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Pedro Weslley Rosario, Gabriela Franco Mourão, Maurício Buzelin Nunes, Marcelo Saldanha Nunes, and Maria Regina Calsolari

Introduction Recently, it was proposed that some papillary thyroid carcinomas (PTC) will no longer be termed ‘cancer’ and instead be called ‘noninvasive follicular thyroid neoplasm with papillary-like nuclear features’ (NIFTP) ( Nikiforov et

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Pedro Weslley Rosario and Gabriela Franco Mourão

Definition Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an encapsulated or clearly delimited, noninvasive neoplasm with a follicular growth pattern and nuclear features of papillary thyroid carcinoma

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Ornella Affinito, Paolo Salerno, Alfonso D’Alessio, Mariella Cuomo, Ermanno Florio, Francesca Carlomagno, Agnese Proietti, Riccardo Giannini, Fulvio Basolo, Lorenzo Chiariotti, Sergio Cocozza, and Massimo Santoro

in DNA methylation pattern in thyroid neoplasms. The TCGA (Cancer Genome Atlas) study reported the methylation profile of a large cohort of PTC cases and identified four distinct tumor clusters termed ‘classical 1’ and ‘classical 2’ (mainly featuring

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Isabel Amendoeira, Tiago Maia, and Manuel Sobrinho-Simões

types of ‘UMPs’ (‘Follicular tumour of Uncertain Malignant Potential’ and ‘Well differentiated tumour of Uncertain Malignant Potential’), the newly created NIFTP (Non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is

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Xiulong Xu, Helen Ding, Geetha Rao, Shalini Arora, Constantine P Saclarides, Joseph Esparaz, Paolo Gattuso, Carmen C Solorzano, and Richard A Prinz

SHH pathway is activated in thyroid neoplasms and can contribute to increased cell proliferation. Materials and methods Tumor specimens and patient information Paraffin-embedded tumor blocks from patients with thyroid neoplasms were retrieved from the

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Jonathan M Fussey, Robin N Beaumont, Andrew R Wood, Bijay Vaidya, Joel Smith, and Jessica Tyrrell

:// ) Ichikawa Y Saito E Abe Y Homma M Muraki T 1976 Presence of TSH receptor in thyroid neoplasms . Journal of Clinical Endocrinology and Metabolism 42 395 – 398 . (

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Joseph M Shulan, Leonid Vydro, Arthur B Schneider, and Dan V Mihailescu

of TSH receptor in thyroid neoplasms . Journal of Clinical Endocrinology and Metabolism 42 395 – 398 . ( ) 10.1210/jcem-42-2-395 Kim KW Park YJ Kim EH Park SY Park do J Ahn SH Park do J Jang HC Cho BY

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E Saggiorato, R De Pompa, M Volante, S Cappia, F Arecco, A P Dei Tos, F Orlandi, and M Papotti

, Akahani S, Yoshida J, Hattori K, Okamoto S, Sawada T, Raz A & Kubo T 1999 Expression of galectin-3 in fine-needle aspirates as a diagnostic marker differentiating benign from malignant thyroid neoplasms. Cancer 85 2475 –2484

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Pablo Valderrabano, Laila Khazai, Marino E Leon, Zachary J Thompson, Zhenjun Ma, Christine H Chung, Julie E Hallanger-Johnson, Kristen J Otto, Kara D Rogers, Barbara A Centeno, and Bryan McIver

been proposed to reclassify the encapsulated, non-invasive, follicular variant papillary thyroid carcinoma (FVPTC) as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) ( Nikiforov et al. 2016 ). This change in the

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Theodoros Foukakis, Arief Gusnanto, Amy YM Au, Anders Höög, Weng-Onn Lui, Catharina Larsson, Göran Wallin, and Jan Zedenius

. A classification model of five genes is specific for high-risk FTCs (model 1) Since the majority of follicular thyroid neoplasms have an indolent course, we first investigated whether the high-risk tumors can be genetically predicted