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Helena Schock Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Heljä-Marja Surcel Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Anne Zeleniuch-Jacquotte Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Kjell Grankvist Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Hans-Åke Lakso Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Renée Turzanski Fortner Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Rudolf Kaaks Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Eero Pukkala Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Matti Lehtinen Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Paolo Toniolo Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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Eva Lundin Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Division of Cancer Epidemiology, Department of Medical Biosciences, Unit of Sexual and Reproductive Health, Departments of Population Health and Environmental Medicine, New York University Cancer Institute, Finnish Cancer Registry, School of Health Sciences, Department of Obstetrics and Gynecology, Institute of Social and Preventive Medicine, Public Health and Clinical Medicine: Nutritional Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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, results from the three largest prospective studies on androgens reported thus far ( Rinaldi et al . 2007 , Tworoger et al . 2008 ) did not show any association with the risk or report any inverse association of androstenedione for invasive serous tumors

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0282
Volume/Issue:
Volume 21: Issue 6
Free access
S E Bojesen
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S K Kjær
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E V S Høgdall
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B L Thomsen
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C K Høgdall
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J Blaakær
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A Tybjærg-Hansen
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B G Nordestgaard
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). Therefore, other, presumably low-penetrant ovarian cancer susceptibility loci probably constitute the main bulk of the genetic contribution to ovarian cancer. In a recent large prospective study of the general population, we demonstrated that

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01083
Volume/Issue:
Volume 12: Issue 4
Free access
Tugba Barlas Department of Endocrinology and Metabolism, Gazi University, Faculty of Medicine, Ankara, Turkey

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Osman Sutcuoglu Department of Medical Oncology, Gazi University, Faculty of Medicine, Ankara, Turkey

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Orhun Akdogan Department of Medical Oncology, Gazi University, Faculty of Medicine, Ankara, Turkey

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Fusun Balos Toruner Department of Endocrinology and Metabolism, Gazi University, Faculty of Medicine, Ankara, Turkey

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Mujde Akturk Department of Endocrinology and Metabolism, Gazi University, Faculty of Medicine, Ankara, Turkey

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Nuriye Ozdemir Department of Medical Oncology, Gazi University, Faculty of Medicine, Ankara, Turkey

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Ozan Yazici Department of Medical Oncology, Gazi University, Faculty of Medicine, Ankara, Turkey

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Alev Eroglu Altinova Department of Endocrinology and Metabolism, Gazi University, Faculty of Medicine, Ankara, Turkey

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Immune checkpoint inhibitors (ICIs) can trigger immune-related adverse events (irAEs). The appearance pattern of irAEs, who is prone to them, and their mechanisms are still uncertain. In this study, we aimed to monitor patients initiated on ICIs for endocrinological aspects and to investigate the potential predictive markers in the development of endocrine-irAEs. The study prospectively included 43 patients with metastatic disease scheduled for anti-PD-1/L1 therapy. Endocrinological follow-up was conducted at specified intervals as well as in response to any additional reported complaints. Serum concentrations of CXCL10, IL-1beta, and IL-17A were measured prior to ICI and during the endocrine-irAEs. A total of 39.5% of the patients experienced endocrine-irAEs, with a median onset time of 3 months. Among patients, 34.9% developed thyroid-related adverse events, and 4.6% experienced hypophysitis. Thyroid autoantibodies were associated with a higher incidence of thyroid-related irAEs (P = 0.004). In the irAE group, median pre-ICI CXCL10 and baseline thyroid stimulating hormone (TSH) levels were significantly higher, baseline total testosterone level in men was lower than in the non-irAE group (P < 0.05), whereas IL-1beta and IL-17A levels did not differ (P > 0.05). Serum CXCL10, IL-1beta, and IL-17A concentrations did not differ significantly pre-ICI and during adverse events (P > 0.05). Pre-ICI CXCL10 concentration was correlated positively with anti-TPO levels in patients with at least one thyroid autoantibody positivity (r = 0.706, P = 0.01) and negatively with baseline total testosterone level of men (r = 0.509, P = 0.002). Our results suggest that higher pre-ICI serum CXCL10 and TSH levels might have a predictive role in the development of endocrinopathies. Besides, baseline thyroid antibody measurements could be beneficial in predicting thyroid dysfunction.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0101
Volume/Issue:
Volume 31: Issue 11
Restricted access
Jolanta Krajewska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Memorial Institute – Cancer Center, Gliwice, Poland

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Ewa Chmielik Tumor Pathology Department, M. Sklodowska-Curie Memorial Institute – Cancer Center, Gliwice, Poland

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Barbara Jarząb Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Memorial Institute – Cancer Center, Gliwice, Poland

