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Takako Araki, Ning-Ai Liu, Yukiko Tone, Daniel Cuevas-Ramos, Roy Heltsley, Masahide Tone, and Shlomo Melmed

). Subcellular mechanisms for ectopic Cushing’s syndrome are poorly defined. ACTH produced by post-translational cleavage from the proopiomelanocortin (POMC) precursor is abundantly expressed in pituitary corticotroph cells and in the hypothalamus ( Stevens

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Luis G Perez-Rivas, Andrea Oßwald, Thomas Knösel, Kristin Lucia, Christian Schaaf, Michael Hristov, Julia Fazel, Thomas Kirchner, Felix Beuschlein, Martin Reincke, and Marily Theodoropoulou

precursor proopiomelanocortin (POMC, unprocessed or partially cleaved) or, less frequently, corticotropin-releasing hormone (CRH). Bronchial carcinoids and small cell carcinomas of the lung (SCLC) are the most frequent causes of EAS ( Alexandraki & Grossman

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Giampaolo Trivellin, Ricardo R Correa, Maria Batsis, Fabio R Faucz, Prashant Chittiboina, Ivana Bjelobaba, Darwin O Larco, Martha Quezado, Adrian F Daly, Stanko S Stojilkovic, T John Wu, Albert Beckers, Maya B Lodish, and Constantine A Stratakis

hypothalamic neurons expressing proopiomelanocortin ( POMC ), the precursor of ACTH ( Nilaweera et al . 2007 , Bagnol 2010 ). Moreover, GPR101 was shown to mediate the phosphorylation of epidermal growth factor receptor ( EGFR ), leading to enhanced cellular

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Anna Angelousi, Eva Kassi, Narjes Ansari-Nasiri, Harpal Randeva, Gregory Kaltsas, and George Chrousos

proopiomelanocortin (POMC) and PER2 ( Tsukamoto-Yamauchi et al. 2015 ). Knockdown of CLOCK gene significantly reduced prolactin mRNA levels in GH3 cell lines, whereas knockdown of BMAL1 did not induce any change ( Tsukamoto-Yamauchi et al. 2015 ). In vivo

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D E Schteingart, G M Doherty, P G Gauger, T J Giordano, G D Hammer, M Korobkin, and F P Worden

(metastasis, response to treatment) is not known but probable. The differential effects of ACTH vs additional proopiomelanocortin (POMC)-derived peptides (e.g. N-terminal fragment of POMC) on adrenocortical tissue is an area of active research

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Giampaolo Trivellin, Fabio R Faucz, Adrian F Daly, Albert Beckers, and Constantine A Stratakis

expression. Within the ARC, Gpr101 is expressed in about 50% of the neurons expressing the anorexigenic peptide proopiomelanocortin (POMC) ( Nilaweera et al. 2007 ) and in glutamatergic neurons ( Ieda et al. 2020 ), while thyrotropin-releasing hormone

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Tomoko Sekiya, Marcello D Bronstein, Katiuscia Benfini, Viviane C Longuini, Raquel S Jallad, Marcio C Machado, Tatiana D Goncalves, Luciana H Osaki, Leonardo Higashi, Jose Viana-Jr, Claudio Kater, Misu Lee, Sara Molatore, Guilherme Francisco, Roger Chammas, Michel S Naslavsky, David Schlesinger, Patricia Gama, Yeda A O Duarte, Maria Lucia Lebrão, Mayana Zatz, Osorio Meirelles, Bernardo Liberman, Maria Candida B V Fragoso, Sergio P A Toledo, Natalia S Pellegata, and Rodrigo A Toledo

downregulated in corticotropinomas, but not in other types of pituitary adenomas ( Dahia et al . 1998 ). Moreover, a crucial role for p27 in the regulation of the proliferation of pituitary proopiomelanocortin (POMC) cells producing ACTH has also been

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K E Lines, P Filippakopoulos, M Stevenson, S Müller, H E Lockstone, B Wright, S Knapp, D Buck, C Bountra, and R V Thakker

Tobin DJ White A 2007 Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis . FASEB Journal 1844 – 1856 . (

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Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Franco Cotelli, Diego Ferone, and Luca Persani

transforming gene ( pttg ) targeted to the adenohypophyseal proopiomelanocortin (Pomc) cells. PTTG is overexpressed in more than 90% of pituitary tumors, including ACTH-secreting pituitary adenomas ( Vlotides et al . 2007 ). Adult Tg:Pomc-Pttg fish developed

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Lisa D Berman-Booty and Karen E Knudsen

( van Haaften-Day et al . 1987 , Jelbart et al . 1989 ). These tumors also secrete a number of proopiomelanocortin (POMC)-derived hormones in vivo , including adrenocorticotrophic hormone (ACTH), somatostatin, and β-endorphin ( Jelbart et al . 1988