduction Pheochromocytomas (PCCs) are neuroendocrine tumors that originate from chromaffin cells of the adrenal medulla or autonomic nervous system, where they are termed paragangliomas (PGLs). The majority of the morbidity associated with

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Ali S Alzahrani Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Meshael Alswailem Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Alexandre Buffet Université Paris Cité, Inserm, Paris Centre de Recherche Cardiovasculaire (PARCC), Equipe Labellisée Ligue contre le Cancer, Paris, France
Département de Médecine Génomique des Tumeurs et des Cancers, Fédération de Génétique et de Médecine Génomique, Assistance Publique-Hôpitaux de Paris (AP-HP) Centre, Hôpital Européen Georges Pompidou, Paris, France

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Balgees Alghamdi Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Lulu Alobaid Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Osamah Alsagheir Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Hindi Al-Hindi Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Introduction Pheochromocytomas (PCCs) and paragangliomas (PGLs, abbreviated together as PPGLs) are rare neuroendocrine tumors of the adrenal medulla and the peripheral autonomic ganglia, respectively ( Lenders 2014 ). They arise from

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Marta Araujo-Castro Neuroendocrinology Unit, Department of Endocrinology and Nutrition
Department of Health Science, Universidad de Alcalá, Madrid, Spain

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Rogelio Garcia Centeno Department of Endocrinology & Nutrition, Hospital Universitario Gregorio Marañón, Madrid, Spain

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María-Carmen López-García Department of Endocrinology & Nutrition, Hospital Universitario de Albacete, Albacete, Spain

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Cristina Lamas Department of Endocrinology & Nutrition, Hospital Universitario de Albacete, Albacete, Spain

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Cristina Álvarez-Escolá Department of Endocrinology & Nutrition, Hospital Universitario La Paz, Madrid, Spain

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María Calatayud Gutiérrez Department of Endocrinology & Nutrition, Hospital Universitario Doce de Octubre, Madrid, Spain

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Concepción Blanco-Carrera Department of Endocrinology & Nutrition, Hospital Universitario Príncipe de Asturias, Madrid, Spain

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Paz de Miguel Novoa Department of Endocrinology & Nutrition, Hospital Universitario Clínico San Carlos, Madrid, Spain

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Nuria Valdés Department of Endocrinology & Nutrition, Hospital Universitario de Cabueñes, Asturias, Spain

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Paola Gracia Gimeno Department of Endocrinology & Nutrition, Hospital Royo Villanova, Zaragoza, Spain

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Mariana Tomé Fernández-Ladreda Department of Endocrinology & Nutrition, Hospital Universitario de Puerto Real, Cádiz, Spain

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César Mínguez Ojeda Department of Urology, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Juan Carlos Percovich Hualpa Department of Endocrinology & Nutrition, Hospital Universitario Gregorio Marañón, Madrid, Spain

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Mireia Mora Department of Endocrinology & Nutrition, Hospital Clinic, Barcelona, Spain
Group of Endocrine Disorders, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

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Óscar Vidal Department of General Surgery, Hospital Clinic, Barcelona, Spain

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Ana Serrano Romero Department of Anesthesia, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Felicia Alexandra Hanzu Department of Endocrinology & Nutrition, Hospital Clinic, Barcelona, Spain
Group of Endocrine Disorders, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

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Victoria Gómez Dos Santos Department of Urology, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Introduction Pheochromocytomas are rare neuroendocrine tumours that produce catecholamines ( Lenders et al. 2014 ). Anaesthetic induction and surgical manipulation of the tumour can precipitate the release of an excessive amount of

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Birke Bausch
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Ulrich Wellner 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Dirk Bausch 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Francesca Schiavi 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Marta Barontini 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Gabriela Sanso 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Martin K Walz 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Mariola Peczkowska 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Georges Weryha 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Patrizia Dall'Igna 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Giovanni Cecchetto 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Gianni Bisogno 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Lars C Moeller 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Detlef Bockenhauer 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Attila Patocs 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Karoly Rácz 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Dmitry Zabolotnyi 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Svetlana Yaremchuk 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Iveta Dzivite-Krisane 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Frederic Castinetti 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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David Taieb 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Angelica Malinoc 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Ernst von Dobschuetz 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Jochen Roessler 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Kurt W Schmid 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Giuseppe Opocher 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Charis Eng 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Hartmut P H Neumann 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Introduction Pheochromocytomas and paragangliomas are tumors of the overall paraganglial system, mainly the adrenal glands, the retroperitoneum, the pelvis, the thorax, and the skullbase and neck regions ( Neumann 2008 ). Such paraganglial tumors

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Katherine I Wolf Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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Linda Rose-Krasnor Pheo Para Alliance and Psychology Department, Brock University, St. Catharines, Ontario, Canada

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Stephanie Alband Pheo Para Alliance, Alexandria, Virginia, USA

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Jacques W M Lenders Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Lauren Fishbein Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, and Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Introduction Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin-cell tumors from the adrenal medulla and the sympathetic paravertebral ganglia of the thorax, abdomen, and pelvis, as well as along the parasympathetic ganglia at

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Jacques Amar Department of Arterial Hypertension, Toulouse University, Hôpital Rangueil, Toulouse, France
INSERM UMR1048, I2MC, Toulouse, France