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risk stratification are encouraging; however, the data require a validation in prospective studies ( Lindsey et al . 2015 , Kwon et al . 2016 ). Both studies based the evaluation of treatment response on the following criteria: serum calcitonin and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0270
Volume/Issue:
Volume 24: Issue 11
Free access
Leigh C Murphy
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Peter H Watson
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, the retrospectively collected data summarised above investigating the relationship between ER β when coexpressed with ER α and clinical outcome, strongly support the undertaking of definitive prospective studies to determine if the addition of ER β to

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01141
Volume/Issue:
Volume 13: Issue 2
Free access
Gabriela Franco Mourão Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil
Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

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Pedro Weslley Rosario Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil
Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

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Maria Regina Calsolari Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

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, Angell et al . 2014 ). This prospective study evaluated the recurrence rate in patients with PTC who had low nonstimulated Tg, measured with a second-generation assay, and negative neck US after total thyroidectomy and who were not submitted to ablation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0458
Volume/Issue:
Volume 23: Issue 1
Free access
Giorgio Secreto Epidemiology and Prevention Unit, Fondazione IRCCS – Istituto Nazionale dei Tumori, Milano, Italy

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Paola Muti Department of Oncology, McMaster University, Hamilton, Ontario, Canada

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Milena Sant Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milano, Italy

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Elisabetta Meneghini Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milano, Italy

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Vittorio Krogh Epidemiology and Prevention Unit, Fondazione IRCCS – Istituto Nazionale dei Tumori, Milano, Italy

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factor † * DHT, dihydrotestosterone; † this mechanism is active in several tumors type. High testosterone levels and risk of disease progression: epidemiological evidence A number of epidemiological prospective studies

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-17-0251
Volume/Issue:
Volume 24: Issue 11
Free access
G Azizi Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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J M Keller Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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M Lewis Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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K Piper Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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D Puett Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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K M Rivenbark Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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C D Malchoff Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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study. All patients were divided based on TSH level. Discussion Our prospective study of patients with TN demonstrates that an elevated serum TgAb concentration is an independent predictor for TC. Serum TPOAb concentration was not a predictor of TC in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0258
Volume/Issue:
Volume 21: Issue 6
Open access
Cher M Dallal Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA
Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Louise A Brinton Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Douglas C Bauer Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Diana S M Buist Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Jane A Cauley Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Trisha F Hue Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Andrea LaCroix Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Jeffrey A Tice Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Victoria M Chia Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Roni Falk Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Ruth Pfeiffer Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Michael Pollak Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Timothy D Veenstra Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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Xia Xu Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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James V Lacey Jr Hormonal and Reproductive Epidemiology Branch, Cancer Prevention Fellowship Program, Department of Medicine, Group Health Research Institute, Department of Epidemiology, Department of Epidemiology and Biostatistics, Department of Epidemiology, Biostatistics Branch, Jewish General Hospital, Advanced Technology Program, Division of Cancer Etiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 550, Bethesda, Maryland 20852, USA

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for the B∼FIT Research Group
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positively associated with endometrial cancer based on findings from case–control studies ( Petridou et al . 2002 , Cymbaluk et al . 2008 , Ashizawa et al . 2010 ). To date, no prospective studies have evaluated leptin in relation to endometrial cancer

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0229
Volume/Issue:
Volume 20: Issue 1
Free access
Wafa Bouleftour Department of Medical Oncology, Lucien Neuwirth cancer institute, Saint Priest en Jarez, Rhône-Alpes, France

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Karima Boussoualim Department of rheumatology, North Hospital, university Hospital of Saint-Étienne, Saint-Priest-en-Jarez, Rhône-Alpes, France

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Sandrine Sotton Department of Radiotherapy, Lucien Neuwirth Cancerology Institute, Saint Priest en Jarez, Rhône-Alpes, France

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Cecile Vassal Department of Medical Oncology, Lucien Neuwirth cancer institute, Saint Priest en Jarez, Rhône-Alpes, France

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Thierry Thomas Department of rheumatology, North Hospital, university Hospital of Saint-Étienne, Saint-Priest-en-Jarez, Rhône-Alpes, France

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Nicolas Magne Department of Radiotherapy, Lucien Neuwirth Cancerology Institute, Saint Priest en Jarez, Rhône-Alpes, France

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Aline Guillot Department of Medical Oncology, Lucien Neuwirth cancer institute, Saint Priest en Jarez, Rhône-Alpes, France

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prospective study. This article aims at reviewing what is known about the impact of second-generation hormonotherapy on the bone microenvironment. Androgen actions on bone All life long, normal bone undergo remodelling for the skeletal integrity to be

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-21-0118
Volume/Issue:
Volume 28: Issue 8
Free access