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Katharina Lampichler
Katharina Lampichler
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Patricio Ferrer
Patricio Ferrer
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Greisa Vila
Greisa Vila
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Mirjam I Lutz
Mirjam I Lutz
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Florian Wolf
Florian Wolf
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Engelbert Knosp
Engelbert Knosp
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Ludwig Wagner
Ludwig Wagner
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Anton Luger
Anton Luger
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Sabina Baumgartner-Parzer
Sabina Baumgartner-Parzer
Division of Endocrinology and Metabolism, Clinical Institute of Neurology, Department of Biomedical Imaging and Image‐Guided Therapy, Division of Neurosurgery, Division of Nephrology, Department of Internal Medicine III
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Introduction The anterior pituitary gland is a key regulator of the endocrine system. During the life-span it undergoes extensive remodeling responding to metabolic changes and is therefore prone to tumor formation. Pituitary adenomas are the most
R Formosa
R Formosa
Department of Medicine, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
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J Borg
J Borg
Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida, Malta
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J Vassallo
J Vassallo
Department of Medicine, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Department of Medicine, Neuroendocrine Clinic, Mater Dei Hospital, Msida, Malta
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Department of Medicine, Neuroendocrine Clinic, Mater Dei Hospital, Msida, Malta
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Introduction Pituitary adenomas (PA) represent the commonest cranial neoplasms and vary in size, type and aggressiveness. Clinically relevant PAs result in symptoms due to hormonal hypersecretion, intracranial mass effects or secondary
Eric Monsalves
Eric Monsalves
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Kyle Juraschka
Kyle Juraschka
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Toru Tateno
Toru Tateno
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Sameer Agnihotri
Sameer Agnihotri
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Sylvia L Asa
Sylvia L Asa
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Shereen Ezzat
Shereen Ezzat
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Gelareh Zadeh
Gelareh Zadeh
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Introduction Pituitary adenomas (PAs) are common intracranial neoplasms accounting for up to 25% of primary brain tumors ( Asa & Ezzat 2009 ). A large proportion of PAs are prolactinomas, although most macroadenomas are clinically nonfunctional
Thomas Cuny
Thomas Cuny
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
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Caroline Zeiller
Caroline Zeiller
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
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Martin Bidlingmaier
Martin Bidlingmaier
Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany
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Céline Défilles
Céline Défilles
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
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Catherine Roche
Catherine Roche
APHM, Conception, Laboratory of Molecular Biology, Marseille, France
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Marie-Pierre Blanchard
Marie-Pierre Blanchard
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
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Marily Theodoropoulou
Marily Theodoropoulou
Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany
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Thomas Graillon
Thomas Graillon
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM Timone, Department of Neurosurgery, Marseille, France
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APHM Timone, Department of Neurosurgery, Marseille, France
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Morgane Pertuit
Morgane Pertuit
APHM, Conception, Laboratory of Molecular Biology, Marseille, France
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Dominique Figarella-Branger
Dominique Figarella-Branger
APHM Timone, Laboratory of Neuropathology and Aix-Marseille University, INSERM, CRO2 UMR911, Marseille, France
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Alain Enjalbert
Alain Enjalbert
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM, Conception, Laboratory of Molecular Biology, Marseille, France
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APHM, Conception, Laboratory of Molecular Biology, Marseille, France
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Thierry Brue
Thierry Brue
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM Conception, Department of Endocrinology, Marseille, France
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APHM Conception, Department of Endocrinology, Marseille, France
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Anne Barlier
Anne Barlier
Aix-Marseille University, CNRS, CRN2M UMR7286, Marseille, France
APHM, Conception, Laboratory of Molecular Biology, Marseille, France
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APHM, Conception, Laboratory of Molecular Biology, Marseille, France
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secretion and cellular viability of both primary cultures of human GH-secreting pituitary adenomas and of the rat somatolactotroph GH4C1 cell line. Design and methods Patients This in vitro study included somatotroph tumors from patients
Francesca Branzoli
Francesca Branzoli
Paris Brain Institute - Institut du Cerveau (ICM), Center for Neuroimaging Research (CENIR), Paris, France
Sorbonne University, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, Paris, France
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Sorbonne University, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, Paris, France
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Betty Salgues
Betty Salgues
Sorbonne University, nuclear medicine department, Pitié-Salpêtrière Hospital, Assistance -Publique Hôpitaux de Paris, Paris, France
Paris Cardiovascular Research Center (PARCC), Inserm, Paris, France
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Paris Cardiovascular Research Center (PARCC), Inserm, Paris, France
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Małgorzata Marjańska
Małgorzata Marjańska
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA
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Marie Laloi-Michelin
Marie Laloi-Michelin
Endocrinology department, Lariboisière Hospital, Assistance -Publique Hôpitaux de Paris, Paris, France
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Philippe Herman
Philippe Herman
ENT unit, Lariboisière Hospital, Assistance -Publique Hôpitaux de Paris, Paris-Cité University, INSERM U1141, Paris, France
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Lauriane Le Collen
Lauriane Le Collen
Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, EGID, University of Lille, Lille, France
Department of Endocrinology Diabetology, University Hospital Center of Reims, Reims, France
Department of Genetic, University Hospital Center of Reims, Reims, France
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Department of Endocrinology Diabetology, University Hospital Center of Reims, Reims, France
Department of Genetic, University Hospital Center of Reims, Reims, France
