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Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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Nassim Saremi Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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thyroid cancer ( Hizawa et al . 1996 ). No detail of the cytological feature was given in the report. In 2010, Koo and coworkers from South Korea described the cytological features of five CMV-PTCs as well as reviewing 10 cases from the previous studies

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Alfred King-yin Lam School of Medicine, Griffith University, Gold Coast, Australia

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squamous cell carcinoma of thyroid. This review aims to address this gap of knowledge by analysing the features of squamous cell carcinoma of thyroid and their relationships with other tumours of the thyroid gland. Method Primary squamous cell

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Tiago Bordeira Gaspar i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
ICBAS – Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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José Manuel Lopes i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar e Universitário de São João, Porto, Portugal

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Paula Soares i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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João Vinagre i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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animal models, and this review will only focus on them. In PanNENs, the most validated mouse models have been genetically programmed: (1) to conditionally activate oncogenes under relevant promoters (e.g. insulin and preproglucagon) or (2) to mimic PanNET

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Frederic Castinetti Department of Endocrinology, Aix Marseille University, CNRS UM 7286, Assistance Publique Hopitaux de Marseille, Marseille, France

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Jeffrey Moley Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA

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Lois Mulligan Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada

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Steven G Waguespack Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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review is to give detailed insights on the genetics, natural history and management of MEN2B, in addition to specific points that should be detailed in future large-scale studies. Genetics of MEN2B MEN2B, similar to MEN2A, is due to autosomal

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Pierpaolo Trimboli Department of Nuclear Medicine and Thyroid Centre, Section of Endocrinology and Diabetology, Nuclear Medicine, Endocrine Unit, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland
Department of Nuclear Medicine and Thyroid Centre, Section of Endocrinology and Diabetology, Nuclear Medicine, Endocrine Unit, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland

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Ettore Seregni Department of Nuclear Medicine and Thyroid Centre, Section of Endocrinology and Diabetology, Nuclear Medicine, Endocrine Unit, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland

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Giorgio Treglia Department of Nuclear Medicine and Thyroid Centre, Section of Endocrinology and Diabetology, Nuclear Medicine, Endocrine Unit, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland

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Maria Alevizaki Department of Nuclear Medicine and Thyroid Centre, Section of Endocrinology and Diabetology, Nuclear Medicine, Endocrine Unit, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland

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Luca Giovanella Department of Nuclear Medicine and Thyroid Centre, Section of Endocrinology and Diabetology, Nuclear Medicine, Endocrine Unit, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland

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entire process chain and are easier to manage in clinical practice. These characteristics give ProCT great potential to replace CT as a marker for detecting and managing MTC patients. To date, no review on this topic has, to our knowledge, been published

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Mirela Diana Ilie Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Endocrinology Department, ‘C.I. Parhon’ National Institute of Endocrinology, Bucharest, Romania

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Alexandre Vasiljevic Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Pathology Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France

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Emmanuel Jouanneau Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Neurosurgery Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France

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Gérald Raverot Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, ‘Groupement Hospitalier Est’ Hospices Civils de Lyon, Bron, France

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tumors, followed by a systematic review of all published cases, analyzing both treatment response and potential predictors of response and finishing with research and clinical perspectives. The aim is to highlight key clinical aspects that can already be

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Hong-Jun Song Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Yan-Li Xue Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Yan-Hong Xu Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Zhong-Ling Qiu Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Quan-Yong Luo Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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131 I-SPECT/CT imaging fusion techniques, rare metastasis in DTC is increasingly becoming an incidental finding ( Chen et al . 2008 , Qiu et al . 2011 ). This pictorial review highlights the diagnostic aspects of 131 I-SPECT/CT for the localization

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Sergio Vargas-Salas Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile

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José R Martínez Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile

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Soledad Urra Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile

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José Miguel Domínguez Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

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Natalia Mena GeneproDX, Santiago, Chile

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Thomas Uslar Department of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

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Marcela Lagos Department of Clinical Laboratories, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

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Marcela Henríquez Department of Clinical Laboratories, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

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Hernán E González Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile , Santiago, Chile

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interpretation, while helping to appropriately select patients that will benefit from molecular testing. This review is aimed to contribute to a better knowledge of the available molecular tests, their technical characteristics and clinical performance, through a

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Emanuel Christ Division of Endocrinology, Diabetology and Metabolism, University Hospital of Basel, University of Basel, Basel, Switzerland
Center for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel Switzerland

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Kwadwo Antwi Clinic of Radiology and Nuclear Medicine, University Hospital, Basel, Switzerland

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Melpomeni Fani Clinic of Radiology and Nuclear Medicine, University Hospital, Basel, Switzerland

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Damian Wild Center for Neuroendocrine and Endocrine Tumors, University Hospital Basel, Basel Switzerland
Clinic of Radiology and Nuclear Medicine, University Hospital, Basel, Switzerland

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is not a suitable diagnostic tool. Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding The study was supported by the Swiss

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Kellie L Jones
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Aman U Buzdar
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suppression with luteinizing hormone releasing factor (LHRH) agonists offer different mechanisms to suppress estrogen production and action and these agents have better safety profiles compared with tamoxifen. This article will review each of these hormonal

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