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Jennifer L Bishop The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Alastair Davies The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Kirsi Ketola The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Amina Zoubeidi The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Introduction Prostate cancer (PCa) has become the most common form of cancer in men in the developed world, and it ranks second in cancer-related deaths, with the vast majority of these fatalities resulting from metastatic disease ( Siegel et al

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Stefano Mangiola Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Division of Bioinformatics, Walter and Eliza Hall Institute, Parkville, Victoria, Australia

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Ryan Stuchbery Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Geoff Macintyre Centre for Neural Engineering, Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
Diagnostic Genomics, NICTA, Victoria Research Laboratory, The University of Melbourne, Parkville, Victoria, Australia

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Michael J Clarkson Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Justin S Peters Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Anthony J Costello Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Christopher M Hovens Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Niall M Corcoran Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia

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Introduction Prostate cancer is the most widely diagnosed cancer among men in developed countries and the second most diagnosed cancer in men worldwide ( Torre et al . 2015 ). The widespread use of serum PSA measurement as an ad hoc community

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Tanya K Day
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Tina Bianco-Miotto Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia
Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia

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Introduction Numerous diseases are associated with abnormal hormonal regulation including breast and prostate cancers. Breast cancer is a heterogeneous disease that can be classified in many ways. The most primary classification is by hormone

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Stefan J Barfeld Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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Harri M Itkonen Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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Alfonso Urbanucci Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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Ian G Mills Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway
Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway
Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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) ( DeBerardinis et al . 2008 ). It is therefore not surprising that metabolic adaptations have been reported in various human cancers ( Hsu & Sabatini 2008 ). Metabolic status of the prostate gland and cancer predisposition The prostate gland is principally

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Douglas W Strand Department of Urology, Department of Molecular and Medical Pharmacology, University of Texas Southwestern, Dallas, Texas, USA

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Andrew S Goldstein Department of Urology, Department of Molecular and Medical Pharmacology, University of Texas Southwestern, Dallas, Texas, USA

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. The regulation of these progenitors has been the subject of intense research and debate with implications for a wide range of diseases, including those of the prostate. Because of the resistance of prostate progenitor cells to current anti

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Hidewaki Nakagawa Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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Introduction Prostate cancer (PC) is the most common malignancy in men and the second leading cause of cancer-related deaths in Western countries. Incidence and mortality rates vary widely across geographic regions and ethnic groups ( Gronberg 2003

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Su Liu George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Shin-Jen Lin George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Gonghui Li George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Eungseok Kim George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Yei-Tsung Chen George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Dong-Rong Yang George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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M H Eileen Tan George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Eu Leong Yong George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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Chawnshang Chang George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
George Whipple Laboratory for Cancer Research, Department of Obstetrics and Gynecology, Chawnshang Chang Liver Cancer Center and Department of Urology, Department of Biological Sciences, Cardiovascular Research Institute, Sex Hormone Research Center, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA

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that inactivation of ARA55 inhibits the agonist effect of antiandrogens in prostate cancer (PCa) cells ( Rahman et al . 2003 ). Does increased TR4 activity induced by ARA55 inactivation play a role here? Further experiments are needed to answer this

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Alastair H Davies Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Amina Zoubeidi Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Vancouver Prostate Centre, Vancouver, British Columbia, Canada

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Introduction Prostate cancer was first identified by Adams in 1853. Adams noted that the condition was 'a very rare disease' ( Adams 1853 ). Prostate cancer has become one of the most common cancers in men: nearly 200,000 men are diagnosed

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Maho Shibata Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA

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Michael M Shen Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA

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Introduction For the past 70 years, androgen-deprivation therapy has remained the mainstay of treatment for prostate cancer. Although most prostate cancers initially respond to androgen deprivation, many will ultimately progress to lethal castration

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Amina Zoubeidi Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Paramita M Ghosh Department of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, California, USA
Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, California, USA
Department of Veterans Affairs, Northern California Health Care System, Mather, California, USA

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Introduction Localized prostate cancer can be treated with surgery; however, metastasized prostate cancer is usually treated with hormonal ablation. Improved diagnostic tools and earlier diagnosis has helped increase the 10-year survival of

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