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Takuya Mikoshiba Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Mariko Sekimizu Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Shin Saito Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Shintaro Nakamura Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Ryoto Nagai Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Miho Kawaida Division of Diagnostic Pathology, Keio University Hospital, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Isao Kurihara Division of Medical Education Improvement and Planning, Medical Education and Clinical Training Center, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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Sakiko Kobayashi Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
Department of Endocrinology, Metabolism and Nephrology, NHO Tokyo Medical Center, Higashigaoka, Meguro-ku, Tokyo, Japan

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Hiroyuki Ozawa Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan

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& Azcutia 2019 , Zhou et al. 2019 , Chung et al. 2020 , Abe et al. 2021 ). Most are described in the form of case reports, and only a few reports reviewed many cases ( Kunc et al. 2015 ). Therefore, its prevalence has not yet been clarified

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0030
Volume/Issue:
Volume 31: Issue 9
Restricted access
Arivarasan Karunamurthy Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Federica Panebianco Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Susan J Hsiao Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Jennie Vorhauer Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Simion Chiosea Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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also reported EIF1AX mutations in anaplastic thyroid carcinomas (ATC) ( Kunstman et al. 2015 ). However, the prevalence of these mutations in other common types of thyroid cancer, such as follicular carcinoma, and in benign thyroid nodules remains

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0043
Volume/Issue:
Volume 23: Issue 4
Free access
Jes Sloth Mathiesen Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Jens Peter Kroustrup Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Peter Vestergaard Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Mette Madsen Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark

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Kirstine Stochholm Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark

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Per Løgstrup Poulsen Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark

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Sten Schytte Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Henrik Baymler Pedersen Department of ORL Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark

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Christoffer Holst Hahn Department of ORL Head & Neck Surgery, Copenhagen University Hospital, Copenhagen, Denmark

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Jens Bentzen Department of Oncology, Herlev Hospital, Herlev, Denmark

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Mette Gaustadnes Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Torben Falck Ørntoft Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Thomas van Overeem Hansen Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Finn Cilius Nielsen Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Kim Brixen Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Anja Lisbeth Frederiksen Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

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Christian Godballe Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark

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alive at April 21, 2012, yielding a point prevalence of 1.65 per million ( Znaczko et al . 2014 ). However, it is unclear if this is representative of larger populations. A German study reported an MEN2B incidence (M918T carriers only) of 1.4 per

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-17-0122
Volume/Issue:
Volume 24: Issue 7
Free access
Stefan Zoltán Lutz Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

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Tilman Todenhöfer Department of Urology, University of Tübingen, Tübingen, Germany

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Robert Wagner Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

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Jörg Hennenlotter Department of Urology, University of Tübingen, Tübingen, Germany

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Jana Marlene Ferchl Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany

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Marcus Oliver Scharpf Institute of Pathology, University of Tübingen, Tübingen, Germany

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Peter Martus Institute of Clinical Epidemiology and applied Biostatistics, University of Tübingen, Tübingen, Germany

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Harald Staiger Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany

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Andreas Fritsche Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

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Arnulf Stenzl Department of Urology, University of Tübingen, Tübingen, Germany

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Hans-Ulrich Häring Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

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Martin Heni Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tübingen, Tübingen, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

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be higher in diabetes ( Giovannucci et al . 2010 ). However, studies reported that incidence of PCa is not increased in men with type 2 diabetes, some studies even found reduced prevalence ( Kasper et al . 2009 ). In contrast, PCa survival is

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-17-0465
Volume/Issue:
Volume 25: Issue 3
Free access
J Di Cristofaro
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V Vasko
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V Savchenko
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S Cherenko
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A Larin
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M D Ringel
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M Saji
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M Marcy
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J F Henry
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P Carayon
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C De Micco
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and Brest regions ( Prisyazhiuk et al. 1991 , Baverstock et al. 1992 ). In Belarus, the prevalence of pediatric cancer peaked in 1995 and thereafter decreased gradually while that of adolescent thyroid cancer increased ( Demidchik et al. 2002

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00884
Volume/Issue:
Volume 12: Issue 1
Free access
Seo Ki Kim Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jung-Woo Woo Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jun Ho Lee Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Inhye Park Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jung-Han Kim Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135‐710, South Korea

