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Verónica A Bahamondes Lorca Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile

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Shiyong Wu Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA

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hormone, and how this hormone induces radioresistance due to an increase in the capacity of cellular DNA repair. Radiation therapy of the hypothalamic–pituitary area and growth hormone deficiency Radiotherapy and growth hormone deficiency The

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-22-0371
Volume/Issue:
Volume 31: Issue 3
Restricted access
Reetobrata Basu Edison Biotechnology Institute, Athens, Ohio, USA

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John J Kopchick Edison Biotechnology Institute, Athens, Ohio, USA
Molecular and Cellular Biology Program, Ohio University, Athens, Ohio, USA
Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA

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poorer response to therapy associated with higher GHR expression ( Wu et al. 2006 ). The major underlying mechanisms of GH-induced radio-resistance, as recently described by Melmed and colleagues, largely lie in radiation-induced DNA damage, leading to

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0414
Volume/Issue:
Volume 30: Issue 9
Free access
Nicola M Bougen The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand
The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Michael Steiner The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Mikhail Pertziger The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Arindam Banerjee The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Severine E Brunet-Dunand The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Tao Zhu The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Peter E Lobie The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand
The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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Jo K Perry The Liggins Institute, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, Cancer Science Institute of Singapore and Department of Pharmacology, University of Auckland, 2-6 Park Avenue, Private Bag 92019, Auckland 1023, New Zealand

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growth factor receptor (HER) family have been demonstrated to promote radioresistance through multiple mechanisms ( Jameel et al . 2004 , Dumont et al . 2009 , Zaidi et al . 2009 ). Accumulating evidence indicates a role for human GH (hGH) in human

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0042
Volume/Issue:
Volume 19: Issue 5
Free access
Chun-Te Wu
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Wen-Cheng Chen
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Shuen-Kuei Liao
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Cheng-Lung Hsu
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Kuan-Der Lee
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Miao-Fen Chen
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that concurrent androgen deprivation failed to radiosensitize 22RV1 cells. In contrast, HR cells induced by long-term androgen deprivation had significantly greater radioresistance when compared with control cells, which was noted in both 22RV1 and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0073
Volume/Issue:
Volume 14: Issue 3
Free access
Olga Lakiza Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

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Julian Lutze Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA

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Alyx Vogle Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

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Jelani Williams Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

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Abde Abukdheir Division of Hematology, Oncology, and Cell Therapy, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA

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Paul Miller Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

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Chih-Yi ‘Andy’ Liao Division of Hematology and Oncology, Department of Internal Medicine, University of Chicago, Chicago, Illinois, USA

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Sean P Pitroda Department of Radiation Oncology and Cellular Biology, University of Chicago, Chicago, Illinois, USA

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Carlos Martinez Department of Radiation Oncology and Cellular Biology, University of Chicago, Chicago, Illinois, USA

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Andrea Olivas Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Namrata Setia Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Stephen J Kron Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, USA

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Ralph R Weichselbaum Department of Radiation Oncology and Cellular Biology, University of Chicago, Chicago, Illinois, USA
Ludwig Center for Metastasis Research, University of Chicago, Chicago, Illinois, USA

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Xavier M Keutgen Endocrine and Neuroendocrine Surgery Research Program, Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA

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specific mechanisms remain to be determined. Treating tumors with ionizing radiation (IR) using external beam radiation (EBRT) can control the local progression of many cancers. While anecdotal observations of radioresistance in neuroendocrine tumors

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0247
Volume/Issue:
Volume 29: Issue 4
Restricted access
J M Gee
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J F Robertson
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E Gutteridge
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I O Ellis
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S E Pinder
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M Rubini
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R I Nicholson
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, it has been reported that increased IGF-1R signalling occurs in acquired radioresistance ( Turner et al. 1997 ). If our clinical results are considered alongside the limited model system data, the importance of IGF-1R signalling to ER + or ER

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01005
Volume/Issue:
Volume 12: Issue Supplement_1
Free access
Adly Yacoub
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Anna Miller
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Ruben W Caron
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Liang Qiao
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David A Curiel
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Paul B Fisher
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Michael P Hagan
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Steven Grant
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Paul Dent
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also promote radioresistance by loss of p53-induced apoptosis after DNA damage. To further investigate the relative roles of ERBB1 and ERBB2 in HCT116 cell signaling after radiation exposure, cells were incubated with the ERBB1 inhibitor AG1478

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01271
Volume/Issue:
Volume 13: Issue Supplement_1
Free access
Xi Zhang Shenzhen Bay Laboratory, Shenzhen, P R China

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Vijay Pandey Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Vipul Bhardwaj Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Tao Zhu Shenzhen Bay Laboratory, Shenzhen, P R China
Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P R China
The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P R China

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Peter E Lobie Shenzhen Bay Laboratory, Shenzhen, P R China
Tsinghua Berkeley Shenzhen Institute and Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P R China

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Growth in 3D Matrigel ( Bougen et al. 2011 ) Primary mammary carcinoma cells JAK2 – Cell viability ( Chiesa et al. 2011 ) MDA-MB-435S T47D JAK2/c-SRC BRCA2 XRCC2 hTERT Radioresistance Total cell number Cell survival

Article Type:
Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-23-0120
Volume/Issue:
Volume 31: Issue 1
Restricted access
Andrea Weckman Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Fabio Rotondo Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Antonio Di Ieva Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Luis V Syro Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Henriett Butz Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Michael D Cusimano Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Kalman Kovacs Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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- and radioresistance respectively ( Lin et al . 2009 ). Moreover, the use of RAD001, an mTOR inhibitor that induces autophagy in PTC cells, in conjunction with doxorubicin or external beam radiation, increased their anticancer effects ( Lin et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0042
Volume/Issue:
Volume 22: Issue 4
Free access
Eric Monsalves Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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Kyle Juraschka Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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Toru Tateno Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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Sameer Agnihotri Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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Sylvia L Asa Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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Shereen Ezzat Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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Gelareh Zadeh Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science

Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada

Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8

Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada

Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada

Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada

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inhibition may also lead to decreased radioresistance of PA cells in vitro . Sukumari-Ramesh et al . (2011) report that inhibition of mTOR radiosensitizes GH3 cells such that 2.5 Gy in combination with 0.5 nM rapamycin or RAD001 reduced cellular viability

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0188
Volume/Issue:
Volume 21: Issue 4
Free access