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D Campana Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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F Nori Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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R Pezzilli Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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L Piscitelli Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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D Santini Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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E Brocchi Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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R Corinaldesi Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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P Tomassetti Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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somatostatin analog treatment in type I gastric endocrine tumors. Patients and methods From January 2000 to December 2006, all patients admitted to our unit with gastric endocrine tumors underwent the following study protocol. A baseline visit was made in which

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0251
Volume/Issue:
Volume 15: Issue 1
Free access
Iulia Potorac CHU de Liège-University of Liège, Liège, Belgium

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Patrick Petrossians CHU de Liège-University of Liège, Liège, Belgium

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Adrian F Daly CHU de Liège-University of Liège, Liège, Belgium

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Orsalia Alexopoulou Université Catholique de Louvain, Brussels, Belgium

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Sophie Borot CHU Jean Minjoz, Besancon, France

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Mona Sahnoun-Fathallah CHU Marseille, Marseille, France

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Frederic Castinetti CHU Marseille, Marseille, France

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France Devuyst Université Libre de Bruxelles, Bruxelles, Belgium

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Marie-Lise Jaffrain-Rea Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila and Neuroendocrinology, Neuromed IRCCS, Pozzilli, Italy

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Claire Briet CHU Angers, Angers, France

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Florina Luca CHU Strasbourg, Strasbourg, France

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Marion Lapoirie CHU Lyon, Lyon, France

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Flavius Zoicas Universitätsklinikum Erlangen, Erlangen, Germany

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Isabelle Simoneau CHU Bocage, Dijon, France

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Alpha M Diallo CHU Reims, Reims, France

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Ammar Muhammad Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

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Fahrettin Kelestimur Faculty of Medicine, Erciyes University, Kayseri, Turkey

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Elena Nazzari University of Genova, Genova, Italy

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Rogelio Garcia Centeno Hospital Universitario Gregorio Marañon, Madrid, Spain

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Susan M Webb Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Marie-Laure Nunes CHU Bordeaux, Bordeaux, France

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Vaclav Hana Charles University, Prague, Czech Republic

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Véronique Pascal-Vigneron CHU Nancy, Nancy, France

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Irena Ilovayskaya Moscow Regional Research and Clinical Institute, Russia

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Farida Nasybullina Kazan State Medical Academy, Kazan, Russia

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Samia Achir Centre Pierre et Marie Curie, Algiers, Algeria

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Diego Ferone University of Genova, Genova, Italy

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Sebastian J C M M Neggers Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

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Brigitte Delemer CHU Reims, Reims, France

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Jean-Michel Petit CHU Bocage, Dijon, France

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Christof Schöfl Center of Endocrinology & Metabolism, Bamberg, Germany

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Gerald Raverot CHU Lyon, Lyon, France

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Bernard Goichot CHU Strasbourg, Strasbourg, France

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Patrice Rodien CHU Angers, Angers, France

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Bernard Corvilain Université Libre de Bruxelles, Bruxelles, Belgium

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Thierry Brue CHU Marseille, Marseille, France

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Franck Schillo CHU Jean Minjoz, Besancon, France

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Luaba Tshibanda CHU de Liège-University of Liège, Liège, Belgium

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Dominique Maiter Université Catholique de Louvain, Brussels, Belgium

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Jean-François Bonneville CHU de Liège-University of Liège, Liège, Belgium

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Albert Beckers CHU de Liège-University of Liège, Liège, Belgium

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: clinical profile and therapeutic responses . Endocrine-Related Cancer 22 353 – 367 . ( doi:10.1530/ERC-15-0038 ) Bevan JS 2005 Clinical review: the antitumoral effects of somatostatin analog therapy in acromegaly . Journal of Clinical

Article Type:
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DOI:
https://doi.org/10.1530/ERC-16-0356
Volume/Issue:
Volume 23: Issue 11
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E Baudin Endocrine Oncology Unit, Imaging Department, Gustave Roussy, Villejuif, France

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J Capdevila Medical Oncology Department, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), IOB Quirón-Teknon, Barcelona, Spain

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D Hörsch ENETS Center of Excellence, Zentralklinik Bad Berka GmbH, Bad Berka, Germany

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S Singh Division of Medical Oncology, University of Toronto, Sunnybrook Odette Cancer Center, Sunnybrook HSC, Toronto, Ontario, Canada

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M E Caplin Neuroendocrine Tumour Unit, Royal Free Hospital School of Medicine, London, UK

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E M Wolin Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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W Buikhuisen Department of Thorax Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands

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M Raderer Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria

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E Dansin Thoracic Oncology Unit, Centre Oscar Lambret, Lille, France

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C Grohe Department of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany

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D Ferone Neuroendocrine Tumour Unit, Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy

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A Houchard Data and Insights Generation and Strategy, Ipsen, Boulogne-Billancourt, France

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X-M Truong-Thanh Medical Affairs, Ipsen, Boulogne-Billancourt, France

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D Reidy-Lagunes Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical Center, New York, New York, USA

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the SPINET Study Group
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the SPINET Study Group

), leading to the development of somatostatin analogs (SSAs) as antisecretory and antiproliferative treatments across different NET primaries ( Del Olmo-Garcia et al. 2021 ). Two SSAs have been shown to significantly delay progression or death in metastatic

Article Type:
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DOI:
https://doi.org/10.1530/ERC-23-0337
Volume/Issue:
Volume 31: Issue 9
Open access
Marianne Pavel Department of Gastroenterology and Hepatology, Charité–Universitätsmedizin, Berlin, Germany