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Jeremy Brunel Department of Arterial Hypertension, Toulouse University, Hôpital Rangueil, Toulouse, France

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Catherine Cardot Bauters Service d’Endocrinologie, Hôpital Claude Huriez, CHU Lille, Lille, France

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Virginie Jacques Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France
Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France

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Clément Delmas INSERM UMR1048, I2MC, Toulouse, France
Department of Cardiology Toulouse University, Hôpital Rangueil, Toulouse, France

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Marie-Françoise Odou Service de Biochimie et Biologie Moléculaire ‘Hormonologie, Métabolisme-Nutrition, Oncologie’, CHU Lille, Lille, France
Univ. Lille, Inserm, CHU Lille, U1286 – Infinite – Institute for Translational Research in Inflammation, Lille, France

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Frédérique Savagner Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France
Laboratory of Biochemistry and Molecular Biology, IFB-CHU, Toulouse, France

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Introduction Pheochromocytoma–paraganglioma (PPGL) are rare tumors ( Berends et al. 2018 ) that produce and store catecholamines. The release of excessive amounts of catecholamines can lead to life-threatening cardiovascular complications

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Douglas Wiseman National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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James D McDonald National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Dhaval Patel National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Electron Kebebew Stanford University School of Medicine, Stanford, California, USA

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Karel Pacak Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Naris Nilubol National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Introduction Pheochromocytomas and paragangliomas (PPGLs) are rare, catecholamine-secreting tumors arising from the chromaffin cells of the adrenal medulla and extra-adrenal neural crest tissues, which run from the skull base to the pelvis

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Trisha Dwight Cancer Genetics, Kolling Institute, Royal North Shore Hospital, Sydney, New South Wales, Australia
The University of Sydney, Sydney, New South Wales, Australia

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Aidan Flynn The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen N, Denmark
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen N, Denmark

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Kaushalya Amarasinghe The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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Diana E Benn Cancer Genetics, Kolling Institute, Royal North Shore Hospital, Sydney, New South Wales, Australia
The University of Sydney, Sydney, New South Wales, Australia

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Richard Lupat The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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Jason Li The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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Daniel L Cameron The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia

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Annette Hogg The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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Shiva Balachander The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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Ida L M Candiloro Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
The Department of Pathology, University of Melbourne, Parkville, Victoria, Australia

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Stephen Q Wong The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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Bruce G Robinson Cancer Genetics, Kolling Institute, Royal North Shore Hospital, Sydney, New South Wales, Australia
The University of Sydney, Sydney, New South Wales, Australia

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Anthony T Papenfuss The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia
The Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia

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Anthony J Gill The University of Sydney, Sydney, New South Wales, Australia
Cancer Diagnosis and Pathology Group, Kolling Institute, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Alexander Dobrovic Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
The Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia

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Rodney J Hicks The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

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Roderick J Clifton-Bligh Cancer Genetics, Kolling Institute, Royal North Shore Hospital, Sydney, New South Wales, Australia
The University of Sydney, Sydney, New South Wales, Australia

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Richard W Tothill The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
The Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

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Introduction Pheochromocytomas (PC) and paragangliomas (PGLs) are neuroendocrine tumors derived from neural crest cells of the sympathetic and parasympathetic nervous system – PCs arising in the adrenal medulla and PGLs in paraganglia outside

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Atanaska Elenkova Department of Endocrinology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria
Expert Center for Rare Endocrine Diseases, Sofia, Bulgaria
European Network on Rare Endocrine Conditions (ENDO-ERN)

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Rabhat Shabani Alexandrovska Hospital, Medical University – Sofia, Sofia, Bulgaria

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Elena Kinova University Hospital ‘Queen Joanna’, Medical University – Sofia, Sofia, Bulgaria

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Vladimir Vasilev Department of Endocrinology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria
Expert Center for Rare Endocrine Diseases, Sofia, Bulgaria
European Network on Rare Endocrine Conditions (ENDO-ERN)

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Assen Goudev University Hospital ‘Queen Joanna’, Medical University – Sofia, Sofia, Bulgaria

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Sabina Zacharieva Department of Endocrinology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria
Expert Center for Rare Endocrine Diseases, Sofia, Bulgaria
European Network on Rare Endocrine Conditions (ENDO-ERN)

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Introduction Cardiovascular disturbances are the major clinical manifestations of pheochromocytoma. Arterial hypertension is the leading symptom in approximately 90% of all patients, usually with a paroxysmal course, severe, malignant or

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Camilo Jimenez University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Bennett B Chin University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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Richard B Noto Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

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Joseph S Dillon University of Iowa, Iowa City, Iowa, USA

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Lilja Solnes Johns Hopkins Medicine, Baltimore, Maryland, USA

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Nancy Stambler Progenics Pharmaceuticals, Inc., a Lantheus Company, North Billerica, Massachusetts, USA

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Vincent A DiPippo Progenics Pharmaceuticals, Inc., a Lantheus Company, North Billerica, Massachusetts, USA

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Daniel A Pryma Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Introduction Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and paraganglia, respectively ( Jimenez 2018 ). Each year, approximately 500–1600 new cases of PPGLs

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