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Takuya Mikoshiba
Takuya Mikoshiba
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Mariko Sekimizu
Mariko Sekimizu
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Shin Saito
Shin Saito
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Shintaro Nakamura
Shintaro Nakamura
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Ryoto Nagai
Ryoto Nagai
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Miho Kawaida
Miho Kawaida
Division of Diagnostic Pathology, Keio University Hospital, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Isao Kurihara
Isao Kurihara
Division of Medical Education Improvement and Planning, Medical Education and Clinical Training Center, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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Sakiko Kobayashi
Sakiko Kobayashi
Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
Department of Endocrinology, Metabolism and Nephrology, NHO Tokyo Medical Center, Higashigaoka, Meguro-ku, Tokyo, Japan
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Department of Endocrinology, Metabolism and Nephrology, NHO Tokyo Medical Center, Higashigaoka, Meguro-ku, Tokyo, Japan
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Hiroyuki Ozawa
Hiroyuki Ozawa
Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan
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. Moreover, the timing and triggers of the development of EAS in ONB remain unclear. Elucidating these factors is crucial because ONB is a slow-growing neoplasm with the potential for recurrence and metastasis over an extended period. This study aims to
Qiao Zheng
Qiao Zheng
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Lauren Banaszak
Lauren Banaszak
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Sarah Fracci
Sarah Fracci
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Diana Basali
Diana Basali
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Sarah M Dunlap
Sarah M Dunlap
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Stephen D Hursting
Stephen D Hursting
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Jeremy N Rich
Jeremy N Rich
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Anita B Hjlemeland
Anita B Hjlemeland
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Amit Vasanji
Amit Vasanji
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Nathan A Berger
Nathan A Berger
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Justin D Lathia
Justin D Lathia
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Ofer Reizes
Ofer Reizes
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cellular and Molecular Medicine, Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Department of Stem Cell Biology and Regenerative Medicine, ImageIQ, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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are recently discovered cancer cells that reside in the subsets of breast tumors including TNBCs. CSCs have the ability to self-renew and may be associated with recurrence and metastasis in breast cancer ( Al-Hajj et al . 2003 , Liu & Wicha 2010
Wei Wei
Wei Wei
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
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Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
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Michael T Lewis
Michael T Lewis
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
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Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
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these are the issues of treatment resistance, disease recurrence, and metastasis. For example, whereas many ER + tumors respond to ER-targeted therapies (antiestrogens such as tamoxifen and aromatase inhibitors such as anastrozole, letrozole, and
Adam I Kaplan
Adam I Kaplan
A Kaplan, Cancer Genetics Laboratory, Kolling Institute of Medical Research, St Leonards, Australia
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Trisha Dwight
Trisha Dwight
T Dwight, Cancer Genetics Laboratory, Kolling Institute of Medical Research, St Leonards, Australia
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Catherine Luxford
Catherine Luxford
C Luxford, Cancer Genetics Laboratory, Kolling Institute of Medical Research, St Leonards, Australia
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Diana E Benn
Diana E Benn
D Benn, Cancer Genetics Laboratory, Kolling Institute of Medical Research, St Leonards, Australia
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Roderick J. Clifton-Bligh
Roderick J. Clifton-Bligh
R Clifton-Bligh, Cancer Genetics Laboratory, Kolling Institute of Medical Research, St Leonards, Australia
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Phaeochromocytomas and paragangliomas (collectively termed PPGLs) are rare yet highly heritable neuroendocrine tumours, with over one third of cases associated with germline pathogenic variants (PVs) in numerous genes. PVs in succinate dehydrogenase subunit-A gene (SDHA) were initially implicated in hereditary PPGL in 2010 and SDHA has since become an important susceptibility gene accounting for up to 2.8 % of cases. However, it remains poorly understood, particularly regarding the clinical nature of SDHA PPGL, rates of recurrence and metastasis, and nature of metastatic disease. We present a narrative review of SDHA-related PPGL, covering pathophysiology, relevance to current clinical practice, and considerations for clinical genetics. We analyse a pool of 107 previously reported cases of SDHA-associated PPGL to highlight the spectrum of SDHA-related PPGL. Our analysis demonstrates SDHA PPGL occurs across a wide age-range (11-81 y) and affects men and women equally. SDHA PPGL typically present as single tumours (91%), usually occurring in the head and neck (46%) or abdomen (43%, including 15% with phaeochromocytomas). Metastatic disease was reported in 25.5% cases with bone (82%) and lymph nodes (71%) being the most common sites of metastasis, often identified many years after initial diagnosis. Family history of SDHA-related neoplasia was rare, reported in only 4% of cases. Understanding the clinical nature and risks associated with SDHA PVs is essential for facilitating optimal management of patients and their families.
