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Julie Refardt, Wouter T Zandee, Tessa Brabander, Richard A Feelders, Gaston J H Franssen, Leo J Hofland, Emanuel Christ, Wouter W de Herder, and Johannes Hofland

surface, with the somatostatin receptor subtype 2 (SST2) being expressed in up to 90% of gastroenteropancreatic NETs ( Reubi et al. 2010 , Gatto & Hofland 2011 ). According to this feature, SSTR-based imaging is the current standard for diagnosing and

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Mintallah Haider, Satya Das, Taymeyah Al-Toubah, Eleonora Pelle, Ghassan El-Haddad, and Jonathan Strosberg

delivery of targeted radiation to cancer cells by binding a radionuclide to a peptide molecule, which localizes to a specific protein expressed on the cell surface. In the instance of radiolabeled SSAs, the peptide is a somatostatin receptor agonist that

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Omar Abdel-Rahman, Angela Lamarca, Juan W Valle, and Richard A Hubner

endothelial growth factor (VEGF) pathway alterations ( Chen et al . 2014 ), as well as somatostatin receptor (SSTR)-related alterations. In this review, we provide an overview of the various considerations relating to SSTRs as potentially novel prognostic and

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Dik J Kwekkeboom, Boen L Kam, Martijn van Essen, Jaap J M Teunissen, Casper H J van Eijck, Roelf Valkema, Marion de Jong, Wouter W de Herder, and Eric P Krenning

Introduction Peptide receptor scintigraphy in man started with the in vivo demonstration of somatostatin receptor-positive tumors in patients using a radioiodinated somatostatin analog ( Krenning et al . 1989 ). Later, other radiolabeled

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Adriana Albani, Luis Gustavo Perez-Rivas, Sicheng Tang, Julia Simon, Kristin Elisabeth Lucia, Paula Colón-Bolea, Jochen Schopohl, Sigrun Roeber, Michael Buchfelder, Roman Rotermund, Jörg Flitsch, Jun Thorsteinsdottir, Jochen Herms, Günter Stalla, Martin Reincke, and Marily Theodoropoulou

patients with persistent or recurrent Cushing’s disease ( Pivonello et al. 2015 , Fleseriu et al. 2021 ). Pasireotide has a high affinity for the somatostatin receptor (SSTR) 5, which is abundantly expressed in corticotroph tumours and whose expression

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Martin K Bakht, Iulian Derecichei, Yinan Li, Rosa-Maria Ferraiuolo, Mark Dunning, So Won Oh, Abdulkadir Hussein, Hyewon Youn, Keith F Stringer, Chang Wook Jeong, Gi Jeong Cheon, Cheol Kwak, Keon Wook Kang, Alastair D Lamb, Yuzhuo Wang, Xuesen Dong, and Lisa A Porter

transdifferentiation of AdPC to NEPC under ARPI ( Li et al . 2017 ). The somatostatin receptor subtype 2 (SSTR-2) is prevalent in the majority NE tumors and DOTATOC and DOTATATE radioligands with affinity to SSTR are radiotracers for delineation of NE tumors ( Poeppel

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Chiara Borga, Carlo Alberto Dal Pozzo, Elisabetta Trevellin, Francesca Bergamo, Sabina Murgioni, Anna Caterina Milanetto, Claudio Pasquali, Umberto Cillo, Giada Munari, Chiara Martini, Eugenio De Carlo, Vittorina Zagonel, Vincenza Guzzardo, Gianmaria Pennelli, Angelo Paolo Dei Tos, Roberto Vettor, and Matteo Fassan

, intra-tumoral heterogeneity may affect both the definition of tumor grading ( Grillo et al. 2017 , Trikalinos et al. 2020 ) and imaging assessment of somatostatin receptors (SSTRs) expression, which are two important prognostic markers, particularly

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E Ferrante, C Pellegrini, S Bondioni, E Peverelli, M Locatelli, P Gelmini, P Luciani, A Peri, G Mantovani, S Bosari, P Beck-Peccoz, A Spada, and A Lania

scientific work. References Ballare E , Persani L, Lania AG, Filopanti M, Giammona E, Corbetta S, Mantovani S, Arosio M, Beck-Peccoz P, Faglia G et al. 2001 Mutation of somatostatin receptor type 5 in an acromegalic

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Cecile N Chougnet, Sophie Leboulleux, Caroline Caramella, Jean Lumbroso, Isabelle Borget, Désirée Déandreis, Pierre Duvillard, Dominique Elias, Thierry de Baere, Fritz-Line Vélayoudom-Céphise, Joël Guigay, Michel Ducreux, Martin Schlumberger, and Eric Baudin

Introduction Functional imaging has become critical for gastro–entero–pancreatic neuroendocrine neoplasm (GEP NEN) ( Krenning et al . 1994 , Baudin 2007 ). Somatostatin receptors (sst) are expressed by these tumors, and somatostatin receptor

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Sandra Valéria de Sá, Maria Lúcia Corrêa-Giannella, Márcio Carlos Machado, Jean Jorge S de Souza, Maria Adelaide Albergaria Pereira, Rosely Antunes Patzina, Sheila Aparecida Coelho Siqueira, Marcel Cerqueira César Machado, and Daniel Giannella-Neto

receptors 2 and 5 are the major somatostatin receptors in insulinomas: an in vivo and in vitro study. Journal of Clinical Endocrinology and Metabolism 88 5353 –5360. Bruno JF , Xu Y & Berelowitz M 1994 Somatostatin