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Section on Endocrinology and Genetics, Group for Advanced Molecular Investigation, Department of Pharmacology and Therapeutics, Pediatric Endocrinology Inter-institute Training Program, The Liggins Institute, Taranaki Base Hospital, Auckland City Hospital & Greenlane Clinical Centre, Department of Neurosurgery, Surgical Neurology Branch, Endocrinology and Metabolic Disorders, Pediatrics, Program on Developmental Endocrinology and Genetics (PDEGEN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland 20892, USA
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Section on Endocrinology and Genetics, Group for Advanced Molecular Investigation, Department of Pharmacology and Therapeutics, Pediatric Endocrinology Inter-institute Training Program, The Liggins Institute, Taranaki Base Hospital, Auckland City Hospital & Greenlane Clinical Centre, Department of Neurosurgery, Surgical Neurology Branch, Endocrinology and Metabolic Disorders, Pediatrics, Program on Developmental Endocrinology and Genetics (PDEGEN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland 20892, USA
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Section on Endocrinology and Genetics, Group for Advanced Molecular Investigation, Department of Pharmacology and Therapeutics, Pediatric Endocrinology Inter-institute Training Program, The Liggins Institute, Taranaki Base Hospital, Auckland City Hospital & Greenlane Clinical Centre, Department of Neurosurgery, Surgical Neurology Branch, Endocrinology and Metabolic Disorders, Pediatrics, Program on Developmental Endocrinology and Genetics (PDEGEN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland 20892, USA
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Section on Endocrinology and Genetics, Group for Advanced Molecular Investigation, Department of Pharmacology and Therapeutics, Pediatric Endocrinology Inter-institute Training Program, The Liggins Institute, Taranaki Base Hospital, Auckland City Hospital & Greenlane Clinical Centre, Department of Neurosurgery, Surgical Neurology Branch, Endocrinology and Metabolic Disorders, Pediatrics, Program on Developmental Endocrinology and Genetics (PDEGEN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland 20892, USA
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Section on Endocrinology and Genetics, Group for Advanced Molecular Investigation, Department of Pharmacology and Therapeutics, Pediatric Endocrinology Inter-institute Training Program, The Liggins Institute, Taranaki Base Hospital, Auckland City Hospital & Greenlane Clinical Centre, Department of Neurosurgery, Surgical Neurology Branch, Endocrinology and Metabolic Disorders, Pediatrics, Program on Developmental Endocrinology and Genetics (PDEGEN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland 20892, USA
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-producing adenomas. Although our data do not prove a definitive link between pituitary tumor formation and IGSF1 , the variation in its pituitary expression and the high number of polymorphisms suggests that IGSF1 should be studied further as a possible modifier
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PhD Program in Endocrinological Sciences, Sapienza University of Rome, Rome, Italy
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Introduction Pituitary tumors, accounting for 16.2% of all primary brain and other central nervous system tumors ( Ostrom et al. 2017 ), are classified based on their secretory activity in non-functioning pituitary tumors (NFPTs) or hormone
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Endocrine Genetics Unit LIM-25, Neuroendocrinology Unit, Adrenal Unit (LIM-42), Experimental Oncology Laboratory (LIM-24), Nursing School, School of Public Health, Endocrinology Division, Brigadeiro Hospital, Federal University of Sao Paulo, Human Genome Research Center, Department of Cell and Developmental Biology, Instituto do Cérebro, National Institute of Aging, Institute of Pathology, School of Medicine, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
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Endocrine Genetics Unit LIM-25, Neuroendocrinology Unit, Adrenal Unit (LIM-42), Experimental Oncology Laboratory (LIM-24), Nursing School, School of Public Health, Endocrinology Division, Brigadeiro Hospital, Federal University of Sao Paulo, Human Genome Research Center, Department of Cell and Developmental Biology, Instituto do Cérebro, National Institute of Aging, Institute of Pathology, School of Medicine, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
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reported for the European/HapMap-CEU population (G=0.56 and T=0.44) than to those found in African/HapMap-YRI populations (G=0.75 and T=0.25). The role of p27-V109G specifically in ACTH–pituitary tumors Protection by the G allele (GT and GG genotypes) was
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Department of Imaging and Pathology, UZ Leuven (University Hospitals Leuven), Leuven, Belgium
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Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, Yamagata, Japan
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prevalent, being detected in 15–25% of the general population, with serious clinical symptoms in 0.1% ( Ezzat et al. 2004 , Daly et al. 2009 , Mete & Lopes 2017 , Melmed 2020 ). Although pituitary tumors mainly represent benign and slow
Endocrinology Department, ‘C.I. Parhon’ National Institute of Endocrinology, Bucharest, Romania
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Pathology Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France
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Neurosurgery Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France
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Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France
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Introduction Anterior pituitary tumors are usually benign neoplasms that derive from the endocrine cells of the anterior pituitary gland. However, a small percentage of them have an aggressive behavior, showing resistance and/or multiple
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et al . 2002 , Byun et al . 2003 , Samuels et al . 2004 , Wu et al . 2005 , Kozaki et al . 2006 ). Pituitary tumors are common endocrine neoplastic diseases. Multiple tumor-promoting factors or signaling pathways are known to be involved
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Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Introduction Considerable progress has been achieved in identifying mechanisms/factors that are involved in pituitary tumor initiation and progression ( Dworakowska & Grossman 2012 , Perez-Castro et al . 2012 , Gatto et al . 2013
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the receptor HER2) has been the first to attain clinical use, mainly for the treatment of metastatic breast cancer ( Baselga et al . 1996 , Cobleigh et al . 1999 ). The expression of HER2 has been reported in pituitary tumors ( Ezzat et al . 1997
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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Introduction Pituitary tumors are generally benign adenomas. Radiology and autopsy, being performed for reasons other than pituitary-related medical ones, show a high prevalence of 10–15% in the overall population, although most of these lesions are
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are rare and account for approximately 0.12% of PAs in the German Pituitary Tumor Registry ( Saeger et al . 2007 ). Its etiology is not clear and two possible mechanisms have been proposed: (i) step-wise transformation from an adenoma to an invasive