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R A Stein
R A Stein
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
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D P McDonnell
D P McDonnell
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
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identify key obstacles and questions that must be resolved if ERRα is to be utilized as a therapeutic target in breast cancer. The estrogen receptor-signaling pathway In the absence of hormone, estrogen receptor (ER) resides in either
A Coopes
A Coopes
Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
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C E Henry
C E Henry
Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
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E Llamosas
E Llamosas
Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
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C E Ford
C E Ford
Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
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ovarian tumours resemble clear cell lesions of the endometrium, suggesting common therapeutic targets ( Fadare et al . 2013 , Levine & The Cancer Genome Atlas Research Network 2013 , Hoang et al . 2014 ). By contrast, while endometrioid endometrial
Goswin Y Meyer-Rochow
Goswin Y Meyer-Rochow
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Nicole E Jackson
Nicole E Jackson
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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John V Conaglen
John V Conaglen
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Denis E Whittle
Denis E Whittle
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Muthusamy Kunnimalaiyaan
Muthusamy Kunnimalaiyaan
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Herbert Chen
Herbert Chen
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Gunnar Westin
Gunnar Westin
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Johanna Sandgren
Johanna Sandgren
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Peter Stålberg
Peter Stålberg
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Elham Khanafshar
Elham Khanafshar
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Daniel Shibru
Daniel Shibru
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Quan-Yang Duh
Quan-Yang Duh
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Orlo H Clark
Orlo H Clark
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Electron Kebebew
Electron Kebebew
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Anthony J Gill
Anthony J Gill
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Rory Clifton-Bligh
Rory Clifton-Bligh
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Bruce G Robinson
Bruce G Robinson
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Diana E Benn
Diana E Benn
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Stan B Sidhu
Stan B Sidhu
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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chemotherapy or radiotherapy with a poor overall survival of 50% at 5 years ( Adler et al . 2008 ). The identification of reliable diagnostic and prognostic markers and the development of effective molecular therapeutic targets for the treatment of malignant
Miguel A Zaballos
Miguel A Zaballos
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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Adrián Acuña-Ruiz
Adrián Acuña-Ruiz
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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Marta Morante
Marta Morante
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander, Spain
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Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander, Spain
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Piero Crespo
Piero Crespo
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander, Spain
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Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Santander, Spain
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Pilar Santisteban
Pilar Santisteban
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain
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( Herrero et al. 2015 ). This illustrates how targeting a protein–protein interaction can yield therapeutic effects. The RAS/ERK pathway offers multiple potential therapeutic targets. We will next describe the main RAS GAPs and GEFs, the scaffold
Laura Gerard
Laura Gerard
Service de Gastroentérologie et d’Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Céline Patte
Céline Patte
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Laurence Chardon
Laurence Chardon
Service de Biochimie Biologie Moléculaire, Centre de Biologie Est, Hospices Civils de Lyon, Bron, France
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Valérie Hervieu
Valérie Hervieu
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
Service Central d’Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Service Central d’Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Léa Payen
Léa Payen
Institut de Cancérologie des Hospices Civils de Lyon, CIRculating CANcer Program (CIRCAN), Lyon, France
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Marion Allio
Marion Allio
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Claire Marx
Claire Marx
Service d'Endocrinologie-Diabète-Nutrition, Hospices Civils de Lyon, Hôpital Lyon Sud, Lyon, France
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Hugo Clermidy
Hugo Clermidy
Service de Chirurgie Thoracique, Vidéothoracoscopie et Transplantation Pulmonaire, Hospices Civils de Lyon, Hôpital Louis Pradel, Lyon, France
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Alice Durand
Alice Durand
Service de Gastroentérologie et d’Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Patrick Mehlen