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Brigitte Delemer
Brigitte Delemer
Department of Endocrinology Diabetology, University Hospital Center of Reims, Reims, France
CRESTIC EA 3804, University of Reims Champagne Ardenne, UFR Sciences Exactes et Naturelles, Moulin de La Housse, BP 1039, Reims, France
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CRESTIC EA 3804, University of Reims Champagne Ardenne, UFR Sciences Exactes et Naturelles, Moulin de La Housse, BP 1039, Reims, France
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Julien Riancho
Julien Riancho
AP-HP, Hôpital Européen Georges Pompidou, Hypertension Unit, and Reference centre for rare adrenal diseases, Paris, France
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Emmanuelle Kuhn
Emmanuelle Kuhn
Pituitary Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France
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Christel Jublanc
Christel Jublanc
Pituitary Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France
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Nelly Burnichon
Nelly Burnichon
Département de médecine génomique des tumeurs et des cancers, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France
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Université Paris Cité, Inserm, PARCC, Paris, France
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Laurence Amar
Laurence Amar
AP-HP, Hôpital Européen Georges Pompidou, Hypertension Unit, and Reference centre for rare adrenal diseases, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France
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Université Paris Cité, Inserm, PARCC, Paris, France
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Judith Favier
Judith Favier
Université Paris Cité, Inserm, PARCC, Paris, France
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Anne-Paule Gimenez-Roqueplo
Anne-Paule Gimenez-Roqueplo
Département de médecine génomique des tumeurs et des cancers, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France
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Université Paris Cité, Inserm, PARCC, Paris, France
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Alexandre Buffet
Alexandre Buffet
Département de médecine génomique des tumeurs et des cancers, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France
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Université Paris Cité, Inserm, PARCC, Paris, France
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Charlotte Lussey-Lepoutre
Charlotte Lussey-Lepoutre
Sorbonne University, nuclear medicine department, Pitié-Salpêtrière Hospital, Assistance -Publique Hôpitaux de Paris, Paris, France
Paris Cardiovascular Research Center (PARCC), Inserm, Paris, France
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Paris Cardiovascular Research Center (PARCC), Inserm, Paris, France
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Introduction Pituitary adenomas (PAs) are benign tumors and are most frequently sporadic, with inheritance in approximately 5% of cases. The most common familial syndromes predisposing to PAs are familial isolated pituitary adenomas, multiple
Vladimir Vasilev
Vladimir Vasilev
Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium
Department of Endocrinology, Medical University, Sofia, Bulgaria
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Department of Endocrinology, Medical University, Sofia, Bulgaria
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Adrian F Daly
Adrian F Daly
Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium
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Giampaolo Trivellin
Giampaolo Trivellin
Section on Endocrinology and Genetics Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) National Institutes of Health (NIH), Bethesda, Maryland, USA
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Constantine A Stratakis
Constantine A Stratakis
Section on Endocrinology and Genetics Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) National Institutes of Health (NIH), Bethesda, Maryland, USA
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Sabina Zacharieva
Sabina Zacharieva
Department of Endocrinology, Medical University, Sofia, Bulgaria
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Albert Beckers
Albert Beckers
Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium
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Introduction Pituitary adenomas are intracranial tumors that occur in 10–15% of individuals in autopsy series and in 20–38% of those undergoing CT/MRI ( Ezzat et al . 2004 , Molitch 2009 , Freda et al . 2011 ). The vast majority of these
Kari Hemminki
Kari Hemminki
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Asta Försti
Asta Försti
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Jianguang Ji
Jianguang Ji
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Introduction Pituitary adenomas are indolent tumors, which account for 10–15% of all diagnosed intracranial neoplasms ( Asa & Ezzat 2002 , DeLellis et al. 2004 ). Small adenomas may occur in up to 15% of pituitary glands examined
Robert C Fowkes
Robert C Fowkes
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George Vlotides
George Vlotides
Endocrine Signalling Group, Department of Internal Medicine II, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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pituitary tumors reported by Kim et al . (2005) and the observed anti-apoptotic actions by HIF1α in a human pituitary adenoma cell line (HP-75; Yoshida et al . 2006 ) could suggest a VEGF-independent HIF1α-mediated regulation of pituitary tumor growth
Annamaria Colao
Annamaria Colao
Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy
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Carolina Di Somma
Carolina Di Somma
Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy
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Rosario Pivonello
Rosario Pivonello
Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy
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Antongiulio Faggiano
Antongiulio Faggiano
Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy
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Gaetano Lombardi
Gaetano Lombardi
Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy
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Silvia Savastano
Silvia Savastano
Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy
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Introduction Non-functioning pituitary adenomas (NFAs) represent a very heterogeneous group of tumours, accounting for 25% of all pituitary adenomas ( Katznelson et al . 1993 ). They often present with macroadenomas that cause neurological symptoms
Ines Donangelo
Ines Donangelo
Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,
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Song-Guang Ren
Song-Guang Ren
Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,
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Tamar Eigler
Tamar Eigler
Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,
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Clive Svendsen
Clive Svendsen
Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,
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Shlomo Melmed
Shlomo Melmed
Pituitary Center, Regenerative Medicine Institute, Cedars‐Sinai Medical Center,
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). However, precisely how pituitary adenomas develop and progress and the molecular bases of their unique features are poorly understood. Stem cells are unspecialized cells with the ability to self-renew (ability to go through numerous cycles of cell division
