tissue sections ( Shi et al. 2014 , Haglund et al. 2016 ). Although great efforts have been dedicated towards heterogeneity, our present understanding is mainly limited to the tumour cells ( Verdelli et al. 2020 ). Single-cell RNA sequencing
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Xiang Zhang, Ya Hu, Ming Cui, Mengyi Wang, Xiaobin Li, Yalu Zhang, Sen Yang, Surong Hua, Meiping Shen, and Quan Liao
Neil A Bhowmick, Jillian Oft, Tanya Dorff, Sumanta Pal, Neeraj Agarwal, Robert A Figlin, Edwin M Posadas, Stephen J Freedland, and Jun Gong
susceptibility to SARS-CoV-2 infection compared to control ( Fan et al . 2020 ). Moreover, one group using adult human testis single-cell RNA sequencing demonstrated that TMPRSS2 expression was concentrated in spermatogonia and spermatids with relatively low
Thalles Fernando Rocha Ruiz, Simone J Colleta, Ellen C R Leonel, and Sebastião Roberto Taboga
H Tsiobikas C Selfors LM Chen H Rosenbluth J Moore K Gupta KP Gray GK Oren Y 2020 Aging-associated alterations in mammary epithelia and stroma revealed by single-cell RNA sequencing . Cell Reports 33 108566 . ( https://doi.org/10
J T W Kwon, R J Bryant, and E E Parkes
hormone-sensitive prostate cancer using single-cell RNA-sequencing . Journal of Clinical Oncology 38 (Supplement 15) e17548. ( https://doi.org/10.1200/JCO.2020.38.15_suppl.e17548 ) He MX Cuoco MS Crowdis J Bosma-Moody A Zhang Z Bi K
Charlotte Nys, Yu-Lun Lee, Heleen Roose, Freya Mertens, Ellen De Pauw, Hiroto Kobayashi, Raf Sciot, Marie Bex, Georges Versyck, Steven De Vleeschouwer, Johannes Van Loon, Emma Laporte, and Hugo Vankelecom
use WNT/RSPO activation signals, all hallmarks of current-concept organoid/tumoroid models ( Schutgens & Clevers 2020 ). Interestingly, the study performed single-cell RNA-sequencing (scRNA-seq) analysis and revealed the presence of pituitary stem
Robert Clarke, John J Tyson, Ming Tan, William T Baumann, Lu Jin, Jianhua Xuan, and Yue Wang
Teichmann SA Marioni JC Stegle O 2015 Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells . Nature Biotechnology 33 155 – 160 . ( https://doi.org/10.1038/nbt.3102 ) 10
