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Amruta Ashtekar, Danielle Huk, Alexa Magner, Krista La Perle, Xiaoli Zhang, José I Piruat, José López-Barneo, Sissy M Jhiang and Lawrence S Kirschner

to overcome the hypoxic conditions in tumors, but newer data suggest that metabolic dysfunction is itself a driver of tumorigenesis. Mechanisms that have been proposed to explain how loss of SDHD leads to thyroid tumorigenesis include (1) an increase

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Caterina Tiozzo, Soula Danopoulos, Maria Lavarreda-Pearce, Sheryl Baptista, Radka Varimezova, Denise Al Alam, David Warburton, Virender Rehan, Stijn De Langhe, Antonio Di Cristofano, Saverio Bellusci and Parviz Minoo

through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocrine-Related Cancer 19 111–122 (doi:10.1530/ERC-10-0327).

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Caterina Tiozzo, Soula Danopoulos, Maria Lavarreda-Pearce, Sheryl Baptista, Radka Varimezova, Denise Al Alam, David Warburton, Rehan Virender, Stijn De Langhe, Antonio Di Cristofano, Saverio Bellusci and Parviz Minoo

ultrasound to nodular hyperplasia (also called goiter) and neoplastic transformation ( Ezzat et al . 1994 , Rivas & Santisteban 2003 ). Recently, information on the molecular events controlling thyroid tumorigenesis has grown considerably. However, the

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Xiaoli Liu, Justin Bishop, Yuan Shan, Sara Pai, Dingxie Liu, Avaniyapuram Kannan Murugan, Hui Sun, Adel K El-Naggar and Mingzhao Xing

thyroid tumorigenesis ( Xing 2013 ). In the present study, we examined TERT promoter mutations in various thyroid tumors to explore novel genetic alterations in thyroid tumorigenesis. Subjects and methods Thyroid tumor tissues, cell lines, and DNA

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De-tao Yin, Wenxun Wu, Mingchuang Li, Qi-en Wang, Hongqiang Li, Yongfei Wang, Yifeng Tang and Mingzhao Xing

important role in thyroid tumorigenesis and progression and that DKK3 is a major thyroid TSG. As such the hypermethylation of DKK3 may have a prognostic value in the risk stratification of PTC. In summary, our results suggest that DKK3 is a potential

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Mingzhao Xing

diabetes mellitus, atherosclerosis, hypertension, inflammatory diseases, neurodegenerative disorders, and other diseases ( Valko et al . 2007 , Durackova 2010 ). Possible mechanisms of OS and ROS in thyroid tumorigenesis As with thyroid cancer, OS has

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M Xing

each of the three genetic alterations alone is sufficient to cause thyroid tumorigenesis. The mutual exclusivity among these common genetic alterations in thyroid tumor may not be surprising, though, as the signaling pathways of these activating genetic

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Flavia R M Latini, Jefferson P Hemerly, Gisele Oler, Gregory J Riggins and Janete M Cerutti

. 2006 ). In the present study, we sought to determine whether the loss of ABI3BP expression plays a role in thyroid tumorigenesis. We expanded our analysis and investigated the expression of ABI3BP in a larger series of thyroid tumors, which includes

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Jesús Morillo-Bernal, Lara P Fernández and Pilar Santisteban

/genotype. Analysis of migration in thyroid cancer cell lines In an attempt to discern the role of FOXE1 in thyroid tumorigenesis, and considering that this gene is involved in the migration of thyroid cells from the pharyngeal floor to the trachea during

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Natassia E Bufalo, Janaina L Leite, Ana C T Guilhen, Elaine C Morari, Fabiana Granja, Ligia V M Assumpcao and Laura S Ward

knowledge, this is the first report on CYP1A1 influence on thyroid tumorigenesis. Interestingly, we found CYP1A1 wild-type allele to be more frequent both in thyroid nodules and in papillary carcinomas than in the control population, suggesting that