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David J Gross Neuroendocrine Tumor Unit, Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Marta Benavent Laboratorio de Oncología Molecular y Nuevas Terapias, Instituto de Biomedicina de Sevilla, Sevilla, Spain
Department of Endocrinology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK

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Petros Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK

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Raj Srirajaskanthan Neuroendocrine Tumour Unit, Institute of Liver Studies, Kings College Hospital, London, UK

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Richard R P Warner Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Matthew H Kulke Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Lowell B Anthony Division of Medical Oncology, University of Kentucky, Lexington, Kentucky, USA

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Pamela L Kunz Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA

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Dieter Hörsch Department of Gastroenterology/Endocrinology, Zentralklinik Bad Berka, Bad Berka, Germany

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Martin O Weickert The ARDEN NET Centre, ENETS Centre of Excellence, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Pablo Lapuerta Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

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Wenjun Jiang Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

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Kenneth Kassler-Taub Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

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Suman Wason Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

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Rosanna Fleming Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

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Douglas Fleming Ipsen Bioscience, Cambridge, Massachusetts, USA

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Rocio Garcia-Carbonero Oncology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), UCM, CNIO, CIBERONC, Madrid, Spain

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, National Cancer Institute 2015 , National Comprehensive Cancer Network 2017 ). Somatostatin analogs (SSAs), introduced in the mid-1980s for the management of CS, are considered the standard of care for patients suffering from this condition ( Boudreaux

Article Type:
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DOI:
https://doi.org/10.1530/ERC-17-0455
Volume/Issue:
Volume 25: Issue 3
Open access
Sara Pusceddu Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Antonio Facciorusso Gastroenterology Unit, Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy

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Luca Giacomelli Polistudium srl, Milan, Italy

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Natalie Prinzi Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Francesca Corti Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Monica Niger Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Massimo Milione Diagnostic Pathology and Laboratory Medicine Department, Fondazione IRCCS Istituto Nazionale dei Tumori, ENETS Center of Excellence, Milan, Italy

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Jorgelina Coppa Gastro-intestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, ENETS Center of Excellence, Milan, Italy

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Tommaso Cascella Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, ENETS Center of Excellence, Milan, Italy

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Iolanda Pulice Clinical Trial Center, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy

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Lavinia Biamonte Clinical Trial Center, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy

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Simonetta Papa Polistudium srl, Milan, Italy

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Maria Di Bartolomeo Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Aashni Shah Polistudium srl, Milan, Italy

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Rodolfo Sacco Gastroenterology Unit, Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy

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Filippo de Braud Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy
Oncology and Hemato-Oncology Department, Università degli Studi di Milano, Milan, Italy

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). Pharmacological treatment of GEP NETs comprises somatostatin analogs (SSAs; octreotide (OCT) long-acting release and lanreotide (LAN) autogel), chemotherapy, peptide receptor radiotherapy and targeted therapy with everolimus or sunitinib ( Oronsky et al. 2017

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0492
Volume/Issue:
Volume 28: Issue 7
Restricted access
Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Alessandra Dicitore Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Concetta Sciammarella Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Sergio Di Molfetta Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy

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Manila Rubino Unit of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, Milan, Italy

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Antongiulio Faggiano Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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represented by surgery followed by medical management, such as somatostatin analogs (SSAs), mTOR inhibitors, tyrosine kinase inhibitors, chemotherapy and peptide receptor radionuclide therapy. However, new treatment options to further improve survival outcomes

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0010
Volume/Issue:
Volume 25: Issue 6
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Shoucheng Ning Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Susan J Knox Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Griffith R Harsh Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Michael D Culler Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Laurence Katznelson Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN
Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Introduction Somatostatin is a peptide hormone that exerts its biologic activity, including inhibition of hormone secretion, by interacting with a family of G protein receptors. Administration of somatostatin analogs, such as lanreotide and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0003
Volume/Issue:
Volume 16: Issue 3
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Dik J Kwekkeboom Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Boen L Kam Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Martijn van Essen Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Jaap J M Teunissen Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Casper H J van Eijck Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Roelf Valkema Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Marion de Jong Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Wouter W de Herder Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Eric P Krenning Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Introduction Peptide receptor scintigraphy in man started with the in vivo demonstration of somatostatin receptor-positive tumors in patients using a radioiodinated somatostatin analog ( Krenning et al . 1989 ). Later, other radiolabeled

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DOI:
https://doi.org/10.1677/ERC-09-0078
Volume/Issue:
Volume 17: Issue 1
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E Ferrante
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C Pellegrini
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S Bondioni
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E Peverelli
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M Locatelli
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P Gelmini
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P Luciani
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A Peri
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G Mantovani
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S Bosari
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P Beck-Peccoz
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A Spada
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A Lania
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gene ( Luciani et al. 2005 ). The aim of this study was to identify the receptor subtype involved in the proapoptotic action of octreotide by evaluating the effect of superselective somatostatin analogs on caspase activity and apoptosis

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Research Article
DOI:
https://doi.org/10.1677/erc.1.01191
Volume/Issue:
Volume 13: Issue 3
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Amy Moreno Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology

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Argun Akcakanat Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology

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Mark F Munsell Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology

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Alpana Soni Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology

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James C Yao Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology

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Funda Meric-Bernstam Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology

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most carcinoid tumors highly express somatostatin receptors, treatment of gastrointestinal carcinoid tumors has largely involved somatostatin analogs or the combination of various chemotherapeutic agents. Although somatostatin analogs such as octreotide

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0202
Volume/Issue:
Volume 15: Issue 1
Free access