Patrick Mehlen
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Julien Bollard
Julien Bollard
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Gilles Poncet
Gilles Poncet
Service de Chirurgie Digestive, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
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Colette Roche
Colette Roche
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Benjamin Gibert
Benjamin Gibert
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Thomas Walter
Thomas Walter
Service de Gastroentérologie et d’Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France
Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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Gastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France
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). NRP2 could thus represent a promising therapeutic target in NENs. An antibody directed against a part of the transmembrane domain (b1b2) of NRP2 has been developed and inhibits tumour growth and metastasis in pancreatic ductal adenocarcinoma via
Hung-Ming Lam
Hung-Ming Lam
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Bin Ouyang
Bin Ouyang
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Jing Chen
Jing Chen
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Jun Ying
Jun Ying
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Jiang Wang
Jiang Wang
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Chin-Lee Wu
Chin-Lee Wu
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Li Jia
Li Jia
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Mario Medvedovic
Mario Medvedovic
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Robert L Vessella
Robert L Vessella
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Shuk-Mei Ho
Shuk-Mei Ho
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
Department of Environmental Health, Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Medicine, Center for Environmental Genetics, Department of Urology, Cincinnati Veterans Affairs Medical Center, Cincinnati Cancer Center, University of Cincinnati Medical Center, Room 128 Kettering Complex, Cincinnati, Ohio 45267‐0056, USA
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PC We reasoned that GPR30 in CRPC metastases needs to be expressed at significant levels before we can consider it as a new therapeutic target for CRPC. Hence, we used IHC to assess the level of GPR30 expression in specimens obtained from two cohorts
G Capurso
G Capurso
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S Lattimore
S Lattimore
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T Crnogorac-Jurcevic
T Crnogorac-Jurcevic
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F Panzuto
F Panzuto
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M Milione
M Milione
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V Bhakta
V Bhakta
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N Campanini
N Campanini
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S M Swift
S M Swift
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C Bordi
C Bordi
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G Delle Fave
G Delle Fave
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N R Lemoine
N R Lemoine
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, and offers a potential novel therapeutic target for PETs. LCK is an src-like non-receptor protein tyrosine kinase, expressed mainly in T lymphocytes and thymocytes ( Anderson et al . 1994 ). LCK is also aberrantly expressed in different cancer types
Deborah J Marsh
Deborah J Marsh
Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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. Endocrine-Related Cancer 22 T35 – T54 . ( doi:10.1530/ERC-14-0516 ). Shen M Schmitt S Buac D Dou QP 2013 Targeting the ubiquitin-proteasome system for cancer therapy . Expert Opinion on Therapeutic Targets 17 1091 – 1108 . ( doi:10
Meenu Jain
Meenu Jain
Endocrine Oncology Branch, National Center for Advancing Translational Sciences, National Cancer Institute
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Lisa Zhang
Lisa Zhang
Endocrine Oncology Branch, National Center for Advancing Translational Sciences, National Cancer Institute
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Mei He
Mei He
Endocrine Oncology Branch, National Center for Advancing Translational Sciences, National Cancer Institute
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Ya-Qin Zhang
Ya-Qin Zhang
Endocrine Oncology Branch, National Center for Advancing Translational Sciences, National Cancer Institute
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Min Shen
Min Shen
Endocrine Oncology Branch, National Center for Advancing Translational Sciences, National Cancer Institute
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Electron Kebebew
Electron Kebebew
Endocrine Oncology Branch, National Center for Advancing Translational Sciences, National Cancer Institute
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Given that TOP2A was highly expressed in ACC samples, we evaluated its potential as a therapeutic target for ACC in vitro . Eleven of 14 TOP2A inhibitors had an antiproliferative effect in the NCI-H295R ACC cell line, five of the TOP2A inhibitors
Stephen Hiscox
Stephen Hiscox
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L Morgan
L Morgan
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Tim Green
Tim Green
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Robert I Nicholson
Robert I Nicholson
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et al. 2005 ). In this paper, we discuss the consequences of increased Src activity for the development of an aggressive, invasive cell phenotype and demonstrate its potential as a therapeutic target for anti-invasive therapies. Furthermore, our
