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Chiara Villa Department of Neuropathology, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France
Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France

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Bertrand Baussart Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Neurosurgery, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France

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Guillaume Assié Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin APHP, Paris, France

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Gerald Raverot Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, Bron, France
Lyon 1 University, Villeurbanne, France
Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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WHO 2004 ENDO4 WHO 2017 CNS5 WHO 2021 ENDO5 WHO 2022 Nomenclature Typical adenoma Adenoma ( Subtype ) Pituitary adenoma / pituitary neuroendocrine tumour (PitNET) ( Subtype ) Pituitary

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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience and Experimental Psychology, School of Medicine, Manchester University, Manchester, UK

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Estelle Healy Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Madhu Basetti Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ruth T Casey Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Introduction Primary tumours of adenohypophyseal cells recently suggested to be redefined as pituitary neuroendocrine tumours (PitNETs) can rarely occur in association with paraganglioma (PGL) or phaeochromocytoma. These tumours may develop in

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Pedro Marques Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Sayka Barry Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Eivind Carlsen Department of Pathology, STHF, Skien, Norway

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David Collier Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Amy Ronaldson Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Sherine Awad Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Neil Dorward The National Hospital for Neurology and Neurosurgery, UCLH, NHS Trust, London, UK

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Joan Grieve The National Hospital for Neurology and Neurosurgery, UCLH, NHS Trust, London, UK

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Nigel Mendoza Department of Neurosurgery, Charing Cross Hospital, Imperial College, London, UK

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Samiul Muquit Department of Neurosurgery, Derriford Hospital, Plymouth, UK

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Ashley B Grossman Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Frances Balkwill Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Introduction The great majority of pituitary neuroendocrine tumours (PitNETs) are benign, although they can cause significant burden to patients due to mass effects, invasion and/or due to excessive or low hormone secretion ( Di Ieva et al

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Maria P Yavropoulou Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Marina Tsoli Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Konstantinos Barkas Department of Neurosurgery, General Hospital of Nikaia-Peiraia, Agios Panteleimon, Athens, Greece

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Gregory Kaltsas Endocrinοlogy Unit, 1st Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Ashley Grossman Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

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incidentally diagnosed during imaging investigations performed for unrelated purposes (pituitary incidentalomas, PIs) ( Scangas & Laws 2014 ). Recently, pituitary adenomas have been suggested to be renamed pituitary neuroendocrine tumours (pitNETs) ( Asa et al

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Judith Favier Université Paris Cité, Inserm UMR970 PARCC, Equipe Labellisée par la Ligue contre le cancer, Paris, France

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Roderick Clifton-Bligh Department of Endocrinology Royal North Shore Hospital, University of Sydney, Sydney, Australia

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Casey RT Hunter SJ & Korbonits M 2022 Succinate dehydrogenas e and MYC-associated factor X mutations in pituitary neuroendocrine tumours . Endocrine-Related Cancer 29 R157 – R172 . ( https://doi.org/10.1530/ERC-22-0157 ) Pacak K & Clifton

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Mirela Diana Ilie Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Endocrinology Department, ‘C.I. Parhon’ National Institute of Endocrinology, Bucharest, Romania

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Alexandre Vasiljevic Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Pathology Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France

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Emmanuel Jouanneau Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Neurosurgery Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France

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Gérald Raverot Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France

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Chiloiro S Carlsen E Bianchi A Giampietro A Tartaglione T Bima C Bracaccia ME Lugli F Lauretti L , 2020 Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours . Endocrine 67 651 – 658 . ( https

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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Brian Herron Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Stephen Cooke Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Jayna Elizabeth Smyth Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Karen R Mullan Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Estelle G Healy Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Jane Evanson Department of Radiology, Barts Health NHS Trust, London, UK

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Stephanie G Craig Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK

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Jacqueline A James Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK
Northern Ireland Biobank, Belfast Health and Social Care Trust, Belfast, UK

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Márta Korbonits Department of Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Introduction Cushing’s disease (CD) is a rare condition of endogenous hypercortisolaemia resulting from an adrenocorticotrophin (ACTH)-secreting pituitary neuroendocrine tumour. Annual incidence of CD has been estimated at 1.2–1.8 cases per