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thyroiditis; PTC, papillary thyroid carcinoma; ETE, extrathyroidal extension; CLNM, central lymph node metastasis. CLT was an independent predictor for low prevalence of ETE in both BRAF-negative and BRAF-positive conventional PTC patients As seen in Table 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0408
Volume/Issue:
Volume 23: Issue 1
Free access
L Fugazzola
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E Puxeddu
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N Avenia
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C Romei
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V Cirello
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A Cavaliere
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P Faviana
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D Mannavola
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S Moretti
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S Rossi
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M Sculli
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V Bottici
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P Beck-Peccoz
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F Pacini
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R Elisei
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seems to play a very central role in the pathogenesis of this tumor. B-RAF mutations have been described at high frequency in melanoma (70%) and, with a lower prevalence (10–20%), also in colon and ovarian cancer, in lung and stomach cancer and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01086
Volume/Issue:
Volume 13: Issue 2
Free access
Birke Bausch
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Ulrich Wellner 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Dirk Bausch 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Francesca Schiavi 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Marta Barontini 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Gabriela Sanso 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Martin K Walz 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Mariola Peczkowska 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Georges Weryha 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Patrizia Dall'Igna 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Giovanni Cecchetto 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Gianni Bisogno 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Lars C Moeller 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Detlef Bockenhauer 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Attila Patocs 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Karoly Rácz 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Dmitry Zabolotnyi 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Svetlana Yaremchuk 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Iveta Dzivite-Krisane 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Frederic Castinetti 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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David Taieb 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Angelica Malinoc 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Ernst von Dobschuetz 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Jochen Roessler 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Kurt W Schmid 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Giuseppe Opocher 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Charis Eng 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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Hartmut P H Neumann 2nd Department of Medicine, Department of Surgery, Department of Medicine, Center for Endocrinological Investigations (CEDIE), Department of Surgery, Department of Hypertension, Department of Endocrinology, Division of Pediatric Surgery, Pediatric Oncology, Department of Endocrinology, Department of Pediatrics, 2nd Department of Internal Medicine, Institute of Otorhinolaryngology, Department of Endocrinology, Department of Endocrinology, Department of Nuclear Medicine, Section for Preventive Medicine, Department of Visceral Surgery, Department of Pediatrics, Department of Pathology, Genomic Medicine Institute, University of Freiburg, Freiburg, Germany

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et al . 1990 , Ciftci et al . 2001 , Barontini et al . 2006 ). Prevalence of hereditary and malignant tumors is controversial, but of utmost importance for quality-of-life considerations and survivorship ( Ross 2000 , Barontini et al . 2006

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0415
Volume/Issue:
Volume 21: Issue 1
Free access
Achim Fleischmann Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, CH-3010 Bern, Switzerland

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, CH-3010 Bern, Switzerland

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Jean Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, CH-3010 Bern, Switzerland

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]-bombesin(6–14) as radioligands for GRP-receptors. Information about prevalence and quantity of GRP-receptor expressing tumor vessels and density of expressed GRP-receptors in these frequent cancers is particularly important to determine the potential value

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0316
Volume/Issue:
Volume 16: Issue 2
Free access
Francis Worden Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Martin Fassnacht Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA
Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Yuankai Shi Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA
Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Tatiana Hadjieva Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Françoise Bonichon Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Ming Gao Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Laura Fugazzola Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA
Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Yuichi Ando Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Yasuhisa Hasegawa Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Do Joon Park Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Young Kee Shong Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Johannes W A Smit Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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John Chung Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Christian Kappeler Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Gerold Meinhardt Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Martin Schlumberger Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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Marcia S Brose Division of Hematology/Oncology, Endocrine Unit, Comprehensive Cancer Center Mainfranken, Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Radiotherapy Department, Institut Bergonie, Tianjin Medical University Cancer Hospital, Fondazione IRCCS Ca' Granda, Department of Pathophysiology and Transplantation, Nagoya University Hospital, Aichi Cancer Center Hospital, Seoul National University College of Medicine, Asan Medicine Center, Department of Internal Medicine, Bayer HealthCare Pharmaceuticals, Bayer Pharma AG, Institut Gustave Roussy, Department of Otorhinolaryngology: Head and Neck Surgery, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA

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-scale trial in patients with RAI-refractory DTC, may provide insight into the management of patients receiving sorafenib in this setting. Here we report a detailed, by-cycle analysis of the incidence, prevalence, and severity of the most commonly reported and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0252
Volume/Issue:
Volume 22: Issue 6
Open access