Qiao Zheng
Qiao Zheng
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Sarah M Dunlap
Sarah M Dunlap
Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Jinling Zhu
Jinling Zhu
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Erinn Downs-Kelly
Erinn Downs-Kelly
Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Jeremy Rich
Jeremy Rich
Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Stephen D Hursting
Stephen D Hursting
Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Nathan A Berger
Nathan A Berger
Department of Cell Biology, Department of Nutritional Sciences, Department of Carcinogenesis, Department of Anatomic Pathology, Department of Stem Cell Biology and Regenerative Medicine, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA
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Ofer Reizes
Ofer Reizes
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cancer ( Calle et al . 2003 ). Furthermore, obese patients are at greater risk of tumor recurrence and metastasis resulting in poor overall survival ( Loi et al . 2005 , Huber et al . 2009 ). Breast cancer is the second leading cause of cancer death
David Fu
David Fu
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Xiangmin Lv
Xiangmin Lv
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Guohua Hua
Guohua Hua
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Chunbo He
Chunbo He
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Jixin Dong
Jixin Dong
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Subodh M Lele
Subodh M Lele
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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David Wan-Cheng Li
David Wan-Cheng Li
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Qiongli Zhai
Qiongli Zhai
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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John S Davis
John S Davis
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Cheng Wang
Cheng Wang
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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progression, recurrence, and metastasis are largely unknown. Oftentimes, GCTs are hemorrhagic and manifest as painful abdominal masses, with an average diameter more than 10 cm ( Young et al . 1984 , Aboud 1997 , Ko et al . 1999 , Sehouli et al . 2004
Nancy D Perrier
Nancy D Perrier
Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Andrew Arnold
Andrew Arnold
Center for Molecular Oncology and Division of Endocrinology & Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut, USA
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Jessica Costa-Guda
Jessica Costa-Guda
Center for Regenerative Medicine & Skeletal Development, Center for Molecular Oncology, University of Connecticut School of Medicine/Dental Medicine, Farmington, Connecticut, USA
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Naifa L Busaidy
Naifa L Busaidy
Department of Endocrine Neoplasia & Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Ha Nguyen
Ha Nguyen
Department of Medicine-Endocrinology, Baylor College of Medicine, Houston, Texas, USA
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Hubert H Chuang
Hubert H Chuang
Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
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Maria Luisa Brandi
Maria Luisa Brandi
Department of Endocrinology, University of Florence, Medical School, Florence, Italy
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metastatic parathyroid carcinoma, allowing for (a) careful study of the biologic contributors of recurrence and metastasis and (b) testing of therapeutic interventions. The currently available model systems fall short of these goals. Several are discussed
Liyan Zhou
Liyan Zhou
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Guiying Bai
Guiying Bai
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yue Song
Yue Song
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xiaohui Liu
Xiaohui Liu
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xiaoqing Li
Xiaoqing Li
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yilin Deng
Yilin Deng
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yiran Si
Yiran Si
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yehui Shi
Yehui Shi
Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Hongli Li
Hongli Li
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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of AGEs in breast cancer were systematically investigated, and the molecular mechanism of recurrence and metastasis in breast cancer patients with diabetes was explored. We demonstrated that AGEs function as tumor promoters in breast cancer patients
Lauren N Pontius
Lauren N Pontius
Duke University Medical Center, Durham, North Carolina, USA
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Linda M Youngwirth
Linda M Youngwirth
Duke University Medical Center, Durham, North Carolina, USA
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Samantha M Thomas
Samantha M Thomas
Duke University Medical Center, Durham, North Carolina, USA
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Randall P Scheri
Randall P Scheri
Duke University Medical Center, Durham, North Carolina, USA
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Sanziana A Roman
Sanziana A Roman
Duke University Medical Center, Durham, North Carolina, USA
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Julie A Sosa
Julie A Sosa
Duke University Medical Center, Durham, North Carolina, USA
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recurrence and metastasis (2.2% rate without LVI/capsular invasion, 9.2% rate with LVI/capsular invasion, P <0.01). Although this study demonstrated an association between LVI and disease recurrence, it was limited to PTC <1cm in diameter, and did not
Florian Bösch
Florian Bösch
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Katharina Brüwer
Katharina Brüwer
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Annelore Altendorf-Hofmann
Annelore Altendorf-Hofmann
Department of General, Visceral und Vascular Surgery, Friedrich-Schiller University, Jena, Germany
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Christoph J Auernhammer
Christoph J Auernhammer
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, Ludwig-Maximilians-University Munich, Munich, Germany
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Department of Internal Medicine 4, Ludwig-Maximilians-University Munich, Munich, Germany
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Christine Spitzweg
Christine Spitzweg
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, Ludwig-Maximilians-University Munich, Munich, Germany
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Department of Internal Medicine 4, Ludwig-Maximilians-University Munich, Munich, Germany
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C Benedikt Westphalen
C Benedikt Westphalen
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany
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Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany
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Stefan Boeck
Stefan Boeck
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany
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Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany
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Gabriele Schubert-Fritschle
Gabriele Schubert-Fritschle
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Munich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-University Munich, Munich, Germany
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Munich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-University Munich, Munich, Germany
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Jens Werner
Jens Werner
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Volker Heinemann
Volker Heinemann
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany
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Department of Medicine 3 and Comprehensive Cancer Center, Ludwig-Maximilians-University Munich, Munich, Germany
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Thomas Kirchner
Thomas Kirchner
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
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Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
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Martin Angele
Martin Angele
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
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Thomas Knösel
Thomas Knösel
Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, Ludwig-Maximilians-University of Munich, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
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Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
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Zhang GQ Guan Y Wang JL 2017 Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer . Cancer Gene Therapy 24 57 – 63 . ( https://doi.org/10.1038/cgt.2016.40 ) 10.1038/cgt.2016.40 28084319