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Dorota Dworakowska Department of Hypertension and Diabetes, Medical University of Gdańsk, Gdańsk, Poland
Guys Richard Dimbleby Department of Cancer Research, Kings College London, London, UK
Endocard LTD, London, UK

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Ashley B Grossman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Centre for Endocrinology, William Harvey Institute, Barts and the London School of Medicine, London, UK

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World Health Organization (WHO) classification ( Osamura et al. 2017 a , b ), and even suggestions that we abandon the term ‘pituitary adenoma’ entirely in terms of these all being pituitary neuroendocrine tumours (PitNETs) ( Asa et al. 2017

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Francesca Branzoli Paris Brain Institute - Institut du Cerveau (ICM), Center for Neuroimaging Research (CENIR), Paris, France
Sorbonne University, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, Paris, France

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Betty Salgues Sorbonne University, nuclear medicine department, Pitié-Salpêtrière Hospital, Assistance -Publique Hôpitaux de Paris, Paris, France
Paris Cardiovascular Research Center (PARCC), Inserm, Paris, France

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Małgorzata Marjańska Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA

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Marie Laloi-Michelin Endocrinology department, Lariboisière Hospital, Assistance -Publique Hôpitaux de Paris, Paris, France

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Philippe Herman ENT unit, Lariboisière Hospital, Assistance -Publique Hôpitaux de Paris, Paris-Cité University, INSERM U1141, Paris, France

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Lauriane Le Collen Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, EGID, University of Lille, Lille, France
Department of Endocrinology Diabetology, University Hospital Center of Reims, Reims, France
Department of Genetic, University Hospital Center of Reims, Reims, France

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Brigitte Delemer Department of Endocrinology Diabetology, University Hospital Center of Reims, Reims, France
CRESTIC EA 3804, University of Reims Champagne Ardenne, UFR Sciences Exactes et Naturelles, Moulin de La Housse, BP 1039, Reims, France

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Julien Riancho AP-HP, Hôpital Européen Georges Pompidou, Hypertension Unit, and Reference centre for rare adrenal diseases, Paris, France

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Emmanuelle Kuhn Pituitary Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Christel Jublanc Pituitary Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France

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Nelly Burnichon Département de médecine génomique des tumeurs et des cancers, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France

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Laurence Amar AP-HP, Hôpital Européen Georges Pompidou, Hypertension Unit, and Reference centre for rare adrenal diseases, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France

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Judith Favier Université Paris Cité, Inserm, PARCC, Paris, France

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Anne-Paule Gimenez-Roqueplo Département de médecine génomique des tumeurs et des cancers, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France

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Alexandre Buffet Département de médecine génomique des tumeurs et des cancers, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Cité, Inserm, PARCC, Paris, France

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Charlotte Lussey-Lepoutre Sorbonne University, nuclear medicine department, Pitié-Salpêtrière Hospital, Assistance -Publique Hôpitaux de Paris, Paris, France
Paris Cardiovascular Research Center (PARCC), Inserm, Paris, France

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neuroendocrine tumours . Endocrine-Related Cancer 29 R157 – R172 . ( https://doi.org/10.1530/ERC-22-0157 ) Lussey-Lepoutre C Bellucci A Burnichon N Amar L Buffet A Drossart T Fontaine S Clement O Benit P Rustin P 2020 Succinate detection

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Audrey Ziverec Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Marie Chanal Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Perrine Raymond Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Mirela Diana Ilie Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France
Endocrinology Department, “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania

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Dario De Alcubierre Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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Arja Pasternack Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Olli Ritvos Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Gerald Raverot Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France
Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
Department of Endocrinology, Reference center for rare pituitary disease (HYPO), Groupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France

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Philippe Bertolino Cancer Research Centre of Lyon (CRCL), INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France

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microenvironment in pituitary neuroendocrine tumours . Acta Neuropathologica Communications 7 172. ( https://doi.org/10.1186/s40478-019-0830-3 ) Marques P Barry S Carlsen E Collier D Ronaldson A Dorward N Grieve J Mendoza N Nair R Muquit S

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